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Gut bacterial translocation is associated with microinflammation in end‐stage renal disease patients
Abstract
Aim: To investigate whether gut bacteria translocation occurs in end‐stage renal disease patients and contributes to microinflammation in end‐stage renal disease (ESRD). Methods: The subjects were divided into two groups: nondialysed ESRD patients (n = 30) and healthy controls (n = 10). Blood samples from all participants were subjected to bacterial 16S ribosomal DNA amplification and DNA pyrosequencing to determine the presence of bacteria, and the alteration of gut microbiomes were examined with the same methods. High‐sensitive C‐reactive protein and interleukin‐6 were detected. Plasma D‐lactate was tested for gut permeability. Results: Bacterial DNAs were detected in the blood of 20% (6/30) of the ESRD patients. All the observed genera in blood (Klebsiella spp, Proteus spp, Escherichia spp, Enterobacter spp, and Pseudomonas spp) were overgrown in the guts of the ESRD patients. Plasma D‐lactate, High‐sensitive C‐reactive protein, and interleukin‐6 levels were significantly higher in patients with bacterial DNA than those without. The control group showed the same results as that of patients without bacterial DNA. Conclusion: Bacterial translocation occurs in ESRD patients and is associated with microinflammation in end stage renal disease.
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“In contrast to Lactobacillus, the population of Enterobacteriaceae of the Proteobacteria phylum is expanded in CKD101,105.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [105]
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Cites
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 19,549
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Inflammation enhances cardiovascular risk and mortality in hemodialysis patients
Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T., & Wanner, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00273.x · Cited by 1,531
Bacterial translocation (BT) in cirrhosis†
Wiest, R., & Garcia‐Tsao, G. (2005) · Hepatology · doi:10.1002/hep.20632 · Cited by 677
The Macaque Gut Microbiome in Health, Lentiviral Infection, and Chronic Enterocolitis
McKenna, P. M., Hoffmann, C., Minkah, N. K., Aye, P. P., Lackner, A. A., Liu, Z. Z., Lozupone, C., Hamady, M., Knight, R. D., & Bushman, F. D. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040020 · Cited by 445
Macfie, J., OBoyle, C., Mitchell, C. J., Buckley, P. M., Johnstone, D. J., & Sudworth, P. (1999) · Gut · doi:10.1136/gut.45.2.223 · Cited by 414
Steffen, E. K., Berg, R. D., & Deitch, E. A. (1988) · Journal of Infectious Diseases · doi:10.1093/infdis/157.5.1032 · Cited by 234
Serum D(−)-lactate levels as an aid to diagnosing acute intestinal ischemia
Murray, M. J., Gonze, M. D., Nowak, L. R., & Cobb, C. F. (1994) · The American Journal of Surgery · doi:10.1016/0002-9610(94)90101-5 · Cited by 224
Bacterial translocation in the gut
Wiest, R., & Rath, H. C. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00024-6 · Cited by 206
Apoptosis as a proinflammatory event: What can we learn from bacteria-induced cell death?
Zychlinsky, A., & Sansonetti, P. J. (1997) · Trends in Microbiology · doi:10.1016/s0966-842x(97)01044-5 · Cited by 184
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BackgroundFeng, Y., Cao, G., Chen, D., Vaziri, N. D., Chen, L., Zhang, J., Wang, M., Guo, Y. P., & Zhao, Y. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03155-9 · Cited by 201
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Self-citationMishima, E., Fukuda, S., Shima, H., Hirayama, A., Akiyama, Y., Takeuchi, Y., Fukuda, N. N., Suzuki, T., Suzuki, C., Yuri, A., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014060530 · Cited by 193
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Felizardo, R. J. F., Watanabe, I. K. M., Dardi, P., Rossoni, L. V., & Câmara, N. O. S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.019 · Cited by 181
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Shi, K., Wang, F., Jiang, H., Liu, H., Wei, M., Wang, Z., & Xie, L. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3202-7 · Cited by 165
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“Bacterial translocation occurs in ESRD patients and was associated with microinflammation (Wang et al. 2012), which was more severe in hemodialysis patients (Shi et al. 2014).”
BackgroundImpact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression
Castillo-Rodríguez, E., Fernández-Prado, R., Esteras, R., Pérez-Gómez, M. V., Gracia-Iguacel, C., Fernández‐Fernández, B., Kanbay, M., Tejedor, A., Lázaro, A., Ruiz‐Ortega, M., et al. (2018) · Toxins · doi:10.3390/toxins10070300 · Cited by 154
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Iorio, B. R. D., Rocchetti, M. T., Angelis, M. D., Cosola, C., Marzocco, S., Micco, L. D., di Bari, I., Accetturo, M., Vacca, M., Gobbetti, M., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091424 · Cited by 145
Zhao, J., Ning, X., Liu, B., Dong, R., Bai, M., & Sun, S. (2021) · Renal Failure · doi:10.1080/0886022x.2020.1864404 · Cited by 150
“Study Year Region Center number Disease/severity n (case) n (control) Hemodialysis Peritoneal dialysis Kidney transplant No dialysis Wang et al. 2012 Shaanxi, China 1 ESRD 30 10 0 0 0 30 Wang et al. 2012 Taiwan, China 1 ESRD 29 41 0 29 0 0 Vaziri et al. 2013 California, USA 1 ESRD 24 12 24 0 0 0…”
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Sampaio‐Maia, B., Simões‐Silva, L., Pestana, M., Araújo, R., & Soares‐Silva, I. (2016) · Advances in applied microbiology · doi:10.1016/bs.aambs.2016.06.002 · Cited by 120
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BackgroundInflammation and Peritoneal Dialysis
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The Chronic Kidney Disease—Colonic Axis
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BackgroundResultCosola, C., Rocchetti, M. T., di Bari, I., Acquaviva, P. M., Maranzano, V., Corciulo, S., Ciaula, A. D., Palo, D. M. D., la Forgia, F. M., Fontana, S., et al. (2021) · Toxins · doi:10.3390/toxins13050334 · Cited by 72
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“Aberrations in blood microbiota have been identified in several diseases, including Parkinson’s disease (13), renal disease (25), cardiovascular disease (15), and liver fibrosis (26).”
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“(47) Five species were overgrown: Klebsiella spp.”
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“Keywords: fecal microbiota transplantation, gut microbiota, BAFF, IgA nephropathy, mouse model INTRODUCTION IgA nephropathy (IgAN) is the most common primary glomerulonephritis throughout most developed countries of the world (1) and it shows a progression to end-stage renal disease (ESRD) in approximately 15 to 25 pe…”
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InfluentialWang, H., Huang, B., Wang, W., Li, J., Chen, Y., Flynn, T., Zhao, M., Zhou, Z., Lin, X., Zhang, Y., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.049 · Cited by 67
Metabolic Abnormalities in Diabetes and Kidney Disease: Role of Uremic Toxins
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Intestinal Microbiota-Kidney Cross Talk in Acute Kidney Injury and Chronic Kidney Disease
Noel, S., Martina-Lingua, M. N., Bandapalle, S., Pluznick, J. L., Hamad, A. R. A., Peterson, D. A., & Rabb, H. (2014) · Nephron Clinical Practice · doi:10.1159/000363209 · Cited by 59
Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet
Moraes, C., Fouque, D. P., Amaral, A. C. F., & Mafra, D. (2015) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2015.06.004 · Cited by 57
Snelson, M., Clarke, R., Nguyen, T. V., Penfold, S. A., Forbes, J. M., Tan, S. M., & Coughlan, M. T. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000851 · Cited by 58
Microbiome modulation as a novel therapeutic approach in chronic kidney disease
Sumida, K., Lau, W. L., Kovesdy, C. P., Kalantar‐Zadeh, K., & Kalantar‐Zadeh, K. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000661 · Cited by 57
“Other groups have reported that the number of Enterobacteriaceae (especially Enterobacter, Klebsiella, and Escherichia), Enterococci and Clostridium perfringens were significantly higher in patients with ESRD than in healthy controls [23,24].”
BackgroundGut Microbiome and Organ Fibrosis
Costa, C. F. F. A., Sampaio‐Maia, B., Araújo, R., Nascimento, D. S., Ferreira‐Gomes, J., Pestana, M., Azevedo, M. J., & Alencastre, I. S. (2022) · Nutrients · doi:10.3390/nu14020352 · Cited by 53
Ćirović, A., Đenić, A., Clarke, B. L., Vassallo, R., Ćirović, A., & Landry, G. M. (2022) · Toxicology · doi:10.1016/j.tox.2022.153355 · Cited by 52
Winther, S. A., Henriksen, P., Vogt, J. K., Hansen, T. H., Ahonen, L. L., Suvitaival, T., Zobel, E. H., Frimodt‐Møller, M., Hansen, T. W., Hansen, T. F., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05260-y · Cited by 51
The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue
Lucas, K., Morris, G., Anderson, G., & Maes, M. H. J. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150317224645 · Cited by 50
Lee, T. H., Chen, J., Wu, C., Lin, T., Hung, S., & Yang, H. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100638 · Cited by 52
“In 2012, Wang and colleagues reported that all the observed genera, including Klebsiella spp, Proteus spp, Escherichia spp, Enterobacter spp, and Pseudomonas spp, were overgrown in the guts of ESKD patients, and bacterial DNAs can be detected in the blood of 20% of ESKD patients [51].”
BackgroundInfluentialMarch, D. S., Jones, A. W., Thatcher, R., & Davison, G. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1670-9 · Cited by 57
Inflammasome Fuels Dengue Severity
Shrivastava, G., Leon, P. C. V., & Calvo, E. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00489 · Cited by 46
“, 2012) and even end stage kidney disease (Wang et al., 2012).”
BackgroundStanford, J., Charlton, K. E., Stefoska‐Needham, A., Zheng, H., Bird, L., Borst, A., Fuller, A., & Lambert, K. (2020) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2020.07.008 · Cited by 48
Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity
Rychter, A. M., Ratajczak, A. E., Zawada, A. E., Dobrowolska, A., & Krela‐Kaźmierczak, I. (2020) · Nutrients · doi:10.3390/nu12030814 · Cited by 46
“This is directly related to the translocation of endotoxins, microbial components and microbial metabolites such as lipopolysaccharides (LPS) into the systemic circulation [141,142].”
BackgroundExploring blood microbial communities and their influence on human cardiovascular disease
Khan, I., Khan, I., Jianye, Z., Xiao-hua, Z., Khan, M., Hilal, M. G., Kakakhel, M. A., Mehmood, A., An, L., & Zhiqiang, L. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24354 · Cited by 39
Acute haemodynamic changes during haemodialysis do not exacerbate gut hyperpermeability
Wong, J., Lenaerts, K., Meesters, D. M., Damink, S. W. M. O., van Eijk, H. M. H., Vilar, E., & Farrington, K. (2019) · Bioscience Reports · doi:10.1042/bsr20181704 · Cited by 38
Lim, P., Wang, H. F., Lee, M. C., Chiu, L.-S., Wu, M.-Y., Chang, W.-C., & Wu, T. K. (2020) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2020.07.002 · Cited by 38
New Insights into Molecular Mechanisms of Chronic Kidney Disease
Frąk, W., Kućmierz, J., Szlagor, M., Młynarska, E., Rysz, J., & Franczyk, B. (2022) · Biomedicines · doi:10.3390/biomedicines10112846 · Cited by 42
“[88] have shown excessive colonization of the Klebsiella spp.”
BackgroundYong, Y. K., Tan, H. Y., Soe, H. J., Shankar, E. M., Natkunam, S. K., Sathar, J., Manikam, R., & Sekaran, S. D. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1226-4 · Cited by 37
“Although MT has been studied extensively in HIV disease [40], it’s also shown to play an important role in other diseases such as graft versus host disease after hematopoietic stem cell transplantation [41], inflammatory bowel syndrome [42], chronic liver disease [43] and even end stage of kidney disease [44].”
Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury
Lin, Y.-H., Platt, M. P., Fu, H., Gui, Y., Wang, Y., González-Juarbe, N., Zhou, D. F., & Yu, Y. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra120.002235 · Cited by 38
Endotoxemia in End‐Stage Kidney Disease
Wong, J., Vilar, E., & Farrington, K. (2014) · Seminars in Dialysis · doi:10.1111/sdi.12280 · Cited by 35
“Other circulating bacterial products such as bacterial DNA fragments have also been associated with inflammation (4,9,26).”
BackgroundIncreased Hepato-Splanchnic Vasoconstriction in Diabetics during Regular Hemodialysis
Ribitsch, W., Schneditz, D., Franssen, C. F. M., Schilcher, G., Stadlbauer, V., Horina, J. H., & Rosenkranz, A. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145411 · Cited by 35
“As a consequence, bacterial translocation, endotoxemia, and systemic inflammation might develop as a result of an ischemic gut barrier during HD [5] [6] [26].”
Backgroundγδ T‐cell responses during HIV infection and antiretroviral therapy
Juno, J. A., & Eriksson, E. M. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1069 · Cited by 34
Carron, C., de Barros, J.-P. P., Gaiffe, É., Deckert, V., Adda-Rezig, H., Roubiou, C., Laheurte, C., Masson, D., Simula‐Faivre, D., Louvat, P., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01630 · Cited by 35
“Until now, GBT has been assessed by the identification of the same bacterial species in the intestine microbiota and in the peripheral blood of ESRD patients (23).”
BackgroundXie, J., Ma, X., Zheng, Y., Mao, N., Ren, S., & Fan, J. (2022) · Renal Failure · doi:10.1080/0886022x.2022.2143378 · Cited by 35
The Role of Gut Microbiota in High-Fat-Diet-Induced Diabetes: Lessons from Animal Models and Humans
Qi, Y., & Wang, X. (2023) · Nutrients · doi:10.3390/nu15040922 · Cited by 37
Significance of the Gut Microbiota in Acute Kidney Injury
Kobayashi, T., Iwata, Y., Nakade, Y., & Wada, T. (2021) · Toxins · doi:10.3390/toxins13060369 · Cited by 32
“Interestingly, in patients with ESRD, DNA from gut bacteria was detected in the blood in addition to increased blood levels of D-lactate, high-sensitivity C-reactive protein, and IL-6 [51].”
BackgroundMeasurement of the intestinal permeability in chronic kidney disease
Terpstra, M. L., Singh, R., Geerlings, S. E., & Bemelman, F. J. (2016) · World Journal of Nephrology · doi:10.5527/wjn.v5.i4.378 · Cited by 32
“…, 2014 [plasma endotoxin] 0.95 0.12 22 0.17 0.1 10 6.65 [4.75, 8.54] Szeto et al , 2008 [plasma LPS] 0.44 0.18 30 0.013 0.007 10 2.66 [1.72, 3.60] Wang et al , 2012 [D-lactate] 7.272 2.16 30 4.82 0.93 10 1.24 [0.47, 2.01] -20 -10 0 10 20 Decreased permeability Increased permeability Figure 3…”
InfluentialFicek, J., Wyskida, K., Ficek, R., Wajda, J., Klein, D., Witkowicz, J., Rotkegel, S., Spiechowicz, U., Kocemba-Dyczek, J., Ciepał, J., et al. (2017) · International Urology and Nephrology · doi:10.1007/s11255-016-1495-5 · Cited by 32
Gut microbiota disturbances and protein-energy wasting in chronic kidney disease: a narrative review
Martín-del-Campo, F., Avesani, C. M., Stenvinkel, P., Lindholm, B., Cueto-Manzano, A. M., & Cortés–Sanabria, L. (2023) · Journal of Nephrology · doi:10.1007/s40620-022-01560-1 · Cited by 31
“Bacterial translocation is recognized as a cause of local and systemic inflammation [28].”
BackgroundGut Microbiota-Targeted Interventions in the Management of Chronic Kidney Disease
Sumida, K., Pierre, J. F., yuzefpolskaya, M., Colombo, P. C., Demmer, R. T., & Kovesdy, C. P. (2023) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2023.151408 · Cited by 31
March, D. S., Graham-Brown, M. P. M., Stover, C. M., BISHOP, N. C., & Burton, J. O. (2017) · BioMed Research International · doi:10.1155/2017/5765417 · Cited by 31
“More recent investigations have employed gut bacterial DNA fragments as a method to assess intestinal disturbances in HD patients [10, 93, 111].”
BackgroundFukui, H. (2016) · Cellular & Molecular Medicine Open access · doi:10.21767/2573-5365.100023 · Cited by 30
“Plasma Dlactate was high in patients with end-stage renal disease and positive blood bacterial DNA [38].”
Background
Metadata
- Authors
- WANG, F., JIANG, H., SHI, K., REN, Y., ZHANG, P., & CHENG, S.
- Affiliations
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
- Corresponding author
- JIANG, HONGLI
- Venue
- Nephrology
- Publisher
- Wiley
- Published
- 2012-10-29
- Volume
- 17
- Issue
- 8
- Pages
- 733-738
- ISSN
- 1320-5358 (ISSN-L)
- 1440-1797
- OpenAlex
- W2140999961
- Cited by
- 209
- References
- 32
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 17 · 2023: 18 · 2022: 19 · 2021: 22 · 2020: 24 · 2019: 23 · 2018: 16 · 2017: 13 · 2016: 17 · 2015: 14 · 2014: 9 · 2013: 4
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- gut bacterial translocation, end-stage renal disease, microinflammation, gut microbiota, D-lactate, intestinal permeability, C-reactive protein, interleukin-6, Klebsiella, Proteus, Escherichia, Enterobacter, Pseudomonas, dialysis patients
- MeSH terms
- Adult, Aged, Bacteria, C-Reactive Protein, Feces, Female, Humans, Inflammation, Kidney Failure, Chronic, Male, Middle Aged, RNA, Ribosomal, 16S, Biomarkers, Interleukin-6, Up-Regulation, Chi-Square Distribution, Case-Control Studies, Sequence Analysis, DNA, Inflammation Mediators, Bacterial Translocation, Lactic Acid, Ribotyping, Gastrointestinal Tract, Metagenome
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