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Cited by 96Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Repeated morphine treatment alters polysialylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and cell proliferation in the adult rat hippocampus

Kahn, Laëtitia, Alonso, Gérard, Normand, Elisabeth, Manzoni, Olivier J.·2005·European Journal of Neuroscience
DOI 10.1111/j.1460-9568.2005.03883.x
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Abstract

Altered synaptic transmission and plasticity in brain areas involved in reward and learning are thought to underlie the long‐lasting effects of addictive drugs. In support of this idea, opiates reduce neurogenesis [A.J. Eisch et al. (2000) Proceedings of the National Academy of Sciences USA, 97, 7579–7584] and enhance long‐term potentiation in adult rodent hippocampus [J.M. Harrison et al. (2002) Journal of Neurophysiology, 87, 2464–2470], a key structure of learning and memory processes. Here we studied how repeated morphine treatment and withdrawal affect cell proliferation and neuronal phenotypes in the dentate gyrus‐CA3 region of the adult rat hippocampus. Our data showed a strong reduction of cellular proliferation in morphine‐dependent animals (54% of control) that was followed by a rebound increase after 1 week withdrawal and a return to normal after 2 weeks withdrawal. Morphine dependence was also associated with a drastic reduction in the expression levels of the polysialylated form of neural cell adhesion molecule (68% of control), an adhesion molecule expressed by newly generated neurons and involved in cell migration and structural plasticity. Polysialylated neural cell adhesion molecule levels quickly returned to normal following withdrawal. In morphine‐dependent rats, we found a significant increase of glutamate decarboxylase‐67 mRNA transcription (170% of control) in dentate gyrus granular cells which was followed by a marked rebound decrease after 1 week withdrawal and a return to normal after 4 weeks withdrawal. Together, the results show, for the first time, that, in addition to reducing cell proliferation and neurogenesis, chronic exposure to morphine dramatically alters neuronal phenotypes in the dentate gyrus‐CA3 region of the adult rat hippocampus.

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Metadata

Authors
Kahn, L., Alonso, G., Normand, E., & Manzoni, O. J.
Affiliations
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
ORCID
Manzoni, Olivier J.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2005-01
Volume
21
Issue
2
Pages
493-500
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/j.1460-9568.2005.03883.x
OpenAlex
W2133026993
Cited by
96
References
1
Citations by year
2025: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2019: 2 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 2 · 2012: 8
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 18 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
morphine, opioid use disorder, morphine withdrawal, PSA-NCAM, GAD67, cell proliferation, neurogenesis, hippocampus, neuronal phenotype, synaptic plasticity, addiction
MeSH terms
Animals, Bromodeoxyuridine, Cell Count, Drug Administration Schedule, Gene Expression Regulation, Glutamate Decarboxylase, Hippocampus, Isoenzymes, Male, Morphine, Narcotics, RNA, Messenger, Sialic Acids, Substance Withdrawal Syndrome, Time Factors, Rats, Sprague-Dawley, In Situ Hybridization, Neural Cell Adhesion Molecule L1, Cell Proliferation, Rats

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