The DOI matches its Crossref record; 85 of the 87 references it cites were found in a registry or an index.
Smoking and structural brain deficits: a volumetric MR investigation
Abstract
Growing evidence from animal studies indicates brain‐damaging properties of nicotine exposure. Investigations in humans found a wide range of functional cerebral effects of nicotine and cigarette smoking, but studies focusing on brain damage are sparse. In 22 smokers and 23 never‐smokers possible differences of the cerebral structures were investigated using magnetic resonance imaging and voxel‐based morphometry. Significantly smaller grey matter volume and lower grey matter density (P = 0.05, corrected) were observed in the frontal regions (anterior cingulate, prefrontal and orbitofrontal cortex), the occipital lobe and the temporal lobe including parahippocampal gyrus, in smokers than in never‐smokers. Group differences of either grey matter volume or grey matter density were also found in the thalamus, cerebellum and substantia nigra, among other regions. Smokers did not show greater volumes than never‐smokers in any cerebral region. Magnitude of lifetime exposure to tobacco smoke (pack‐years) was inversely correlated with volume of frontal and temporal lobes and cerebellum (P = 0.001, uncorrected). The data indicate structural deficits of several cortical and subcortical regions in smokers relative to never‐smokers. The topographic profile of the group differences show some similarities to brain networks known to mediate drug reinforcement, attention and working memory processing. The present findings may explain in part the frequently reported cognitive dysfunctions in chronic cigarette consumers.
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“Heavy nicotine use in the form of smoking tobacco has been linked to neuropathy (Brody, 2006), often manifesting as prefrontal gray matter atrophy (Gallinat et al., 2006; Zhang et al., 2011).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Gallinat et al., 2006
Citations
Cites
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,899
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244
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2 of the 87 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Gallinat J., 2006, Abnormal hippocampal neurochemistry in smokers. Evidence from Proton Magnetic Resonance Spectroscopy 3 Tesla, J. Clin. Psychopharmacol.
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Items 301–330 of 330
Understanding the Roles of Genetic and Environmental Influences on the Neurobiology of Nicotine Use
Prom‐Wormley, E. C., Langi, G. G., Clifford, J. S., & Real, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805373-7.00023-2 · Cited by 1
Krishnan, J. (2022) · JOURNAL OF COMMUNICABLE DISEASES · doi:10.24321/0019.5138.202291
Smoking Related Attention Alteration in Chronic Obstructive Pulmonary Disease-Smoking ComorbidityPreprint
Zeng, F., Hong, W., Zha, R., Li, Y., Liu, Y., Liu, H., Liu, M., Liu, M., Xu, F., Hu, D., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-594226/v1 · Cited by 1
Qiu, T., Xie, F., Zeng, Q., Shen, Z., Du, G., Xu, X., Wang, C., Li, X., Luo, X., Li, K., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-959685/v1 · Cited by 1
Brain MRI correlates of depression and vascular risk: Whitehall Imaging sub-study
Allan, C. (2014) · UCL Discovery (University College London) · Cited by 1
Ätiopathogenetische Beiträge der Bildgebungsforschung
Falkai, P., Schneider, F. W., & Gründer, G. (2007) · Springer eBooks · doi:10.1007/978-3-540-33129-2_6
Imaging Techniques in Neurotoxicology Research and Development
Hantson, P. E., & Duprez, T. P. J. (2009) · Wiley eBooks · doi:10.1002/9780470744307.gat042
Functional imaging of substance abuse
Mahmood, O. M., & Tapert, S. F. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511782091.031
Albrecht, L. M. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-13370
Amygdala Morphometry in Adolescent Marijuana Users
McQueeny, T. M. (2010) · OhioLink ETD Center (Ohio Library and Information Network)
Nikolaidou, M. (2015) · The University of Bath Online Publications Store (The University of Bath)
Santiago, C. (2014) · TSpace (University of Toronto)
Aljondi, R. (2017) · Minerva Access (University of Melbourne)
El-Shinnawy, O., Khedr, E. M., Metwally, M., Hassan, A. E. T., Shaddad, A. M., & Soliman, R. K. (2018) · Egyptian Journal of Bronchology · doi:10.4103/ejb.ejb_28_17
Increased Volumes of Subcortical Regions in Patients with Alcohol Dependence
Yang, Q., Yang, K., Niu, Y., Fan, F., Chen, S., Luo, X., Tan, S., Wang, Z., Tong, J., Yang, F., et al. (2021) · Journal of Neurology and Neurobiology · doi:10.16966/2379-7150.175
Ätiopathogenetische Beiträge der Bildgebungsforschung
Falkai, P., Schneider, F. W., & Gründer, G. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_7
Ätiopathogenetische Beiträge der Bildgebungsforschung in der Psychiatrie
Falkai, P., Schneider, F. W., Gründer, G., & Kambeitz, J. P. (2017) · Springer eBooks · doi:10.1007/978-3-642-45028-0_7-2
Gallinat, J. (2009) · Springer eBooks · doi:10.1007/978-3-540-29676-8_3276
Self-citationÄtiopathogenetische Beiträge der Bildgebungsforschung in der Psychiatrie
Falkai, P., Schneider, F. W., Gründer, G., & Kambeitz, J. P. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_7-1
Eken, A., ÇALIŞKAN, Ş., ÇİVİLİBAL, S., & Tosun, P. D. (2020) · DergiPark (Istanbul University)
Cognitive impairment in arterial hypertension in Pakistan
Anwar, M. (2022) · Futurity Medicine. · doi:10.57125/fem.2022.12.30.03
Youdin, R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780197575024.003.0005
Shin, S., Kim, K., Kim, J., Nam, H., Seok, J. W., & Pak, K. (2024) · medRxiv · doi:10.1101/2024.04.29.24306507
Zhang, Z., Wang, Z., Zou, J., Zhang, L., Ning, J., Zhang, X., Heng, L., Zhang, C., Liang, Y., & Zhang, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4724629/v1
Cao, S., Zeng, Y., Chen, M., Ouyang, W., & Ding, Z. (2025) · Anesthesiology and Perioperative Science · doi:10.1007/s44254-025-00133-2
Jiang, L., Kang, Y., Han, X., Wang, Y., Ding, W., Sun, Y., Zhou, Y. F., Han, H., & Lin, F. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112948
Cui, S., Wang, M., Xu, X., Luo, X., Wei, M., & Dong, G.-H. (2025) · Research Square · doi:10.21203/rs.3.rs-7911047/v1
Qiu, S., Zhang, Z., Guo, J., & Hu, Y. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03427-w
Xu, H., Liu, X., Yang, H., Pan, P., Gu, S.-Y., Li, W.-H., & Wang, S. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1762620
Metadata
- Authors
- Gallinat, J., Meisenzahl, E., Jacobsen, L. K., Kalus, P., Bierbrauer, J., Kienast, T., Witthaus, H., Leopold, K., Seifert, F., Schubert, F., & Staedtgen, M.
- Affiliations
- St. Hedwig-Krankenhaus (DE)
- Ludwig-Maximilians-Universität München (DE)
- Yale University (US)
- Physikalisch-Technische Bundesanstalt (DE)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-09
- Volume
- 24
- Issue
- 6
- Pages
- 1744-1750
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2166367939
- Cited by
- 330
- References
- 87
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 16 · 2020: 17 · 2019: 14 · 2018: 16 · 2017: 23 · 2016: 35 · 2015: 29 · 2014: 24 · 2013: 21 · 2012: 23
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- cigarette smoking, nicotine, brain structure, gray matter volume, gray matter density, frontal lobe, temporal lobe, parahippocampal gyrus, thalamus, cerebellum, substantia nigra, pack-years, cognitive impairment
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Smoking
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