Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide

Leptin-regulated endocannabinoids are involved in maintaining food intake

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Novel cannabinoid receptors

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Biochemistry and pharmacology of endovanilloids

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Endocannabinoids control spasticity in a multiple sclerosis model

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The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons.

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Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase

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Cannabinoid CB₁and CB₂Receptors and Fatty Acid Amide Hydrolase Are Specific Markers of Plaque Cell Subtypes in Human Multiple Sclerosis

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The search for the palmitoylethanolamide receptor

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The Palmitoylethanolamide and Oleamide Enigmas: Are These Two Fatty Acid Amides Cannabimimetic?

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Palmitoylethanolamide Increases after Focal Cerebral Ischemia and Potentiates Microglial Cell Motility

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Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats

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Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

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The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking

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Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis

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Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

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Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection

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Activation of the endocannabinoid system as a therapeutic approach in a murine model of multiple sclerosis

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Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury

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Axonal Injury Heralds Virus-Induced Demyelination

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Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation

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Drug Insight: effects mediated by peroxisome proliferator-activated receptor-γ in CNS disorders

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WY14,643, a PPARα Ligand, Has Profound Effects on Immune Responses In Vivo

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Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease

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Microglia produce and hydrolyze palmitoylethanolamide

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Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma β-cells

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Selective Antiepileptic Effects ofN‐Palmitoylethanolamide, a Putative Endocannabinoid

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Intestinal Monoacylglycerol Metabolism

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Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17β‐estradiol

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Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders

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Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin‐granuloma model in rats

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Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones

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Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody

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Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice

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The (endo)cannabinoid system in multiple sclerosis and amyotrophic lateral sclerosis.

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Dexamethasone regulation of interleukin-1-receptors in the hippocampus of Theiler's virus-infected mice: effects on virus-mediated demyelination

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Extensive Injury of Descending Neurons Demonstrated by Retrograde Labeling in a Virus-Induced Murine Model of Chronic Inflammatory Demyelination

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Cannabinoids and the expanded endocannabinoid system in neurological disorders

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Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside

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An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events

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The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies

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Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide—targets for drug development?

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Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide11Abbreviations: AEA, anandamide, arachidonyl ethanolamide; PEA, palmitoylethanolamide, N-(2-hydroxyethyl) hexadecamide; FAAH, fatty acid amide hydrolase; CB, cannabinoid; PMSF, phenylmethylsulfonyl fluoride; MAFP, methyl arachidonyl fluorophosphonate; methAEA, arachidonyl-1′-hydroxy-2′-propylamide; and NSAIDs, nonsteroidal anti-inflammatory drugs.

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Metabolism of the Endocannabinoids Anandamide and 2-Arachidonoyl Glycerol, A Review, with Emphasis on the Pharmacology of Fatty Acid Amide Hydrolase, A Possible Target for the Treatment of Neurodegenerative Diseases and Pain

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Endocannabinoid Metabolic Pathways and Enzymes

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Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity

Petrosino, S., Moriello, A. S., Verde, R., Allarà, M., Imperatore, R., Ligresti, A., Mahmoud, A. M., Peritore, A. F., Iannotti, F. A., & Marzo, V. D. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1671-5 · Cited by 76 · see citing works