Leukocyte cell-derived chemotaxin-2: it's role in pathophysiology and future in clinical medicine
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INTRODUCTIONLeukocyte cell-derived chemotaxin-2 (LECT2) is a highly conserved protein with roles in cell development, sepsis, liver disease, metabolic syndrome, arthritis, cancer, and amyloidosis, among others.We will review its genetics, structure, role in physiology, and its future as a biomarker and therapeutic target across many diseases.Studies involving LECT2 were identified using PubMed and compiled into a single review paper.Research on LECT2 suggests a future as a biomarker of disease and potential therapeutic target. BACKGROUNDThe discovery of leukocyte cell-derived chemotaxin-2 (LECT2) was the result of a drive to find novel biomarkers of inflammatory diseases.1 It was first isolated in humans by Yamagoe et al. 1 from phytohemagglutinin-stimulated T-cell leukemia SKW-3 cells and identified as a chemotaxin of neutrophils.Chemotaxins are substances released by cells that stimulate the movement of white blood cells and LECT2 derived its name from this in vitro chemotactic ability at its initial discovery.1 However, it is now known to have several other functions in the human body and it is no longer limited to chemotaxis.There has been a rapid expansion of knowledge regarding its function with major developments in liver regeneration, 2-8 immune modulation, 1,9-15 bone growth, 9,[16][17][18][19][20] neuronal development, 21 glucose metabolism and metabolic syndrome, 10,22-27 cancer, 9,28-33 and amyloidosis, [34][35][36][37][38][39] among others.It is often found secreted in the bloodstream and expression of this protein has been identified in liver cells, neurons, various epithelial cells, parathyroid cells, and white blood cells, although it is felt to be most often secreted by the liver. 40However, despite the multifunctional role of LECT2 in several different organ systems, there has yet to be a comprehensive review that summarizes all of the current knowledge and information.We will attempt to synthesize current reported literature on this increasingly important protein and explore its potential future in modern clinical medicine in relation to disease pathophysiology (Table 1) 6,13,17,18,22,28,29,33,41,42 and as a biomarker (Table 2).2,3,6,[9][10][11][12][13][14][15][16][17][18][19][22][23][24][28][29][30][31][33][34][35][36][37][38][39][40][41][42]
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Tissues normally lacking LECT2 exhibit increased expression of LECT2 in disease settings, indicating improper upregulation of LECT2 may contribute to pathological conditions.
“Interestingly, tissues normally lacking LECT2 exhibit increased expression of LECT2 in disease settings, indicating that improper upregulation of LECT2 may contribute to pathological conditions [246,247].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [246]
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- Authors
- Slowik, V, & Apte, U.
- Affiliations
- Children's Mercy Hospital (US)
- University of Kansas Medical Center (US)
- Corresponding author
- Slowik, V
- Venue
- Clinical and Translational Science
- Publisher
- Wiley
- Published
- 2017-05-23
- Volume
- 10
- Issue
- 4
- Pages
- 249-259
- ISSN
- 1752-8054 (ISSN-L)
- 1752-8062
- PMC
- PMC5504477
- OpenAlex
- W2610218880
- Cited by
- 44
- References
- 54
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 4
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical and Translational Science (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- LECT2, biomarkers, therapeutic target, liver regeneration, sepsis, metabolic syndrome, cancer, amyloidosis, immunomodulation, bone growth, glucose metabolism, neutrophil chemotaxis, liver disease, inflammation, disease pathophysiology, clinical translation
- MeSH terms
- Amyloidosis, Animals, Cell Cycle, Disease Models, Animal, Humans, Immune System, Leukocytes, Liver Regeneration, Neoplasms, Osteoarthritis, Biomarkers, Sepsis, Metabolic Syndrome, Intercellular Signaling Peptides and Proteins, Mice
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