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Role of antioxidants in the treatment of male infertility
Open accessAbstract
Male infertility continues to be a clinical challenge of increasing significance. While male factors such as decreased semen quality are responsible for 25% of all infertility issues, the etiology of suboptimal semen quality is poorly understood. Many physiological, environmental, and genetic factors have been implicated, including oxidative stress. Oxidative stress is induced by reactive oxygen species (ROS), or free radicals, and although ROS are required for critical aspects of sperm function, excessive levels of ROS can negatively impact sperm quality. The origin of ROS generation, and the etiologies of increased ROS in men with suboptimal sperm quality have only recently been elucidated, offering multiple targets for potential therapy. Here, we present a critical review of the literature describing the role of oxidative stress on decreased sperm function, as well as the role of antioxidants in the treatment of male factor infertility.
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“According to Salas-Huetos et al., oxidative stress can be reduced by the antioxidant properties of fruits and vegetables, since these antioxidants act as scavengers and reduce reactive oxygen species [89,90].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [89]
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Metadata
- Authors
- Kefer, J. C., Agarwal, A., & Sabanegh, E.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Agarwal, Ashok
- ORCID
- Agarwal, Ashok
- Venue
- International Journal of Urology
- Publisher
- Wiley
- Published
- 2009-04-28
- Volume
- 16
- Issue
- 5
- Pages
- 449-457
- ISSN
- 0919-8172 (ISSN-L)
- 1442-2042
- OpenAlex
- W2166623820
- Cited by
- 273
- References
- 97
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 20 · 2022: 16 · 2021: 14 · 2020: 21 · 2019: 17 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 19 · 2012: 19
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Urology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- male infertility, antioxidants, oxidative stress, reactive oxygen species, semen quality, male factor infertility, antioxidant therapy, sperm function
- MeSH terms
- Antioxidants, Humans, Infertility, Male, Male, Spermatozoa, Oxidants, Oxidative Stress
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