Systemic expression of a newly recognized protein, LECT2, in the human body
Abstract
LECT2 (leukocyte cell-derived chemotaxin 2) is a new, recently isolated protein shown to be synthesized by hepatocytes. All hepatocytes show diffuse immunostaining for LECT2 within the cytoplasm. In the present study an attempt was made to investigate the expression of LECT2 in normal and diseased human organs and tissues, other than the liver, using indirect immunoperoxidase staining. LECT2 was found to be generally expressed in vascular, endothelial and smooth muscle cells, adipocytes, cerebral nerve cells, apical squamous epithelia, parathyroid cells, sweat and sebaceous glandular epithelia, Hassall bodies and some mononuclear cells in immunohematopoietic tissue, although some of these cells and tissues were occasionally unstained in diseased conditions. Alternatively, this protein was generally negative, although it was occasionally positively stained in osteoblasts, chondrocytes, cardiac and skeletal muscle cells, smooth muscle cells of the gastrointestinal tract, and the epithelial cells of some tissues. LECT2 seems to be related to the cell cycle or repair process following damage to a variety of cells.
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Tissues normally lacking LECT2 exhibit increased expression of LECT2 in disease settings, indicating improper upregulation of LECT2 may contribute to pathological conditions.
“Interestingly, tissues normally lacking LECT2 exhibit increased expression of LECT2 in disease settings, indicating that improper upregulation of LECT2 may contribute to pathological conditions [246,247].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [247]
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Hepatokines and metabolism: Deciphering communication from the liver
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Leukocyte cell-derived chemotaxin-2: it's role in pathophysiology and future in clinical medicine
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- Authors
- Nagal, H., Hamada, T., Uchida, T., Yamagoe, S., & Suzuki, K.
- Affiliations
- Nihon University (JP)
- National Institute of Infectious Diseases (JP)
- Corresponding author
- Uchida, Toshikazu
- ORCID
- Suzuki, Kazuo
- Venue
- Pathology International
- Publisher
- Wiley
- Published
- 1998-11
- Volume
- 48
- Issue
- 11
- Pages
- 882-886
- ISSN
- 1320-5463 (ISSN-L)
- 1440-1827
- OpenAlex
- W2157464785
- Cited by
- 50
- References
- 8
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 2
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pathology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- LECT2, protein expression, tissue distribution, hepatocytes, endothelial cells, smooth muscle cells, adipocytes, cell cycle, tissue repair, chemokines
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Chemotactic Factors, Child, Child, Preschool, Female, Humans, Immunoenzyme Techniques, Infant, Male, Neoplasms, Organ Specificity, Tissue Distribution, Protein Biosynthesis, Intercellular Signaling Peptides and Proteins
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