The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Emmprin (basigin/CD147): Matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression
Abstract
Emmprin (basigin, CD147) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily. It is highly expressed on the surface of tumor cells and stimulates adjacent fibroblasts or tumor cells to produce matrix metalloproteinases. Moreover, it has recently been shown that emmprin also stimulates expression of vascular endothelial growth factor and hyaluronan, which leads to angiogenesis and anchorage‐independent growth/multidrug resistance, respectively. These findings have made emmprin an important molecule in tumor progression and, thus, more attractive as a target for antitumor treatment. However, other functions of emmprin, including as an activator of T cells, a chaperone for monocarboxylate transporters, a receptor for cyclophilin A and a neural recognition molecule, are also being identified in physiological and pathological conditions. Therefore, it is essential to develop specific means to control particular functions of emmprin, for which elucidation of each mechanism is crucial. This review will discuss the role of emmprin in tumor progression and recent advances in the molecular mechanisms of diverse phenomena regulated by emmprin.
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Cites
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Active Site Residues of Cyclophilin A Are Crucial for Its Signaling Activity via CD147
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Cited by
Role of monocarboxylate transporters in human cancers: state of the art
Pinheiro, C., Longatto-Filho, A., Azevedo-Silva, J., Casal, M., Schmitt, F. C., & Baltazar, F. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9428-1 · Cited by 368
Halestrap, A. P. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c130008 · Cited by 339
Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes
Keller, S., König, A.-K., Marmé, F., Runz, S., Wolterink, S., Koensgen, D., Mustea, A., Sehouli, J., & Altevogt, P. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.12.028 · Cited by 300
Gallagher, S. M., Castorino, J. J., Wang, D., & Philp, N. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3184 · Cited by 288
MMP14 in sarcoma: a regulator of tumor microenvironment communication in connective tissues
Gonzalez-Molina, J., Gramolelli, S., Liao, Z., Carlson, J. W., Ojala, P. M., & Lehti, K. (2019) · Cells · doi:10.3390/cells8090991 · Cited by 89
Metadata
- Authors
- Nabeshima, K., Iwasaki, H., Koga, K., Hojo, H., Suzumiya, J., & Kikuchi, M.
- Venue
- Pathology International
- Publisher
- Wiley
- Published
- 2006-06-21
- Volume
- 56
- Issue
- 7
- Pages
- 359-367
- ISSN
- 1320-5463 (ISSN-L)
- 1440-1827
- OpenAlex
- W1970002473
- Cited by
- 298
- References
- 65
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Emmprin (basigin/CD147): Matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. https://app.cochat.ai/papers/10.1111/j.1440-1827.2006.01972.x
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- Nabeshima, K., Iwasaki, H., Koga, K., Hojo, H., Suzumiya, J., & Kikuchi, M. (2006). Emmprin (basigin/CD147): Matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathology International. https://doi.org/10.1111/j.1440-1827.2006.01972.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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