Activation of phasic pontine‐wave generator in the rat: a mechanism for expression of plasticity‐related genes and proteins in the dorsal hippocampus and amygdala
Open accessAbstract
A number of behavioral studies have emphasized the importance of interactions between the pontine-wave (P-wave) generator and the dorsal hippocampus (DH) in two-way active avoidance (TWAA) memory processing; however, the direct involvement of the P-wave generator in the TWAA training trial-induced molecular events in the DH and amygdala has not been systematically evaluated. Here we demonstrate that the TWAA learning training trials activate P-wave generator, and increase phosphorylation of CREB (pCREB) and expression of activity-regulated cytoskeletal-associated (Arc) protein, as well as messenger ribonucleic acid (mRNAs) of Arc, brain-derived nerve growth factor (BDNF) and early growth response-1 (Egr-1) in the DH and amygdala. Selective elimination of P-wave-generating cells abolished P-wave activity and suppressed TWAA learning training trial-induced expression of pCREB and Arc proteins and Arc, BDNF and Egr-1 mRNAs in the DH and amygdala. Following a session of TWAA training, all rats were equal in terms of time spent in wakefulness, slow-wave sleep and rapid eye movement (REM) sleep irrespective of P-wave lesions. The second set of experiments demonstrated that localized cholinergic stimulation of the P-wave generator increased expression of Arc, BDNF and Egr-1 mRNAs in the DH. Together, these findings provide the first direct evidence that activation of P-wave-generating cells is critically involved in the TWAA training trial-induced expression of plasticity-related ge…
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PGO wave density during posttraining REM sleep is correlated with increased activity of plasticity-related immediate early genes and brain-derived neurotrophic factors in the dorsal hippocampus.
“Moreover, PGO wave density during posttraining REM sleep is correlated with increased activity of plasticity-related immediate early genes and brain-derived neurotrophic factors in the dorsal hippocampus.”
From About Sleep's Role in Memory (2013) · cites this paper as [261]
Training on an active avoidance task is followed by a robust increase in PGO wave density for 3-4 h after training, and changes in PGO wave density were also proportional to the improvement in task performance between initial training and post-sleep retest.
“Training on an active avoidance task is followed by a robust increase in PGO wave density for 3-4 h after training, and changes in PGO wave density were also proportional to the improvement in task performance between initial training and post-sleep retest (259, 261, 1225).”
From About Sleep's Role in Memory (2013) · cites this paper as [261]
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“These increases were abolished after selective elimination of the PGO wave generating cells in the brain stem and enhanced after cholinergic stimulation of these cells (261, 1225).”
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- Authors
- Datta, S., Li, G., & Auerbach, S.
- Affiliations
- Boston University (US)
- Corresponding author
- Datta, Subimal
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-03-31
- Volume
- 27
- Issue
- 7
- Pages
- 1876-1892
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2430524
- OpenAlex
- W2045842869
- Cited by
- 99
- References
- 6
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 2 · 2019: 10 · 2018: 1 · 2017: 12 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 6 · 2012: 7
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH 59839, R01MH059839)
- National Institute of Neurological Disorders and Stroke (R29NS034004, NS-34004, R01NS034004)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- two-way active avoidance, hippocampus, amygdala, CREB phosphorylation, Arc protein, brain-derived neurotrophic factor, EGR1, synaptic plasticity, REM sleep, cholinergic stimulation, sleep-dependent memory consolidation, gene expression
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Gene Expression Regulation, Hippocampus, Male, Neuronal Plasticity, Pons, Sleep, REM, Protein Biosynthesis, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, CREB-Binding Protein, Rats
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