Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity
Open accessAbstract
AIM: The aim of the present study was to investigate the effects of acute paroxetine administration on brain activity related to motivation. METHODS: Sixteen healthy subjects participated in a randomized, single-blind, no-drug/placebo-controlled, cross-over study. After administration of no drug, placebo or paroxetine (selective serotonin reuptake inhibitor; 20 mg), subjects underwent functional magnetic resonance imaging while performing a monetary incentive delay task. We analyzed the differences in brain activities of the reward anticipation/motor preparation period that are subject to motivational modulation. For this purpose, we subdivided the incentive trials on the basis of whether the reaction times (RT) were slower or faster than the subject's mean RT (slow RT and fast RT trials). RESULTS: No drug and placebo showed robust activation differences in the globus pallidus and putamen for the fast RT trials compared to the slow RT trials, whereas paroxetine showed none. Paroxetine showed significantly lower activations in the globus pallidus, insula, putamen and dorsolateral prefrontal cortex compared to no drug in the fast RT trials. CONCLUSIONS: Paroxetine single acute administration diminished brain activity induced by motivation in healthy subjects. This may partially explain the increased lack of motivation seen in patients with relatively mild symptoms after taking a dose of paroxetine for the first time.
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Some evidence suggests an involvement of serotonin in reward anticipation.
“Although the serotonergic system has been mainly associated with consummatory pleasure, some evidence suggests an involvement of serotonin in reward anticipation (Marutani et al., 2011).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Marutani et al., 2011
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- Authors
- Marutani, T., Yahata, N., Ikeda, Y., Ito, T., Yamamoto, M., Matsuura, M., Matsushima, E., Okubo, Y., Suzuki, H., & Matsuda, T.
- Affiliations
- Tokyo Medical and Dental University (JP)
- The University of Tokyo (JP)
- Nippon Medical School (JP)
- Brain Science Institute, Tamagawa University (JP)
- Corresponding author
- Matsuda, Tetsuya
- ORCID
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2011-03
- Volume
- 65
- Issue
- 2
- Pages
- 191-198
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1550516012
- Cited by
- 16
- References
- 33
- Citations by year
- 2024: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 4 · 2013: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (20591378, 22791143, 21791151)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- paroxetine, acute drug administration, motivation, reward anticipation, monetary incentive delay task, globus pallidus, putamen, insula, dorsolateral prefrontal cortex, reaction time, selective serotonin reuptake inhibitors, lack of motivation
- MeSH terms
- Adult, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Motivation, Psychomotor Performance, Reaction Time, Paroxetine
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