Evidence for differential modulation of conditioned aversion and fear‐conditioned analgesia by CB 1 receptors
Open accessAbstract
Fear-conditioned analgesia is an important survival response mediated by substrates controlling nociception and aversion. Cannabinoid(1) (CB(1)) receptors play an important role in nociception and aversion. However, their role in fear-conditioned analgesia has not been investigated. This study investigated the effects of systemic administration of the CB(1) receptor antagonist, SR141716A (1 mg/kg, i.p.), on fear-conditioned analgesia and conditioned aversion in rats. Twenty-four hours after receiving footshock, rats exhibited reduced formalin-evoked nociceptive behaviour, increased freezing and increased defecation when tested in the footshock apparatus, compared with non-footshocked formalin-injected rats. SR141716A attenuated fear-conditioned analgesia, freezing and defecation. Importantly, SR141716A had no effect on formalin-evoked nociceptive behaviour over an equivalent time period in rats not receiving footshock. SR141716A had no effect on contextually induced freezing during the first half of the test trial in rats receiving intra-plantar injection of saline. Administration of SR1417176A did, however, attenuate short-term extinction of contextually induced freezing and ultrasound emission in rats receiving intra-plantar saline, compared with vehicle-treated saline controls. These data suggest an important role for the CB(1) receptor in mediating fear-conditioned analgesia and provide evidence for differential modulation of conditioned aversive behaviour by CB(1) receptors during tonic, persistent pain.
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Infusing SR141716A directly into the BLA or mPFC is sufficient to impair cued fear extinction in rats.
“Subsequent studies showed that infusing SR141716A directly into the BLA (or mPFC [90]) was sufficient to impair a cued fear extinction in rats [91,92].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [92]
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- Authors
- Finn, D. P., Beckett, S. R. G., Richardson, D., Kendall, D. A., Marsden, C. A., & Chapman, V.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Finn, D. P.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2004-07-15
- Volume
- 20
- Issue
- 3
- Pages
- 848-852
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2142509975
- Cited by
- 66
- References
- 30
- Citations by year
- 2026: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- University of Galway Research Repository (submittedVersion, cc-by)
- Research Repository UCD (University College Dublin) (cc-by)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- CB1 receptor, conditioned aversion, SR141716A, nociception, formalin-induced pain, footshock, freezing behavior, defecation, extinction
- MeSH terms
- Rimonabant, Analgesia, Analysis of Variance, Animals, Avoidance Learning, Behavior, Animal, Conditioning, Psychological, Fear, Male, Motor Activity, Pain Measurement, Piperidines, Pyrazoles, Time Factors, Receptor, Cannabinoid, CB1, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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