The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats

Roche, Michelle; O'Connor, Emer; Diskin, Catherine; Finn, David P.

doi:10.1111/j.1460-9568.2007.05861.x

Cited by 83Cannabis and Cannabinoid ResearchMemory and Neural MechanismsPain Mechanisms and Treatments

The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats

Roche, Michelle, O'Connor, Emer, Diskin, Catherine, Finn, David P.·2007·European Journal of Neuroscience

DOI 10.1111/j.1460-9568.2007.05861.x

Open this paper in CoChat — free account

Abstract

The endocannabinoid system mediates analgesia expressed following exposure to conditioned or unconditioned aversive stimuli, and controls the extinction of conditioned aversive behaviour. The present study investigated the effects of administration of the cannabinoid(1) (CB(1)) receptor antagonist SR141716A into the right basolateral amygdala (BLA) on expression of conditioned fear, formalin-evoked nociceptive behaviour, fear-conditioned analgesia and associated alterations in monoamine levels in discrete rat brain areas. Re-exposure to a context previously paired with footshock significantly reduced formalin-evoked nociceptive behaviour. Intra-BLA administration of SR141716A did not attenuate fear-conditioned analgesia, but reduced formalin-evoked nociceptive behaviour and attenuated the formalin-induced decrease in freezing and 22-kHz ultrasonic vocalizations in the early part of the trial. Furthermore, intra-BLA SR141716A significantly prolonged the duration of these fear-related behaviours in fear-conditioned rats not receiving formalin. Fear-conditioned analgesia was accompanied by increased homovanillic acid (HVA) : dopamine (DA) ratio and reduced serotonin (5-HT) in the cerebellum, an effect not altered by SR141716A. SR141716A-induced analgesia was accompanied by reduced DA, increased HVA : DA ratio and reduced 5-HT levels in the cerebellum, increased hippocampal HVA levels and increased 5-hydroxyindole-3-acetic acid (5-HIAA) in the amygdaloid cortex. The SR141716A-induced prolongation of contextually induced aversive behaviour was accompanied by reduced DA and 3,4-dihydroxyphenylacetic acid (DOPAC), levels in the hippocampus, and increased DA and 5-HIAA in the periaqueductal grey. These data suggest an important role for CB(1) receptors in the right BLA in mediating short-term extinction of conditioned aversive behaviour but not fear-conditioned analgesia. The results also enhance our understanding of endocannabinoid-monoamine interactions of relevance to conditioned fear and associated analgesia.

Integrity signals

Registry

Crossref · 10.1111/j.1460-9568.2007.05861.x

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Infusing SR141716A directly into the BLA or mPFC is sufficient to impair cued fear extinction in rats.
“Subsequent studies showed that infusing SR141716A directly into the BLA (or mPFC [90]) was sufficient to impair a cued fear extinction in rats [91,92].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [91]

The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
Descending control of pain
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142 · see citing works
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586 · see citing works
Control of pain initiation by endogenous cannabinoids
Calignano, A., Rana, G. L., Giuffrida, A., & Piomelli, D. (1998) · Nature · doi:10.1038/28393 · Cited by 1,055 · see citing works
An endocannabinoid mechanism for stress-induced analgesia
Hohmann, A. G., Suplita, R. L., Bolton, N. M., Neely, M. H., Fegley, D., Mangieri, R., Krey, J. F., Michael Walker, J., Holmes, P. V., Crystal, J. D., et al. (2005) · Nature · doi:10.1038/nature03658 · Cited by 778 · see citing works
Cannabinoid receptors and pain
Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works
Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission
Katona, I., Rancz, E. A., Acsády, L., Ledent, C., Mackie, K., Hájos, N., & Freund, T. F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09506.2001 · Cited by 668 · cited 2× · see citing works
“interneurons in the BLA but absent from the central amygdaloid nucleus (Herkenham et al., 1990; Tsou et al., 1998; Katona et al., 2001).”
Background
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
Cristino, L., PETROCELLIS, L. D., Pryce, G., Baker, D., Guglielmotti, V., & Marzo, V. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.074 · Cited by 489 · see citing works
Pain modulation by release of the endogenous cannabinoid anandamide
Walker, J. M., Huang, S. M., Strangman, N. M., Tsou, K., & Sañudo-Peña, M. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12198 · Cited by 486 · see citing works
An analgesia circuit activated by cannabinoids
Meng, I. D., Manning, B. H., Martin, W. J., & Fields, H. L. (1998) · Nature · doi:10.1038/26481 · Cited by 411 · cited 2× · see citing works
“, 2006; for recent review, see Chhatwal & Ressler, 2007) and nociception (Calignano et al., 1998; Meng et al., 1998; Strangman et al., 1998; for recent review, see Pertwee, 2001; Finn & Chapman, 2004; Hohmann & Suplita, 2006).”
Background
Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
Chhatwal, J. P., Davis, M., Maguschak, K. A., & Ressler, K. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300655 · Cited by 376 · see citing works
Origin of the dopaminergic innervation of the central extended amygdala and accumbens shell: A combined retrograde tracing and immunohistochemical study in the rat
Hasue, R. H., & Shammah‐Lagnado, S. J. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10420 · Cited by 306 · see citing works
Elevation of Endocannabinoid Levels in the Ventrolateral Periaqueductal Grey through Inhibition of Fatty Acid Amide Hydrolase Affects Descending Nociceptive Pathways via Both Cannabinoid Receptor Type 1 and Transient Receptor Potential Vanilloid Type-1 Receptors
Maione, S., Bisogno, T., de Novellis, V., Palazzo, E., Cristino, L., Valenti, M., Petrosino, S., Guglielmotti, V., Rossi, F., & Marzo, V. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093286 · Cited by 293 · see citing works
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions
Tzavara, E. T., Davis, R. J., Perry, K. W., Li, X., Salhoff, C. R., Bymaster, F. P., Witkin, J. M., & Nomikos, G. G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705100 · Cited by 270 · see citing works
Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats.
Helmstetter, F. J., & Bellgowan, P. S. F. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.5.1005 · Cited by 265 · see citing works
The dorsal raphe: An important nucleus in pain modulation
Wang, Q., & Nakai, Y. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90143-0 · Cited by 264 · see citing works
Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain
Inoue, T., Tsuchiya, K., & Koyama, T. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90243-7 · Cited by 262 · see citing works
Auditory Thalamus, Dorsal Hippocampus, Basolateral Amygdala, and Perirhinal Cortex Role in the Consolidation of Conditioned Freezing to Context and to Acoustic Conditioned Stimulus in the Rat
Sacchetti, B., Lorenzini, C. A., Baldi, E., Tassoni, G., & Bucherelli, C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09570.1999 · Cited by 243 · see citing works
The involvement of dopamine in nociception: the role of D1 and D2 receptors in the dorsolateral striatum
Magnusson, J. E., & Fisher, K. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02396-3 · Cited by 223 · see citing works
Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats.
Helmstetter, F. J., & Bellgowan, P. S. F. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.5.1005 · Cited by 219 · see citing works
Endocannabinoid mechanisms of pain modulation
Hohmann, A. G., & Suplita, R. L. (2006) · The AAPS Journal · doi:10.1208/aapsj080479 · Cited by 213 · see citing works
Long-term synaptic changes induced in the cerebellar cortex by fear conditioning.
Sacchetti, B., Scelfo, B., Tempia, F., & Strata, P. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.012 · Cited by 201 · see citing works
Interleukin-2 Suppression by 2-Arachidonyl Glycerol Is Mediated through Peroxisome Proliferator-Activated Receptor γ Independently of Cannabinoid Receptors 1 and 2
Rockwell, C. E., Snider, N. T., Thompson, J. T., Heuvel, J. P. V., & Kaminski, N. E. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.019117 · Cited by 176 · see citing works
Inhibition of Fatty-Acid Amide Hydrolase Accelerates Acquisition and Extinction Rates in a Spatial Memory Task
Varvel, S. A., Wise, L. E., Niyuhire, F., Cravatt, B. F., & Lichtman, A. H. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301224 · Cited by 173 · see citing works
The Cerebellum: Synaptic Changes and Fear Conditioning
Sacchetti, B., Scelfo, B., & Strata, P. (2005) · The Neuroscientist · doi:10.1177/1073858405276428 · Cited by 170 · see citing works
Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections
Martin, W. J., Coffin, P. O., Attias, E., Balinsky, M., Tsou, K., & Walker, J. M. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01368-7 · Cited by 164 · see citing works
Dorsal hippocampus and classical fear conditioning to tone and context in rats: Effects of local NMDA‐receptor blockade and stimulation
Bast, T., Zhang, W., & Feldon, J. (2003) · Hippocampus · doi:10.1002/hipo.10115 · Cited by 164 · see citing works
Conditioned fear to context is associated with increased Fos expression in the caudal ventrolateral region of the midbrain periaqueductal gray.
Carrive, P., Leung, P., Harris, J. A., & Paxinos, G. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)83047-3 · Cited by 156 · see citing works
WIN 55212-2 impairs contextual fear conditioning through the activation of CB1 cannabinoid receptors
Pamplona, F. A., & Takahashi, R. N. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.026 · Cited by 141 · see citing works
Amygdalar Lateralization in Fear Conditioning: Evidence for Greater Involvement of the Right Amygdala.
Baker, K. B., & Kim, J. J. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.1.15 · Cited by 140 · see citing works
Lesions of the amygdala block conditional hypoalgesia on the tail flick test
Helmstetter, F. J., & Bellgowan, P. S. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91669-j · Cited by 139 · see citing works
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats
Finn, D. P., Jhaveri, M. D., Beckett, S. R. G., Roe, C. H., Kendall, D. A., Marsden, C. A., & Chapman, V. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00235-1 · Cited by 136 · see citing works
Self-citation
CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice
Cannich, A., Wotjak, C. T., Kamprath, K., Hermann, H., Lutz, B., & Marsicano, G. (2004) · Learning & Memory · doi:10.1101/lm.77904 · Cited by 130 · see citing works
Contribution of the amygdala to learning and performance of conditional fear.
Helmstetter, F. J. (1992) · Physiology and Behavior · doi:10.1016/0031-9384(92)90320-2 · Cited by 123 · see citing works
Analgesia produced by lidocaine microinjection into the dentate gyms
McKenna, J. E., & Melzack, R. (1992) · Pain · doi:10.1016/0304-3959(92)90195-h · Cited by 114 · see citing works
Blocking NMDA Receptors in the Hippocampal Dentate Gyrus with AP5 Produces Analgesia in the Formalin Pain Test
McKenna, J. E., & Melzack, R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7777 · Cited by 113 · see citing works
Lesions of the cerebellar vermis and cerebellar hemispheres: Effects on heart rate conditioning in rats.
Supple, W. F., & Leaton, R. N. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.6.934 · Cited by 111 · see citing works
Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity
Strangman, N. M., Patrick, S. L., Hohmann, A. G., Tsou, K., & Walker, J. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01031-2 · Cited by 109 · see citing works
Cannabinoids and PPARα signalling
Sun, Y., Alexander, S. P. H., Kendall, D. A., & Bennett, A. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341095 · Cited by 109 · see citing works
Optimal scoring strategies and weights for the formalin test in rats
Watson, S. G., Sufka, K. J., & Coderre, T. J. (1997) · Pain · doi:10.1016/s0304-3959(96)03299-x · Cited by 108 · see citing works
Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle
Lin, H.-C., Mao, S.-C., & Gean, P.-W. (2006) · Learning & Memory · doi:10.1101/lm.217006 · Cited by 107 · cited 1× · see citing works
“Moreover, the endocannabinoid system in the amygdala has been implicated both in pain modulation (Martin et al., 1999, Manning et al., 2003) and fear conditioning (Marsicano et al., 2002; Cannich et al., 2004; Lin et al., 2006).”
Background
Stress-induced hypoalgesia and defensive freezing are attenuated by application of diazepam to the amygdala
Helmstetter, F. J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90487-e · Cited by 105 · see citing works
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: Sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla
Suplita, R. L., Farthing, J. N., Gutierrez, T., & Hohmann, A. G. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.07.007 · Cited by 104 · see citing works
Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve
Costa, B., Trovato, A. E., Colleoni, M., Giagnoni, G., Zarini, E., & Croci, T. (2005) · Pain · doi:10.1016/j.pain.2005.03.043 · Cited by 104 · see citing works
Behaviorally active doses of the CB1 receptor antagonist SR 141716A increase brain serotonin and dopamine levels and turnover
Darmani, N. A., Janoyan, J. J., Kumar, N. N., et al. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00150-3 · Cited by 99 · see citing works
Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid phenylamide (CP-272871) for the CB1 cannabinoid receptor
Meschler, J. P., Kraichely, D. M., Wilken, G. H., & Howlett, A. C. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00447-0 · Cited by 97 · see citing works
The rodent amygdala contributes to the production of cannabinoid-induced antinociception
Manning, B. H., Martin, W. J., & Meng, I. D. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00356-7 · Cited by 94 · see citing works
Lesions of the cerebellar vermis and cerebellar hemispheres: Effects on heart rate conditioning in rats.
Supple, W. F., & Leaton, R. N. (1990) · Behavioral Neuroscience · doi:10.1037/0735-7044.104.6.934 · Cited by 93 · see citing works
Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain
Kathmann, M., Bauer, U. S., Schlicker, E., et al. (1999) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005377 · Cited by 89 · see citing works
Effects of naltrexone on learning and performance of conditional fear-induced freezing and opioid analgesia
Helmstetter, F. J., & Fanselow, M. S. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90380-5 · Cited by 89 · see citing works
Conditioned dopamine release: Dependence uponN-methyl-d-aspartate receptors
Saulskaya, N. B., & Marsden, C. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00007-6 · Cited by 87 · see citing works
Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia
Connell, K., Bolton, N., Olsen, D., Piomelli, D., & Hohmann, A. G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.008 · Cited by 76 · see citing works
Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain
Finn, D. P., Beckett, S. R. G., Roe, C. H., Madjd, A., Fone, K. C. F., Kendall, D. A., Marsden, C. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03177.x · Cited by 76 · see citing works
Self-citation
PPAR-γ: A nuclear receptor with affinity for cannabinoids
BURSTEIN, S. H. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.039 · Cited by 75 · see citing works
Formalin-induced nociception activates a monoaminergic descending inhibitory system
Omote, K., Kawamata, T., Kawamata, M., & Namiki, A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01086-5 · Cited by 74 · see citing works
The cannabinoid CB1 receptor antagonist SR141716A increases norepinephrine outflow in the rat anterior hypothalamus
Tzavara, E. T., Perry, K. W., Rodriguez, D. E., Bymaster, F. P., & Nomikos, G. G. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01228-6 · Cited by 71 · see citing works
Differential effects of acute cannabinoid drug treatment, mediated by CB 1 receptors, on the in vivo activity of tyrosine and tryptophan hydroxylase in the rat brain
Moranta, D., Esteban, S., & Garc�a-Sevilla, J. A. (2004) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-004-0921-x · Cited by 70 · see citing works
Effects of dopaminergic agents on carrageenan hyperalgesia after intrathecal administration to rats
Gao, X. M., Zhang, Y., & Wu, G.-C. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00930-x · Cited by 70 · see citing works
Modulation of Fear and Anxiety by the Endogenous Cannabinoid System
Chhatwal, J. P., & Ressler, K. J. (2007) · CNS Spectrums · doi:10.1017/s1092852900020939 · Cited by 70 · see citing works
Evidence for differential modulation of conditioned aversion and fear‐conditioned analgesia by CB <sub>1</sub> receptors
Finn, D. P., Beckett, S. R. G., Richardson, D., Kendall, D. A., Marsden, C. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03509.x · Cited by 66 · see citing works
Self-citation
In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids
Roche, M., Diamond, M., Kelly, J. P., & Finn, D. P. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.08.001 · Cited by 65 · see citing works
Self-citation
Mnemonic functions of dorsal striatum and hippocampus in aversive conditioning
White, N. M., & Salinas, J. A. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00402-3 · Cited by 65 · see citing works
The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice
Mikics, É., Dombi, T., Barsvári, B., Varga, B., Ledent, C., Freund, T., & Haller, J. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200605000-00003 · Cited by 61 · see citing works
An automated direct‐injection HPLC‐method for the electrochemical/fluorimetric quantitation of monoamines and related compounds optimized for the screening of large numbers of animals
Seyfried, C. A., Adam, G., & Greve, T. R. (1986) · Biomedical Chromatography · doi:10.1002/bmc.1130010206 · Cited by 54 · see citing works
The Dorsal Raphe Nucleus as a Site of Action of the Antinociceptive and Behavioral Effects of the α4 Nicotinic Receptor Agonist Epibatidine
Cucchiaro, G., Chaijale, N., & Commons, K. G. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.079368 · Cited by 44 · see citing works
CB1 RECEPTOR ACTIVATION IN THE BASOLATERAL AMYGDALA PRODUCES ANTINOCICEPTION IN ANIMAL MODELS OF ACUTE AND TONIC NOCICEPTION
Hasanein, P., Parviz, M., Keshavarz, M., & Javanmardi, K. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04592.x · Cited by 43 · see citing works
Serotonergic mechanisms in the basolateral amygdala differentially regulate the conditioned and unconditioned fear organized in the periaqueductal gray
Martinez, R. C. R., de Oliveira, A. R., & Brandão, M. L. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.02.015 · Cited by 42 · see citing works
Behavioral, central monoaminergic and hypothalamo–pituitary–adrenal axis correlates of fear-conditioned analgesia in rats
Finn, D. P., Jhaveri, M. D., Beckett, S. R. G., Madjd, A., Kendall, D. A., Marsden, C. A., & Chapman, V. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.063 · Cited by 40 · see citing works
Self-citation
Serotoninergic projections from the dorsal raphe nucleus to the nucleus submedius in the rat and cat
Matsuzaki, S., Takada, M., Li, Y.-Q., Tokuno, H., & Mizuno, N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90509-e · Cited by 36 · see citing works
The specificity of Sushi peptides for endotoxin and anionic phospholipids: potential application of POPG as an adjuvant for anti-LPS strategies
Sun, M., Li, P., Ho, B., et al. (2006) · Biochemical Society Transactions · doi:10.1042/bst20060270 · Cited by 35 · see citing works
Biochemical and behavioral anxiolytic-like effects of R (+)HA-966 at the level of the ventral tegmental area in rats
Morrow, B. A., Elsworth, J. D., Zito, C. R., et al. (1999) · Psychopharmacology · doi:10.1007/s002130050941 · Cited by 25 · see citing works
Cannabinoids as Analgesic Agents: Evidence from In Vivo Studies
Finn, D. P., & Chapman, V. (2004) · Current Neuropharmacology · doi:10.2174/1570159043476918 · Cited by 20 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Amygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751 · see citing works
Neural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works
Amygdala FAAH and anandamide: mediating protection and recovery from stress
Gunduz-Cinar, O., Hill, M. N., McEwen, B. S., & Holmes, A. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.08.008 · Cited by 229 · see citing works
Cannabinoid facilitation of fear extinction memory recall in humans
Rabinak, C. A., Angstadt, M., Sripada, C. S., Abelson, J. L., Liberzon, I., Milad, M. R., & Phan, K. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.063 · Cited by 163 · see citing works
Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex
Tan, H., Lauzon, N. M., Bishop, S. F., Chi, N., Bechard, M., & Laviolette, S. R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4718-10.2011 · Cited by 92 · see citing works
Integrated cannabinoid CB1 receptor transmission within the amygdala–prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding
Tan, H., Lauzon, N. M., Bishop, S. F., Bechard, M. A., & Laviolette, S. R. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp210 · Cited by 81 · see citing works
Endocannabinoid signaling in the amygdala: anatomy, synaptic signaling, behavior, and adaptations to stress
Ramikie, T. S., & Patel, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.037 · Cited by 62 · see citing works
Tempering aversive/traumatic memories with cannabinoids: A review of evidence from animal and human studies
Lisboa, S. F., Vila-Verde, C., Rosa, J., Uliana, D. L., Stern, C. A. J., Bertoglio, L. J., Resstel, L. B., & Guimaraes, F. S. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5127-x · Cited by 54 · see citing works

Dysfunction of Ca2+/CaM kinase IIα cascades in the amygdala in post-traumatic stress disorder
Shi (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000294 · Cited by 17 · see citing works
Repeated restraint stress increases basolateral amygdala neuronal activity in an age-dependent manner
Zhang, W., & Rosenkranz, J. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.051 · Cited by 77 · see citing works
Fear, Anxiety, and the Amygdala
Sah, P. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.013 · Cited by 137 · see citing works
Effects of lesions in different nuclei of the amygdala on conditioned taste aversion
Molero‐Chamizo, A., & Urbina, G. N. R. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-5078-1 · Cited by 13 · see citing works
Does the basolateral amygdala store memories for emotional events?
Vazdarjanova, A. I. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01599-x · Cited by 25 · see citing works

Authors: Roche, M., O'Connor, E., Diskin, C., & Finn, D. P.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
ORCID: Roche, Michelle
Diskin, Catherine
Finn, David P.
Venue: European Journal of Neuroscience
Publisher: Wiley
Published: 2007-10-26
Volume: 26
Issue: 9
Pages: 2643-2653
ISSN: 0953-816X (ISSN-L)
1460-9568
DOI: 10.1111/j.1460-9568.2007.05861.x
OpenAlex: W1500759439
Cited by: 83
References: 76
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 10
FWCI: 3.10
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: European Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National University of Ireland
Health Research Board
Science Foundation Ireland
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords: CB1 receptor antagonism, SR141716A, basolateral amygdala, fear conditioning, formalin-induced nociception, fear extinction, endocannabinoid system, monoamines, dopamine, serotonin, homovanillic acid, 5-hydroxyindoleacetic acid, hippocampus, periaqueductal gray
MeSH terms: Rimonabant, Amygdala, Analgesia, Analgesics, Animals, Cerebellum, Conditioning, Psychological, Dopamine, Electric Stimulation, Fear, Functional Laterality, Male, Synaptic Transmission, Pain, Pain Measurement, Periaqueductal Gray, Piperidines, Pyrazoles, Serotonin, Vocalization, Animal, Receptor, Cannabinoid, CB1, Rats, Cannabinoid Receptor Modulators

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The effect of CB1 receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks