Role of monocarboxylate transporters in human cancers: state of the art

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784 · see citing works

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Inhibitory effect of tumor cell-derived lactic acid on human T cells

Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., et al. (2007) · Blood · doi:10.1182/blood-2006-07-035972 · Cited by 1,946 · see citing works

Regulation of Mammalian O ₂ Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · see citing works

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Sonveaux, P., Végran, F., Schroeder, T., Wergin, M., Verrax, J., Rabbani, Z. N., Saedeleer, C. J. D., Kennedy, K. M., Diepart, C., Jordan, B. F., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36843 · Cited by 1,633 · see citing works

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Halestrap, A. P., & Price, N. T. (1999) · Biochemical Journal · doi:10.1042/bj3430281 · Cited by 1,350 · see citing works

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Wykoff, C. C., Beasley, N. J. P., Watson, P. H., Turner, K., Pastorek, J., Sibtain, A., Wilson, G. D., Turley, H., Talks, K., Maxwell, P. H., et al. (2000) · PubMed · Cited by 1,258 · see citing works

Oncogenic alterations of metabolism

Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01344-9 · Cited by 1,106 · see citing works

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

Semenza, G. L. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80016-6 · Cited by 1,092 · see citing works

Energy metabolism in tumor cells

Moreno‐Sánchez, R., Rodríguez‐Enríquez, S., Marín‐Hernández, Á., & Saavedra, E. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05686.x · Cited by 1,086 · see citing works

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

Halestrap, A. P., & Meredith, D. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1067-2 · Cited by 1,054 · see citing works

The Transporter Classification Database (TCDB): recent advances

Saier, M. H., Reddy, V. S., Tsu, B. V., Ahmed, M. S., Li, C., & Moreno‐Hagelsieb, G. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1103 · Cited by 989 · see citing works

The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511397200 · Cited by 894 · see citing works

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis

Lu, H., Forbes, R. A., & Verma, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202487200 · Cited by 839 · see citing works

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

Walenta, S., Wetterling, M., Lehrke, M., Schwickert, G., Sundfør, K., Rofstad, E. K., & Mueller‐Klieser, W. (2000) · PubMed · Cited by 817 · see citing works

Regulation of glut1 mRNA by Hypoxia-inducible Factor-1

Chen, C., Pore, N., Behrooz, A., Ismail‐Beigi, F., & Maity, A. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010144200 · Cited by 768 · see citing works

Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle

Pellerin, L., Pellegri, G., Bittar, P. G., Charnay, Y., Bouras, C., Martin, J., Stella, N., & Magistretti, P. J. (1998) · Developmental Neuroscience · doi:10.1159/000017324 · Cited by 757 · see citing works

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

Chiche, J., Ilc, K., Laferrière, J., Trottier, E., Dayan, F., Mazure, N. M., Brahimi-Horn, M. C., & Pouysségur, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2470 · Cited by 753 · see citing works

Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

Friesema, E. C. H., Ganguly, S., Abdalla, A., Fox, J. E. M., Halestrap, A. P., & Visser, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300909200 · Cited by 725 · see citing works

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH

Švastová, E., Hulı́ková, A., Rafajová, M., Zat'ovičová, M., Gibadulinová, A., Casini, A., Cecchi, A., Scozzafava, A., Supuran, C. T., Pastorek, J., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.043 · Cited by 711 · see citing works

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

Kirk, P. B., Wilson, M. C., Heddle, C., Brown, M. H., Barclay, A. N., & Halestrap, A. P. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.3896 · Cited by 703 · see citing works

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

Semenza, G. L. (2000) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230091169186 · Cited by 651 · see citing works

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

Brizel, D. M., Schroeder, T., Scher, R. L., Walenta, S., Clough, R. W., Dewhirst, M. W., & Mueller‐Klieser, W. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01630-3 · Cited by 587 · see citing works

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

DIMMER, K.-S., Friedrich, B., Lang, F. J. W., Deitmer, J. W., & Bröer, S. (2000) · Biochemical Journal · doi:10.1042/bj3500219 · Cited by 579 · see citing works

Hypoxic Regulation of Lactate Dehydrogenase A

Firth, J. D., Ebert, B. L., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21021 · Cited by 576 · see citing works

Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1)

Greijer, A. E., van der Groep, P., Kemming, D., Shvarts, A., Semenza, G., Meijer, G. A., van de Wiel, M. A., Beliën, J. A. M., van Diest, P. J., & van der Wall, E. (2005) · The Journal of Pathology · doi:10.1002/path.1778 · Cited by 444 · see citing works

Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma

Koukourakis, M. I., Giatromanolaki, A. N., Harris, A. L., & Sivridis, E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3260 · Cited by 440 · see citing works

CD44 in Cancer Progression: Adhesion, Migration and Growth Regulation

Marhaba, R., & Zöller, M. (2004) · Journal of Molecular Histology · doi:10.1023/b:hijo.0000032354.94213.69 · Cited by 439 · see citing works

CD147 subunit of lactate/H + symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

LeFloch, R., Chiche, J., Marchiq, I., Naiken, T., Ilc, K., Murray, C. M., Critchlow, S. E., Roux, D., Simon, M., & Pouysségur, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106123108 · Cited by 431 · see citing works

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

Porporato, P. E., Dhup, S., Dadhich, R. K., Copetti, T., & Sonveaux, P. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00049 · Cited by 424 · see citing works

The Transporter Classification Database: recent advances

Saier, M. H., Yen, M. R., Noto, K., Tamang, D. G., & Elkan, C. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn862 · Cited by 414 · see citing works

Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells

Warnecke, C., Zaborowska, Z., Kurreck, J., Erdmann, V. A., Frei, U. A., Wiesener, M. S., & Eckardt, K. (2004) · The FASEB Journal · doi:10.1096/fj.04-1640fje · Cited by 395 · see citing works

Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by α-cyano-4-hydroxycinnamate ( Short Communication )

Halestrap, A. P., & Denton, R. M. (1974) · Biochemical Journal · doi:10.1042/bj1380313 · Cited by 383 · see citing works

Regulation of T Lymphocyte Metabolism

Frauwirth, K. A., & Thompson, C. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4661 · Cited by 371 · see citing works

cDNA Cloning of MCT2, a Second Monocarboxylate Transporter Expressed in Different Cells than MCT1

Garcia, C. K., Brown, M. S., Pathak, R., & Goldstein, J. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1843 · Cited by 351 · see citing works

Aerobic glycolysis during lymphocyte proliferation

Wang, T., Marquardt, C. A., & Foker, J. E. (1976) · Nature · doi:10.1038/261702a0 · Cited by 333 · see citing works

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

Fox, J. E. M., Meredith, D., & Halestrap, A. P. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00285.x · Cited by 333 · see citing works

Basigin (CD147) Is the Target for Organomercurial Inhibition of Monocarboxylate Transporter Isoforms 1 and 4

Wilson, M. C., Meredith, D., Fox, J. E. M., Manoharan, C., Davies, A. J., & Halestrap, A. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411950200 · Cited by 318 · see citing works

Lactate-proton cotransport in skeletal muscle

Juel, C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.321 · Cited by 313 · see citing works

Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH

Bröer, S., SCHNEIDER, H.-P., Bröer, A., Rahman, B., Hamprecht, B., & Deitmer, J. W. (1998) · Biochemical Journal · doi:10.1042/bj3330167 · Cited by 312 · see citing works

Emmprin (basigin/CD147): Matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression

Nabeshima, K., Iwasaki, H., Koga, K., Hojo, H., Suzumiya, J., & Kikuchi, M. (2006) · Pathology International · doi:10.1111/j.1440-1827.2006.01972.x · Cited by 298 · see citing works

Monocarboxylate Transporter 4 Regulates Maturation and Trafficking of CD147 to the Plasma Membrane in the Metastatic Breast Cancer Cell Line MDA-MB-231

Gallagher, S. M., Castorino, J. J., Wang, D., & Philp, N. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3184 · Cited by 289 · see citing works

Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease

Semenza, G. L. (2001) · Pediatric Research · doi:10.1203/00006450-200105000-00002 · Cited by 279 · see citing works

Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes

Bröer, S., Bröer, A., SCHNEIDER, H.-P., Stegen, C. F., Halestrap, A. P., & Deitmer, J. W. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3410529 · Cited by 273 · see citing works

CD147 immunoglobulin superfamily receptor function and role in pathology

Iacono, K. T., Brown, A. L., Greene, M. I., & Saouaf, S. J. (2007) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2007.08.014 · Cited by 272 · see citing works

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

Ovens, M. J., Davies, A. J., Wilson, M. C., Murray, C. M., & Halestrap, A. P. (2009) · Biochemical Journal · doi:10.1042/bj20091515 · Cited by 264 · see citing works

Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms

Hunt, T. K., Aslam, R. S., Beckert, S., Wagner, S., Ghani, Q. P., Hussain, M., Roy, S., & Sen, C. K. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1674 · Cited by 261 · see citing works

Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression

Li, Y., Zucker, S., & Toole, B. P. (2005) · Thrombosis and Haemostasis · doi:10.1160/th04-08-0536 · Cited by 260 · see citing works

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

Pinheiro, C. M., Longatto‐Filho, A., Scapulatempo‐Neto, C., Ferreira, L., Martins, S. F. F., Pellerin, L., Rodrigues, M., Alves, V. A. F., Schmitt, F. C., & Baltazar, F. (2008) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-007-0558-5 · Cited by 254 · see citing works

Correlation of high lactate levels in head and neck tumors with incidence of metastasis.

Walenta, S., Salameh, A., Lyng, H., Evensen, J. F., Mitze, M., Rofstad, E. K., & Mueller‐Klieser, W. (1997) · Europe PMC (PubMed Central) · Cited by 251 · see citing works

Expression Cloning of a Na+-independent Aromatic Amino Acid Transporter with Structural Similarity to H+/Monocarboxylate Transporters

Kim, D. K., Kanai, Y., Chairoungdua, A., Matsuo, H., Ho, S., & Endou, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009462200 · Cited by 235 · see citing works

Loss of MCT1, MCT3, and MCT4 Expression in the Retinal Pigment Epithelium and Neural Retina of the 5A11/Basigin-Null Mouse

Philp, N. J., Ochrietor, J. D., Rudoy, C., Muramatsu, T., & Linser, P. J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0552 · Cited by 235 · see citing works

18 F-FDG Uptake in Lung, Breast, and Colon Cancers: Molecular Biology Correlates and Disease Characterization

Jadvar, H., Alavi, A. A., & Gambhir, S. S. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.054098 · Cited by 226 · see citing works

Correlation of high lactate levels in human cervical cancer with incidence of metastasis.

Schwickert, G., Walenta, S., Sundfør, K., Rofstad, E. K., & Mueller-Klieser, W. (1995) · PubMed · Cited by 225 · see citing works

Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells

Toole, B. P., & Slomiany, M. G. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.009 · Cited by 220 · see citing works

Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

Gillies, R. J., & Gatenby, R. A. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9085-y · Cited by 219 · see citing works

Lactate Stimulates Fibroblast Expression of Hyaluronan and CD44: The Warburg Effect Revisited

Stern, R., Shuster, S., Neudecker, B. A., & Formby, B. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5508 · Cited by 216 · see citing works

Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells.

Floridi, A., Paggi, M. G., Marcante, M. L., Silvestrini, B., Caputo, A., & Martino, C. D. (1981) · PubMed · Cited by 211 · see citing works

Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis

Semenza, G. L. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90091-9 · Cited by 203 · see citing works

Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice

Quennet, V., Yaromina, A., Zips, D., Rosner, A., Walenta, S., Baumann, M. A., & Mueller‐Klieser, W. (2006) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2006.08.012 · Cited by 197 · see citing works

Substrate‐induced regulation of the human colonic monocarboxylate transporter, MCT1

Cuff, M. A., Lambert, D., & Shirazi‐Beechey, S. P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.014241 · Cited by 195 · see citing works

Metabolic changes during carcinogenesis: Potential impact on invasiveness

B, K. S. A., Gatenby, R. A., Gillies, R. J., Maini, P. K., & Gavaghan, D. J. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.09.010 · Cited by 191 · see citing works

Monocarboxylate transporter 1 is up‐regulated in basal‐like breast carcinoma

Pinheiro, C. M., Albergaria, A., Paredes, J., Sousa, B., Dufloth, R. M., Vieira, D. S. C., Schmitt, F. C., & Baltazar, F. (2010) · Histopathology · doi:10.1111/j.1365-2559.2010.03560.x · Cited by 188 · see citing works

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

Colen, C. B., Shen, Y., Ghoddoussi, F., Yu, P., Francis, T. B., Koch, B. J., Monterey, M. D., Galloway, M. P., Sloan, A. E., & Mathupala, S. P. (2011) · Neoplasia · doi:10.1593/neo.11134 · Cited by 187 · see citing works

Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism

Brand, K. (1985) · Biochemical Journal · doi:10.1042/bj2280353 · Cited by 187 · see citing works

Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance

Toole, B. P., & Slomiany, M. G. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.04.002 · Cited by 182 · see citing works

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells

Izumi, H., Takahashi, M., Uramoto, H., Nakayama, Y., Oyama, T., Wang, K., Sasaguri, Y., Nishizawa, S., & Kohno, K. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01908.x · Cited by 180 · see citing works

Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer

Pértega‐Gomes, N., Vizcaino, J. R., Miranda‐Gonçalves, V., Pinheiro, C. M., Silva, J., Pereira, H., Monteiro, P., Henrique, R., Reis, R. M., Lopes, C., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-312 · Cited by 180 · see citing works

Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes

de Heredia, F. P., Wood, I. S., & Trayhurn, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0750-3 · Cited by 179 · see citing works

miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1

Li, K. K., Pang, J. C., Ching, A. K.-K., Wong, C. K., Kong, X., Wang, Y., Zhou, L., Chen, Z., & Ng, H. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.02.003 · Cited by 178 · see citing works

Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE

Philp, N. J., Yoon, H., & Grollman, E. F. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.6.r1824 · Cited by 175 · see citing works

Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44

Pinheiro, C. M., Reis, R. M., Ricardo, S. A. V., Longatto‐Filho, A., Schmitt, F. C., & Baltazar, F. (2010) · BioMed Research International · doi:10.1155/2010/427694 · Cited by 171 · see citing works

The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma

Fang, J., Quiñones, Q. J., Holman, T. L., Morowitz, M. J., Wang, Q., Zhao, H., Sivo, F., Maris, J. M., & Wahl, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026245 · Cited by 171 · see citing works

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

Schneiderhan, W., Scheler, M., Holzmann, K.-H., Marx, M., Gschwend, J. E., Buchholz, M. A., Gress, T. M., Seufferlein, T. T. W., Adler, G., & Oswald, F. (2009) · Gut · doi:10.1136/gut.2009.181412 · Cited by 162 · see citing works

Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia

Deora, A. A., Philp, N. J., Hu, J. G., Bok, D., & Rodriguez-Boulan, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504419102 · Cited by 151 · see citing works

Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex

Mazurek, S., Zwerschke, W., Jansen‐Dürr, P., & EIGENBRODT, E. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3560247 · Cited by 147 · see citing works

Silencing of Monocarboxylate Transporters via Small Interfering Ribonucleic Acid Inhibits Glycolysis and Induces Cell Death in Malignant Glioma: An in Vitro Study

Mathupala, S. P., Parajuli, P., & Sloan, A. E. (2004) · Neurosurgery · doi:10.1227/01.neu.0000143034.62913.59 · Cited by 147 · see citing works

Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation

Jackson, V. N., Price, N. T., CARPENTER, L., & Halestrap, A. P. (1997) · Biochemical Journal · doi:10.1042/bj3240447 · Cited by 146 · see citing works

Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells

Slomiany, M. G., Grass, G. D., Robertson, A. D., Xiao, Y., Maria, B. L., Beeson, C. C., & Toole, B. P. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2491 · Cited by 144 · see citing works

Endothelial cell response to lactate: Implication of PAR modification of VEGF

Kumar, V. B. S., Viji, R. I., Kiran, M. S., & Sudhakaran, P. R. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20955 · Cited by 143 · see citing works

Regulation of intracellular pH in human melanoma: potential therapeutic implications.

Wahl, M., Owen, J. A., Burd, R., Herlands, R., Nogami, S. S., Rodeck, U., Berd, D., Leeper, D. B., & Owen, C. S. (2002) · PubMed · Cited by 141 · see citing works

Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy

Lambert, D., Wood, I. S., Ellis, A., & Shirazi‐Beechey, S. P. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600264 · Cited by 135 · see citing works

Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoids

Belt, J. A., Thomas, J. A., Buchsbaum, R., & Racker, E. (1979) · Biochemistry · doi:10.1021/bi00583a011 · Cited by 128 · see citing works

Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1)

Poole, R. C., Sansom, C., & Halestrap, A. P. (1996) · Biochemical Journal · doi:10.1042/bj3200817 · Cited by 128 · see citing works

A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis

Su, J., Chen, X., & Kanekura, T. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.07.034 · Cited by 128 · see citing works

The Precrystalline Cytoplasmic Granules of Alveolar Soft Part Sarcoma Contain Monocarboxylate Transporter 1 and CD147

Ladanyi, M., Antonescu, C. R., Drobnjak, M., Baren, A., Lui, M. Y., Golde, D. W., & Cordon‐Cardo, C. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62548-5 · Cited by 125 · see citing works

Functional Clarification of MCT1-Mediated Transport of Monocarboxylic Acids at the Blood-Brain Barrier Using In Vitro Cultured Cells and In Vivo BUI Studies

Kido, Y., Tamai, I., Okamoto, M., Suzuki, F., & Tsuji, A. (2000) · Pharmaceutical Research · doi:10.1023/a:1007518525161 · Cited by 123 · see citing works

Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1

Baumann, M. U., Zamudio, S., & Illsley, N. P. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00075.2007 · Cited by 123 · see citing works

Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression

Hao, J., Chen, H., Madigan, M. C., Cozzi, P. J., Beretov, J., Xiao, W., Delprado, W., Russell, P. J., & Li, Y. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605839 · Cited by 119 · see citing works

Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat

Bergersen, L. H., Jóhannsson, E., Veruki, M. L., Nagelhus, E. A., Halestrap, A. P., Sejersted, O. M., & Ottersen, O. P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00427-8 · Cited by 118 · see citing works

Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism

Baba, M., Inoue, M., Itoh, K., & Nishizawa, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.122 · Cited by 110 · see citing works

Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7

Mazurek, S., Zwerschke, W., Jansen‐Dürr, P., & EIGENBRODT, E. (2001) · Oncogene · doi:10.1038/sj.onc.1204792 · Cited by 107 · see citing works

Increasing Expression of Monocarboxylate Transporters 1 and 4 Along Progression to Invasive Cervical Carcinoma

Pinheiro, C. M., Longatto‐Filho, A., Ferreira, L., Pereira, S. M. M., Etlinger, D., Moreira, M. A. R., Jubé, L. F., Queiroz, G. S., Schmitt, F. C., & Baltazar, F. (2008) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e31817b5b40 · Cited by 102 · see citing works

Lung cancer: An organized cellular and metabolic domain

Koukourakis, M. I., Giatromanolaki, A. N., Bougioukas, G., & Sivridis, E. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.9.4635 · Cited by 100 · see citing works

The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer

Pinheiro, C. M., Longatto‐Filho, A., Simões, K., Jacob, C. E., Bresciani, C. J. C., Zilberstein, B., Cecconello, I., Alves, V. A. F., Schmitt, F. C., & Baltazar, F. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.06.018 · Cited by 95 · see citing works

Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression

Chen, H., Wang, L., Beretov, J., Hao, J., Xiao, W., & Li, Y. (2010) · Clinical & Experimental Metastasis · doi:10.1007/s10585-010-9345-9 · Cited by 92 · see citing works

Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment

Spector, J. A., Mehrara, B. J., Greenwald, J. A., Saadeh, P. B., Steinbrech, D. S., Bouletreau, P. J., Smith, L. P., & Longaker, M. T. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.1.c72 · Cited by 92 · see citing works

Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues

Froberg, M. K., Gerhart, D. Z., Enerson, B. E., Manivel, C. J., Guzman‐Paz, M., Seacotte, N., & Drewes, L. R. (2001) · Neuroreport · doi:10.1097/00001756-200103260-00030 · Cited by 85 · see citing works

Metabolic mapping with bioluminescence: basic and clinical relevance

Walenta, S., Schroeder, T., & Mueller‐Klieser, W. (2002) · Biomolecular Engineering · doi:10.1016/s1389-0344(01)00107-1 · Cited by 81 · see citing works

Inhibitory effects of statins on human monocarboxylate transporter 4

Kobayashi, M., Otsuka, Y., Itagaki, S., Hirano, T., & Iseki, K. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.02.043 · Cited by 81 · see citing works

Interaction of monocarboxylate transporter 4 with β1-integrin and its role in cell migration

Gallagher, S. M., Castorino, J. J., & Philp, N. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00430.2008 · Cited by 79 · see citing works

Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies.

Ben-Horin, H., Tassini, M., Vivi, A., Navon, G., & Kaplan, O. (1995) · PubMed · Cited by 78 · see citing works

METABOLIC REMODELING OF MALIGNANT GLIOMAS FOR ENHANCED SENSITIZATION DURING RADIOTHERAPY

Colen, C. B., Seraji‐Bozorgzad, N., Marples, B., Galloway, M. P., Sloan, A. E., & Mathupala, S. P. (2006) · Neurosurgery · doi:10.1227/01.neu.0000249218.65332.bf · Cited by 75 · see citing works

Flavonoids Modulate Monocarboxylate Transporter-1-Mediated Transport of γ-Hydroxybutyrate in Vitro and in Vivo

Wang, Q., & Morris, M. E. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.012369 · Cited by 75 · see citing works

Reduced Expression of GNA11 and Silencing of MCT1 in Human Breast Cancers

Asada, K., Miyamoto, K., Fukutomi, T., Tsuda, H., Yagi, Y., Wakazono, K., Oishi, S., Fukui, H., Sügimura, T., & Ushijima, T. (2003) · Oncology · doi:10.1159/000070297 · Cited by 73 · see citing works

Monocarboxylate Transporters 1 and 4 Are Associated with CD147 in Cervical Carcinoma

Pinheiro, C. M., Longatto‐Filho, A., Pereira, S. M. M., Etlinger, D., Moreira, M. A. R., Jubé, L. F., Queiroz, G. S., Schmitt, F. C., & Baltazar, F. (2009) · Disease Markers · doi:10.1155/2009/169678 · Cited by 73 · see citing works

Determination of Transport Kinetics of Chick MCT3 Monocarboxylate Transporter from Retinal Pigment Epithelium by Expression in Genetically Modified Yeast

Grollman, E. F., Philp, N. J., McPhie, P., Ward, R. D., & Sauer, B. (2000) · Biochemistry · doi:10.1021/bi000464+ · Cited by 72 · see citing works

Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma.

Pinheiro, C. M., Longatto‐Filho, A., Pereira, S. M. M., et al. (2009) · PubMed · doi:10.3233/dma-2009-0596 · Cited by 64 · see citing works

Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function

Carpenter, L., Poole, R. C., & Halestrap, A. P. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00254-5 · Cited by 62 · see citing works

Substrate and inhibitor specificity of monocarboxylate transport into heart cells and erythrocytes. Further evidence for the existence of two distinct carriers

Poole, R. C., Cranmer, S. L., Halestrap, A. P., & Levi, A. J. (1990) · Biochemical Journal · doi:10.1042/bj2690827 · Cited by 60 · see citing works

Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells.

Mazurek, S., Grimm, H., Oehmke, M. J., Weisse, G., Teigelkamp, S., & EIGENBRODT, E. (2000) · PubMed · Cited by 55 · see citing works

Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification

Ben‐Yoseph, O., Lyons, J. C., Song, C. W., & Ross, B. D. (1998) · Journal of Neuro-Oncology · doi:10.1023/a:1005819604858 · Cited by 50 · see citing works

Tumor Microenvironment Modulates Hyaluronan Expression: The Lactate Effect

Rudrabhatla, S. R., Mahaffey, C. L., & Mummert, M. E. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700255 · Cited by 44 · see citing works

Co-expression of a mammalian accessory trafficking protein enables functional expression of the rat MCT1 monocarboxylate transporter in

MAKUC, J., Cappellaro, C., & Boles, E. (2004) · FEMS Yeast Research · doi:10.1016/j.femsyr.2004.06.003 · Cited by 29 · see citing works

Identification of a monocarboxylate transporter isoform type 1 (MCT1) on the luminal membrane of human and pig colon

Ritzhaupt, A., Wood, I. S., Ellis, A., Hosie, K. B., & Shirazi‐Beechey, S. P. (1998) · Biochemical Society Transactions · doi:10.1042/bst026s120 · Cited by 26 · see citing works

Tumor glycolysis as a target for cancer therapy: progress and prospects

Ganapathy‐Kanniappan, S., & Geschwind, J.-F. H. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-152 · Cited by 1,402 · see citing works

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works

Targeting Metabolism for Cancer Therapy

Luengo, A., Gui, D. Y., & Vander Heiden, M. G. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.08.028 · Cited by 971 · see citing works

Monocarboxylate transporters in cancer

Payen, V. L., Mina, E., Hée, V. F. V., Porporato, P. E., & Sonveaux, P. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.07.006 · Cited by 662 · see citing works

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

San-Millán, I., & Brooks, G. A. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw127 · Cited by 612 · see citing works

Disrupting proton dynamics and energy metabolism for cancer therapy

Parks, S. K., Chiche, J., & Pouysségur, J. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3579 · Cited by 613 · see citing works

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

Abdel-Wahab, A. F., Mahmoud, W., & Al-Harizy, R. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104511 · Cited by 589 · see citing works

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

Thakur, A., Singla, R., & Jaitak, V. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.07.010 · Cited by 491 · see citing works

3D cell culture systems modeling tumor growth determinants in cancer target discovery

Thoma, C. R., Zimmermann, M., Agarkova, I., Kelm, J. M., & Krek, W. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.03.001 · Cited by 478 · see citing works

Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease

Felmlee, M. A., Jones, R. S., Rodriguez‐Cruz, V., Follman, K. E., & Morris, M. E. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018762 · Cited by 483 · see citing works

Cancer-associated adipocytes: key players in breast cancer progression

Wu, Q., Li, B., Li, Z., Li, J., Sun, S., & Sun, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0778-6 · Cited by 462 · see citing works

Role of Monocarboxylate Transporters in Drug Delivery to the Brain

Vijay, N., & Morris, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990462 · Cited by 408 · see citing works

Monocarboxylate transporters in the brain and in cancer

Pérez‐Escuredo, J., Hée, V. F. V., Sboarina, M., Falces, J., Payen, V. L., Pellerin, L., & Sonveaux, P. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.013 · Cited by 407 · see citing works

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

Doherty, J. R., Yang, C., Scott, K. E. N., Cameron, M. D., Fallahi, M., Li, W., Hall, M. A., Amelio, A. L., Mishra, J. K., Li, F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-2034 · Cited by 399 · see citing works

A guide to plasma membrane solute carrier proteins

Pizzagalli, M. D., Bensimon, A., & Superti‐Furga, G. (2020) · FEBS Journal · doi:10.1111/febs.15531 · Cited by 380 · see citing works

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

Polański, R., Hodgkinson, C. L., Fusi, A., Nonaka, D., Priest, L., Kelly, P., Trapani, F., Bishop, P. W., White, A., Critchlow, S. E., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2270 · Cited by 378 · see citing works

Monocarboxylic Acid Transport

Halestrap, A. P. (2013) · Comprehensive physiology · doi:10.1002/cphy.c130008 · Cited by 389 · see citing works

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters

Marchiq, I., & Pouysségur, J. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1307-x · Cited by 300 · see citing works

Causes, consequences, and therapy of tumors acidosis

Pillai, S., Damaghi, M., Marunaka, Y., Spugnini, E. P., Fais, S., & Gillies, R. J. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09792-7 · Cited by 282 · see citing works

Short‐Chain Fatty Acid Transporters: Role in Colonic Homeostasis

Sivaprakasam, S., Bhutia, Y. D., Yang, S., & Ganapathy, V. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170014 · Cited by 321 · see citing works

Recent advances in smart hydrogels for biomedical applications: From self-assembly to functional approaches

Ferreira, N. N., Ferreira, L. M. B., Cardoso, V. M. D. O., Boni, F. I., de Souza, A. L. R., & Gremião, M. P. D. (2017) · European Polymer Journal · doi:10.1016/j.eurpolymj.2017.12.004 · Cited by 245 · see citing works

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

Zhang, L., Yao, Y., Zhang, S., Liu, Y., Guo, H., Ahmed, M., Bell, T., Zhang, H., Han, G., Lorence, E., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau1167 · Cited by 233 · see citing works

Carbonic anhydrase IX and acid transport in cancer

Becker, H. M. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0642-z · Cited by 232 · see citing works

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

Baek, G., Tse, Y. F., Hu, Z., Cox, D., Buboltz, N., McCue, P. A., Yeo, C. J., White, M. A., DeBerardinis, R. J., Knudsen, E. S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.025 · Cited by 221 · see citing works

Molecular intricacies of aerobic glycolysis in cancer: Current insights into the classic metabolic phenotype

Ganapathy-Kanniappan, S. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1556578 · Cited by 216 · see citing works

Cancer metabolism in space and time: Beyond the Warburg effect

Danhier, P., Bański, P., Payen, V. L., Grasso, D., Ippolito, L., Sonveaux, P., & Porporato, P. E. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.02.001 · Cited by 214 · see citing works

Metabolic reprogramming in renal cancer: Events of a metabolic disease

Chakraborty, S., Balan, M., Sabarwal, A., Choueiri, T. K., & Pal, S. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188559 · Cited by 208 · see citing works

The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

Lis, P., Dyląg, M., Niedźwiecka, K., Ko, Y. H., Pedersen, P. L., Goffeau, A., & Ułaszewski, S. (2016) · Molecules · doi:10.3390/molecules21121730 · Cited by 201 · see citing works

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

Wang, G., Yu, Y., Wang, Y., Wang, J., Guan, R., Sun, Y., Shi, F., Gao, J., & Fu, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28436 · Cited by 199 · see citing works

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

McCleland, M. L., Adler, A. S., Shang, Y., Hunsaker, T., Truong, T., Peterson, D., Torres, E., Li, L., Haley, B., Stéphan, J.-P., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1098 · Cited by 192 · see citing works

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Samanta, D., & Semenza, G. L. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.002 · Cited by 190 · see citing works

Targeting monocarboxylate transporters (MCTs) in cancer: How close are we to the clinics?

Singh, M., Afonso, J., Sharma, D., Gupta, R., Kumar, V., Rani, R., Baltazar, F., & Kumar, V. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.01.007 · Cited by 187 · see citing works

Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment

Battogtokh, G., Cho, Y., Lee, J. Y., Lee, H. S., & Kang, H. C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00922 · Cited by 177 · see citing works

Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin

Marchiq, I., LeFloch, R., Roux, D., Simon, M., & Pouysségur, J. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2260 · Cited by 175 · see citing works

Are Integrins Still Practicable Targets for Anti-Cancer Therapy?

Alday-Parejo, B., Stupp, R., & Rüegg, C. (2019) · Cancers · doi:10.3390/cancers11070978 · Cited by 175 · see citing works

‘Warburg effect’ controls tumor growth, bacterial, viral infections and immunity – Genetic deconstruction and therapeutic perspectives

Pouysségur, J., Marchiq, I., Parks, S. K., Durivault, J., Ždralević, M., & Vučetić, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.07.004 · Cited by 172 · see citing works

Histone lactylation: from tumor lactate metabolism to epigenetic regulation

Yu, X., Yang, J., Xu, J., Pan, H., Wang, W. J., Yu, X., & Shi, S. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.91492 · Cited by 165 · see citing works

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

Riedmaier, A. E., Fisel, P., Nies, A. T., Schaeffeler, E., & Schwab, M. G. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.11.005 · Cited by 161 · see citing works

Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function

Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Martinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0108 · Cited by 158 · see citing works

Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies

Zhang, Y., Li, Q., Huang, Z., Li, B., Nice, E. C., Huang, C., Wei, L., & Zou, B. (2022) · Cancers · doi:10.3390/cancers14194568 · Cited by 144 · see citing works

The role of lactate in cardiovascular diseases

Ouyang, J., Wang, H., & Huang, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01350-7 · Cited by 141 · see citing works

Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung Adenocarcinomas

McCleland, M. L., Adler, A. S., Deming, L., Cosino, E., Lee, L. B., Blackwood, E. M., Solon, M., Tao, J., Li, L., Shames, D. S., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2638 · Cited by 131 · see citing works

Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer

Ata, R., & Antonescu, C. N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010189 · Cited by 136 · see citing works

MCT4 blockade increases the efficacy of immune checkpoint blockade

Babl, N., Decking, S.-M., Voll, F., Althammer, M., Sala-Hojman, A., Ferretti, R., Korf, C., Schmidl, C., Schmidleithner, L. M., Nerb, B., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007349 · Cited by 141 · see citing works

Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

Stock, C. M., & Pedersen, S. F. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.12.001 · Cited by 132 · see citing works

A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy

Pértega‐Gomes, N., Felisbino, S. L., Massie, C. E., Vizcaino, J. R., Coelho, R., Sandi, C., Simoes‐Sousa, S., Jurmeister, S., Ramos‐Montoya, A., Asim, M., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4547 · Cited by 128 · see citing works

Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas

Miranda‐Gonçalves, V., Granja, S., Martinho, O., Honavar, M., Pojo, M., Costa, B. M., Pires, M. M., Pinheiro, C., Cordeiro, M., Bebiano, G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10114 · Cited by 128 · see citing works

Antitumor Activity of 7-Aminocarboxycoumarin Derivatives, a New Class of Potent Inhibitors of Lactate Influx but Not Efflux

Draoui, N., Schicke, O., Seront, E., Bouzin, C., Sonveaux, P., Riant, O., & Féron, O. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0653 · Cited by 125 · see citing works

Na + /H + antiporter (NHE1) and lactate/H + symporters (MCTs) in pH homeostasis and cancer metabolism

Counillon, L., Bouret, Y., Marchiq, I., & Pouysségur, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.02.018 · Cited by 122 · see citing works

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

Long, Y., Tsai, W.-B., Wangpaichitr, M., Tsukamoto, T., Savaraj, N., Feun, L. G., & Kuo, M. T. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0302 · Cited by 121 · see citing works

Role of pH i , and proton transporters in oncogene-driven neoplastic transformation

Reshkin, S. J., Greco, M. R., & Cardone, R. A. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0100 · Cited by 121 · see citing works

Metabolic reprogramming results in abnormal glycolysis in gastric cancer: a review

Liu, Y., Zhang, Z., Wang, J., Chen, C., Tang, X., Zhu, J., & Liu, J. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s189687 · Cited by 122 · see citing works

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

Fisel, P., Schaeffeler, E., & Schwab, M. G. (2018) · Clinical and Translational Science · doi:10.1111/cts.12551 · Cited by 118 · see citing works

A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

Pértega‐Gomes, N., Vizcaino, J. R., Attig, J., Jurmeister, S., Lopes, C., & Baltazar, F. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-352 · Cited by 119 · see citing works

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

Bhutia, Y. D., Babu, E., Ramachandran, S., Yang, S., Thangaraju, M., & Ganapathy, V. (2016) · Biochemical Journal · doi:10.1042/bj20150751 · Cited by 115 · see citing works

The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications

Gomes, S., Oliveira, C. S., Azevedo‐Silva, J., Casanova, M. R., Barreto, J., Pereira, H., Chaves, S. R., Rodrigues, L. R., Casal, M., Côrte‐Real, M., et al. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180530102050 · Cited by 116 · see citing works

Monocarboxylate transporters as targets and mediators in cancer therapy response.

Baltazar, F., Pinheiro, C. M., Morais-Santos, F., Azevedo‐Silva, J., Queirós, O., Preto, A., & Casal, M. (2014) · PubMed · doi:10.14670/hh-29.1511 · Cited by 114 · see citing works

Nutrient transporters: the Achilles’ heel of anabolism

McCracken, A. N., & Edinger, A. L. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.01.002 · Cited by 113 · see citing works

3-bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective “small molecule” anti-cancer agent taken from labside to bedside: introduction to a special issue

Pedersen, P. L. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9425-4 · Cited by 112 · see citing works

Biocompatible, Crystalline, and Amorphous Bismuth-Based Metal–Organic Frameworks for Drug Delivery

Orellana‐Tavra, C., Köppen, M., Li, A., Stock, N., & Fairen‐Jiménez, D. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b21692 · Cited by 111 · see citing works

DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome

Fisel, P., Kruck, S., Winter, S., Bedke, J., Hennenlotter, J., Nies, A. T., Scharpf, M. O., Fend, F., Stenzl, A., Schwab, M. G., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1180 · Cited by 109 · see citing works

Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

Li, B., & Simon, M. C. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3629 · Cited by 106 · see citing works

Value of pH regulators in the diagnosis, prognosis and treatment of cancer

Granja, S., Tavares‐Valente, D., Queirós, O., & Baltazar, F. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.12.003 · Cited by 109 · see citing works

Targeting myeloid-derived suppressor cells for cancer immunotherapy

Liu, Y., Wei, G., Cheng, W. A., Dong, Z., Sun, H., Lee, V. Y., Cha, S.-C., Smith, D. L., Kwak, L. W., & Qin, H. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2175-3 · Cited by 107 · see citing works

Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells

Guan, X., Rodriguez‐Cruz, V., & Morris, M. E. (2019) · The AAPS Journal · doi:10.1208/s12248-018-0279-5 · Cited by 108 · see citing works

The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer

Spencer, N. Y., & Stanton, R. C. (2019) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2019.04.007 · Cited by 107 · see citing works

The SLC16A Family of Monocarboxylate Transporters (MCTs)—Physiology and Function in Cellular Metabolism, pH Homeostasis, and Fluid Transport

Adijanto, J., & Philp, N. J. (2012) · Current topics in membranes · doi:10.1016/b978-0-12-394316-3.00009-0 · Cited by 101 · see citing works

An overview of MCT1 and MCT4 in GBM: small molecule transporters with large implications.

Park, S. J., Smith, C. P., Wilbur, R. R., Cain, C. P., Kallu, S. R., Valasapalli, S., Sahoo, A., Guda, M. R., Tsung, A. J., & Velpula, K. K. (2018) · Europe PMC (PubMed Central) · Cited by 99 · see citing works

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression

Sanità, P., Capulli, M., Teti, A. M., Galatioto, G. P., Vicentini, C., Chiarugi, P., Bologna, M., & Angelucci, A. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-154 · Cited by 102 · see citing works

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer

Daniel, C., Bell, C., Burton, C., Harguindey, S., Reshkin, S. J., & Rauch, C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.01.020 · Cited by 102 · see citing works

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

Andersen, A. P., Moreira, J. M. A., & Pedersen, S. F. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0098 · Cited by 101 · see citing works

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

Jones, R., & Morris, M. (2016) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.418 · Cited by 100 · see citing works

Cancer-derived extracellular succinate: a driver of cancer metastasis

Kuo, C.-C., Wu, J.-Y., & Wu, K. K. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00878-z · Cited by 104 · see citing works

Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis

Bovenzi, C. D., Hamilton, J., Tassone, P. T., Johnson, J. M., Cognetti, D. M., Luginbuhl, A., Keane, W. M., Zhan, T., Tuluc, M., Bar‐Ad, V., et al. (2015) · BioMed Research International · doi:10.1155/2015/242437 · Cited by 96 · see citing works

Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer

Sprowl-Tanio, S., Habowski, A. N., Pate, K. T., McQuade, M. M., Wang, K., Edwards, R. A., Grün, F., Lyou, Y., & Waterman, M. L. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0159-3 · Cited by 96 · see citing works

Enhanced glycolysis, regulated by HIF-1α via MCT-4, promotes inflammation in arsenite-induced carcinogenesis

Luo, F., Zou, Z., Liu, X., Ling, M., Wang, Q., Wang, Q., Lu, L., Shi, L., Liu, Y., Liu, Q., et al. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx034 · Cited by 94 · see citing works

Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile

Vaz, C. V., Alves, M. G., Marques, R., Moreira, P. I., Oliveira, P. F., Maia, C. J., & Socorro, S. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.013 · Cited by 94 · see citing works

Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy

Mabate, B., Daub, C. D., Malgas, S., Edkins, A. L., & Pletschke, B. I. (2021) · Marine Drugs · doi:10.3390/md19010030 · Cited by 92 · see citing works

Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)

Kobayashi, M., Narumi, K., Furugen, A., & Iseki, K. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107862 · Cited by 89 · see citing works

Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells

Kong, S. C., Nøhr‐Nielsen, A., Zeeberg, K., Reshkin, S. J., Hoffmann, E. K., Novak, I., & Pedersen, S. F. (2016) · Pancreas · doi:10.1097/mpa.0000000000000571 · Cited by 89 · see citing works

CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells

Walters, D. K., Arendt, B. K., & Jelinek, D. F. (2013) · Cell Cycle · doi:10.4161/cc.26193 · Cited by 86 · see citing works

Tumor metabolism, cancer cell transporters, and microenvironmental resistance

Alfarouk, K. O. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2016.1140753 · Cited by 88 · see citing works

Cell-Autonomous Metabolic Reprogramming in Hypoxia

Schito, L., & Rey, S. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.10.006 · Cited by 82 · see citing works

Monocarboxylate Transporters 1–4 in NSCLC: MCT1 Is an Independent Prognostic Marker for Survival

Eilertsen, M., Andersen, S., Al‐Saad, S., Kiselev, Y., Dønnem, T., Stenvold, H., Pettersen, I., Al-Shibli, K. I., Richardsen, E. H., Busund, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105038 · Cited by 84 · see citing works

Metabolic tricks of cancer cells

Hönigová, K., Navrátil, J., Peltanová, B., Polanska, H. H., Raudenská, M., & Masařík, M. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188705 · Cited by 84 · see citing works

Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death

de Alteriis, E., Cartenì, F., Parascandola, P., Serpa, J., & Mazzoleni, S. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1442622 · Cited by 80 · see citing works

Lactate transporters as therapeutic targets in cancer and inflammatory diseases

Pucino, V., Cucchi, D., & Mauro, C. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1511706 · Cited by 83 · see citing works

Post-translational protein lactylation modification in health and diseases: a double-edged sword

Gong, H., Zhong, H., Cheng, L., Li, L., & Zhang, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04842-9 · Cited by 88 · see citing works

CD147 and MCT1‐potential partners in bladder cancer aggressiveness and cisplatin resistance

Afonso, J., Santos, L. L., Miranda‐Gonçalves, V., Morais, A., Amaro, T., Longatto‐Filho, A., & Baltazar, F. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22222 · Cited by 79 · see citing works

Glucose addiction in cancer therapy: advances and drawbacks

Granja, S., Pinheiro, C. M., Reis, R. M., Martinho, O., & Baltazar, F. (2015) · Current Drug Metabolism · doi:10.2174/1389200216666150602145145 · Cited by 75 · see citing works

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export

Parks, S. K., Cormerais, Y., Marchiq, I., & Pouysségur, J. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.12.001 · Cited by 76 · see citing works

Links between cancer metabolism and cisplatin resistance

Cocetta, V., Ragazzi, E., & Montopoli, M. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.01.005 · Cited by 75 · see citing works

Tumor microenvironmental nutrients, cellular responses, and cancer

Lobel, G. P., Jiang, Y., & Simon, M. C. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.011 · Cited by 74 · see citing works

Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness

Ward, C., Meehan, J., Gray, M., Kunkler, I. H., Langdon, S. P., & Argyle, D. J. (2018) · Metabolites · doi:10.3390/metabo8010013 · Cited by 76 · see citing works

Colorectal Cancer Cells Increase the Production of Short Chain Fatty Acids by Propionibacterium freudenreichii Impacting on Cancer Cells Survival

Casanova, M. R., Azevedo‐Silva, J., Rodrigues, L. R., & Preto, A. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00044 · Cited by 74 · see citing works

Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer

Schneider, L. S., von Schwarzenberg, K., Lehr, T., Ulrich, M. P., Kubisch-Dohmen, R., Liebl, J., Trauner, D. H., Menche, D., & Vollmar, A. M. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2097 · Cited by 72 · see citing works

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

Draoui, N., Schicke, O., Fernandes, A. E., Drozak, X., Nahra, F., Dumont, A. O., Douxfils, J., Hermans, E., Dogné, J., Corbau, R., et al. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.09.010 · Cited by 72 · see citing works

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

Azevedo‐Silva, J., Queirós, O., Baltazar, F., Ułaszewski, S., Goffeau, A., Ko, Y. H., Pedersen, P. L., Preto, A., & Casal, M. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9670-z · Cited by 74 · see citing works

Attacking the supply wagons to starve cancer cells to death

Selwan, E. M., Finicle, B. T., Kim, S. M., & Edinger, A. L. (2016) · FEBS Letters · doi:10.1002/1873-3468.12121 · Cited by 70 · see citing works

Monocarboxylate transporters as targets\n\t\t\t\t and mediators in cancer therapy response

Baltazar, F., Pinheiro, C., Morais-Santos, F., Azevedo-Silva, J., Queirós, O., Preto, A., & Casal, M. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Function of the Monocarboxylate Transporter in Tumors

De, Y. (2013) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao

Monocarboxylate transporters as targets and mediators in cancer therapy response.

Baltazar, F., Pinheiro, C. M., Morais-Santos, F., Azevedo‐Silva, J., Queirós, O., Preto, A., & Casal, M. (2014) · PubMed · doi:10.14670/hh-29.1511 · Cited by 114 · see citing works

Summary. Monocarboxylate transporters (MCTs)

(2016)

Monocarboxylate transporters in physiology and cancer: from fundamentals to clinical translation

Afonso, J., Pereira-Vieira, J., Miranda‐Gonçalves, V., Granja, S., Pinheiro, C. M., & Baltazar, F. (2026) · Physiological Reviews · doi:10.1152/physrev.00004.2026