BDNF and epilepsy: too much of a good thing?
Abstract
Various studies have shown that brain-derived neurotrophic factor (BDNF) increases neuronal excitability and is localized and upregulated in areas implicated in epileptogenesis. Seizure activity increases the expression of BDNF mRNA and protein, and recent studies have shown that interfering with BDNF signal transduction inhibits the development of the epileptic state in vivo. These results suggest that BDNF contributes to epileptogenesis. Further analysis of the cellular and molecular mechanisms by which BDNF influences excitability and connectivity in adult brain could provide novel concepts and targets for anticonvulsant or anti-epileptogenic therapy.
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Overexpression of BDNF may contribute to epilepsy-induced cortical network deregulation by increasing plasticity and dendritic branching signaling, causing an overexcitement state of glutamatergic neurons and reducing seizure threshold.
“Overexpression of BDNF may also contribute to the epilepsy-induced cortical network deregulation by increasing even further the plasticity and dendritic branching signaling and causing an overexcitement state of glutamatergic neurons, thus reducing seizure threshold [185].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [185]
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- Authors
- Binder, D. K., Croll, S. D., Gall, C. M., & Scharfman, H. E.
- Affiliations
- University of California, San Francisco (US)
- Regeneron (United States) (US)
- University of California, Irvine (US)
- Helen Hayes Hospital (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 24
- Issue
- 1
- Pages
- 47-53
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2025978099
- Cited by
- 454
- References
- 76
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 14 · 2023: 29 · 2022: 19 · 2021: 22 · 2020: 24 · 2019: 17 · 2018: 16 · 2017: 8 · 2016: 17 · 2015: 20 · 2014: 17 · 2013: 19 · 2012: 23
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, epilepsy, epileptogenesis, neuronal excitability, BDNF signaling, anticonvulsant therapy, seizure activity, neuronal connectivity
- MeSH terms
- Animals, Epilepsy, Hippocampus, Humans, Kindling, Neurologic, RNA, Messenger, Signal Transduction, Up-Regulation, Pyramidal Cells, Brain-Derived Neurotrophic Factor, Receptor, trkB
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