The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The effects of running and of inhibiting adult neurogenesis on learning and memory in rats.
Abstract
The presence of ongoing adult neurogenesis within the highly plastic hippocampal circuitry poses questions as to the relevance of new neurons to learning and memory. Correlational and causal evidence suggests that some, but not all, hippocampal tasks involve the new neurons. The evidence with regard to spatial learning in the water maze, one of the most commonly used hippocampal tasks, is contradictory. In this study we examined the effects of irradiation-induced reduction in neurogenesis on spatial learning and another standard hippocampal task, contextual fear conditioning, in rats that experienced normal cage conditions or voluntary running. The results indicate that reduced neurogenesis had little effect on spatial learning but severely impaired contextual fear conditioning. It was suggested that compensatory mechanisms within the hippocampus may have contributed selectively to sparing of spatial function. Performance on the fear conditioning task was weakly related to enhanced neurogenesis or running. The results improve our understanding of the functional role of adult neurogenesis in behaving animals.
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“For example, inhibiting the rate of cell proliferation in mice was sufficient to impair pattern separation (Deng et al., 2010) and block AE-induced improvements in spatial (Clark et al., 2009) and contextual (Wojtowicz et al., 2008) memory performance, but only in conditions in which the task required fine spatial discriminations (i.e., where pattern separation was necessary; Creer et al., 2010).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Wojtowicz et al., 2008
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Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation
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Stress, hippocampal neurogenesis and cognition: functional correlations
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“…after hippocampal lesions, performance on standard spatial water maze training and probe trials is consistently spared in mice and rats that lack adult neurogenesis (Snyder et al., 2005; Wojtowicz et al., 2008; Arruda-Carvalho et al., 2011; Ben Abdallah et al., 2013; see also Snyder et al., 2016).”
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Greer, T. L., Ring, K. M., Warden, D., Grannemann, B. D., Church, T. S., Somoza, E. C., Blair, S. N., Szapocznik, J., Stoutenberg, M., Rethorst, C. D., et al. (2012) · PubMed · Cited by 17
Neuroregeneration: Regulation in Neurodegenerative Diseases and Aging
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“Prior work indicated two consecutive days of 10 Gy irradiation leads to a complete ablation of neurogenesis in the dorsal hippocampus, with 50 percent suppression in the ventral hippocampus (Wojtowicz et al. 2008; Noonan et al. 2010).”
BackgroundKent, B. A., Oomen, C. A., Bekinschtein, P., Bussey, T. J., & Saksida, L. M. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.06.009 · Cited by 19
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“1999a) whereas experimental ablation of neurogenesis, either by administration of methylazoxymethanol acetate or irradiation, impairs performance (Madsen et al. 2003; Shors et al. 2001, 2002; Snyder et al. 2005; Winocur et al. 2006; Wojtowicz et al. 2008).”
BackgroundCyclin-Dependent Kinase Inhibitor 1a (p21) Modulates Response to Cocaine and Motivated Behaviors
Scholpa, N. E., Briggs, S. B., Wagner, J. J., & Cummings, B. S. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.230888 · Cited by 14
“Multiple studies suggest a correlation between adult neurogenesis and learning capability (Shors et al., 2001, 2002; Raber et al., 2004; Winocur et al., 2006; Wojtowicz et al., 2008; Snyder et al., 2009a,b; Deng et al., 2010; Cameron andGlover, 2015), such as that necessary for successful CPP and CPA.”
BackgroundStress and binge drinking: A toxic combination for the teenage brain
Goldstein, A., Déry, N., Pilgrim, M., Ioan, M., & Becker, S. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.035 · Cited by 15
“Knockdown of neurogenesis results in selective impairments on a wide range of high interference memory tasks, whether the interference arises from overlapping stimuli, time delay between learning and retrieval, context effects, or reversal of previously learned responses (Becker, 2005; Luu et al., 2012; Winocur et al.…”
Eszopiclone and fluoxetine enhance the survival of newborn neurons in the adult rat hippocampus
Su, X., Li, X., Banasr, M., & Duman, R. S. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990629 · Cited by 14
“chronic mild stress) on neurogenesis (Surget, 2008; Wojtowicz et al. 2008).”
BackgroundRole of Neuronal Ras Activity in Adult Hippocampal Neurogenesis and Cognition
Manns, M., Leske, O., Gottfried, S., Bichler, Z., Lafenêtre, P., Wahle, P., & Heumann, R. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00018 · Cited by 13
“In general, impairments emerge with increasing complexity of behavioral tasks (Wojtowicz et al., 2008; Clelland et al., 2009; Aimone et al., 2010). the transgenic activation of H-Ras in differentiated neurons specifically attenuates mitotic activity of the early type-2a cells (Kronenberg et al.,…”
BackgroundEnhanced post-ischemic neurogenesis in aging rats
Tan (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00163 · Cited by 13
“Emerging evidence indicates that memory tasks involving detection and processing of context are most sensitive to changes in neurogenesis and should be good indicators of deteriorating memory performance at old age (Wojtowicz et al., 2008).”
BackgroundThe effects of two forms of physical activity on eyeblink classical conditioning
Green, J. T., Chess, A. C., Burns, M., Schachinger, K. M., & Thanellou, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.016 · Cited by 12
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“…showing that new neurons are not necessary for all aspects of hippocampusdependent learning (Jaholkowski et al. 2009; Leuner et al. 2006; Winocur et al. 2006; Wojtowicz et al. 2008) and supports that synRas mice did not suffer from general learning deficits caused by structural cortical changes.”
BackgroundResultAdult Neurogenesis and Dendritic Remodeling in Hippocampal Plasticity: Which One is more Important?
Yau, S., & So, K. (2014) · Cell Transplantation · doi:10.3727/096368914x678283 · Cited by 11
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“On the other hand, our results are in agreement with Burghardt et al. (2004) who did not fi nd signifi cant effects of either 4 or 8 weeks of wheel running on aversive context memory in rats, and with Wojtowicz et al. (2008), who also reported no Duman CH, Schlesinger L, Russell DS, Duman RS. 2008.”
ResultHersman, S., Barrera, V. R., & Fanselow, M. S. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00182 · Cited by 9
“The procedure refers to how the experiment is constructed (e.g., operational definitions).”
BackgroundMethodAdult neurogenesis mediates forgetting of multiple types of memory in the ratPreprint
Scott, G. A., Terstege, D. J., Roebuck, A. J., Gorzo, K. A., Vu, A. P., Howland, J. G., & Epp, J. R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.22.436536 · Cited by 9
Chang, W.-L., & Hen, R. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-62983-9_10 · Cited by 8
The Contribution of Adult Hippocampal Neurogenesis to the Progression of Psychiatric Disorders
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Pištíková, A., Brožka, H., & Stuchlı́k, A. (2017) · Physiological Research · doi:10.33549/physiolres.933627 · Cited by 8
“However, many other studies have failed to find an effect of adult neurogenesis in hippocampal-dependent tasks (Saxe et al. 2006, Hernández-Rabaza et al. 2009, Wojtowicz et al. 2008, Groves et al. 2013, Martinez-Canabal et al. 2013).”
BackgroundThe Impact of Ethologically Relevant Stressors on Adult Mammalian Neurogenesis
Jorgensen, C., Taylor, J. A., & Barton, T. (2019) · Brain Sciences · doi:10.3390/brainsci9070158 · Cited by 7
“Other studies utilized rats well into adulthood at 70 days or more [72,77,136], and still others report subjects as being adult, but do not specify age [52,61,78,90,137].”
BackgroundCominski, T. P., Ansonoff, M., Turchin, C., & Pintar, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.039 · Cited by 6
“In contrast, however, other studies suggest that DG neurogenesis is not required for spatial learning (Wojtowicz et al., 2008; Hernandez-Rabaza et al., 2009; Groves et al., 2013).”
Bulin, S. E., Simmons, S. J., Richardson, D. R., Latchney, S. E., Deutsch, H. M., Yun, S., & Eisch, A. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112448 · Cited by 6
Adult Neurogenesis in the Hippocampus: Lessons from Natural Populations
Wojtowicz, J. M. (2011) · Springer eBooks · doi:10.1007/978-4-431-53933-9_10 · Cited by 3
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Stranahan, A. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.06.026 · Cited by 3
“Indeed, ablation experiments suggest that in rats, adult neurogenesis is not necessary for effective spatial learning (Shors et al., 2002; Wojtowicz et al., 2008), although new neurons do express immediate early genes preferentially relative to pre-existing neurons following water maze training (Snyder et al.”
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Ammassari‐Teule, M., Mariucci, G., & Ambrosini, M. V. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_13
“Indeed, data showing that motor activity produces hippocampal neurogenesis (Farmer et al., 2004; Naylor et al., 2005; Uda et al., 2006), which is beneficial for both memory ( Wojtowicz et al., 2008 ) and depression (Sahay et al., 2007), do not help in identifying the primary mechanism responsible for enhanced Hsp72 ex…”
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Behavior and cytogenesis following irradiation or isoflurane exposure to the developing brain
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The Role of the Hippocampus in Detecting the Novelty of Impressions: A Literature Review
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Miura, H., Furukawa, T., Sato, C., Monden, A., Nunomura, T., Umamichi, K., Hatakenaka, K., Yamazaki, R., Yamaguchi, M., Koeda, S., et al. (2025) · Radiation Research · doi:10.1667/rade-25-00055.1
Additional file 1 of Adult neurogenesis mediates forgetting of multiple types of memory in the rat
Scott, G. A., Terstege, D. J., Roebuck, A. J., Gorzo, K. A., Vu, A. P., Howland, J. G., & Epp, J. R. (2021) · Figshare · doi:10.6084/m9.figshare.14853185
Serrano, C. (2020) · theses.fr (ABES) · doi:10.70675/78f0fd9ez9539z4840z8e1dz06c913388dc3
Metadata
- Authors
- Wojtowicz, J. M., Askew, M. L., & Winocur, G.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Wojtowicz, J. Martin
- ORCID
- Winocur, Gordon
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-03
- Volume
- 27
- Issue
- 6
- Pages
- 1494-1502
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2169145097
- Cited by
- 158
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 9 · 2016: 16 · 2015: 15 · 2014: 12 · 2013: 10 · 2012: 10
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Toronto
- National Institutes of Health
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, voluntary running, hippocampus, spatial learning, contextual fear conditioning, compensatory mechanisms, learning and memory, hippocampal plasticity
- MeSH terms
- Animals, Cell Differentiation, Cobalt Radioisotopes, Fear, Hippocampus, Learning, Male, Memory, Physical Conditioning, Animal, Random Allocation, Rats, Long-Evans, Rats
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