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Cited by 19Neurogenesis and neuroplasticity mechanismsNerve injury and regenerationNeuroscience and Neuropharmacology Research

Differential effects of NT‐4, NGF and BDNF on development of neurochemical architecture and cell size regulation in rat visual cortex during the critical period

Engelhardt, Maren, Di Cristo, Graziella, Berardi, Nicoletta, Maffei, Lamberto, Wahle, Petra·2007·European Journal of Neuroscience
DOI 10.1111/j.1460-9568.2006.05301.x
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Abstract

Development of inhibition is a crucial determinant of the time course of visual cortical plasticity. BDNF strongly affects interneuron development and the onset and closure of the critical period for ocular dominance plasticity. Less is known on the effects of NT‐4 despite a clear involvement in ocular dominance plasticity. We have investigated the effects of NT‐4 on interneuron development by supplying NT‐4 with osmotic minipumps during two time windows overlapping the onset (P12–20) and the peak (P20–28) of the critical period. We assessed the expression of interneuronal markers and soma size maturation either after the end of the infusion periods or at the end of the critical period (P45). We found that NT‐4 was very effective in regulating interneuron development. NPY, SOM and PARV neuron somata grew faster during both infusion periods whereas CR neurons only responded during the early infusion period. The effects of soma size elicited during the earlier infusion period were still present at P45. In PARV neurons, NT‐4 caused a long‐lasting stabilization of CB and NPY expression. Furthermore, NT‐4 accelerated the expression of GAD‐65 mRNA in a subset of non‐PARV neurons of layer V, which normally up‐regulate GAD‐65 towards the end of the critical period. Most of these effects were shared by NT‐4 and BDNF. Some were unexpectedly also shared by NGF, which promoted growth of layer V PARV neurons, stabilized the CB expression and accelerated the GAD‐65 expression. The results suggest that neurotrophins act on critical period plasticity by strengthening inhibition.

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  • BDNF regulates neuron survival, plasticity, and synaptic function, plays an integral role in differentiation during development, is affected by stress, and is associated with major depression and suicidal behavior.

    “Brain-derived neurotrophic factor (BDNF) regulates neuron survival, plasticity, and synaptic function (169-174), plays an integral role in differentiation during development (175, 176), is affected by stress (177), and is associated with major depression and suicidal behavior (178).”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [176]

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Authors
Engelhardt, M., Di Cristo, G., Berardi, N., Maffei, L., & Wahle, P.
Affiliations
  • Ruhr University Bochum (DE)
  • National Research Council (IT)
Corresponding author
Wahle, Petra
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2007-01
Volume
25
Issue
2
Pages
529-540
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1111/j.1460-9568.2006.05301.x
OpenAlex
W2048413577
Cited by
19
References
54
Citations by year
2026: 1 · 2025: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 1
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 23 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neurotrophin-4, nerve growth factor, brain-derived neurotrophic factor, neurotrophins, visual cortex, critical period, ocular dominance plasticity, interneuron development, somatostatin neurons, parvalbumin neurons, calbindin, neuropeptide Y, cortical inhibition, cell size control, layer V
MeSH terms
Animals, Cell Count, Critical Period, Psychological, Nerve Growth Factors, Nerve Tissue Proteins, RNA, Messenger, Visual Cortex, Gene Expression Regulation, Developmental, Rats, Long-Evans, Cell Size, Cell Enlargement, Rats

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