The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies
Open accessAbstract
Neurological disorders such as neurodegenerative diseases or traumatic brain injury are associated with cognitive, motor and behavioural changes that influence the quality of life of the patients. Although different therapeutic strategies have been developed and tried until now to decrease the neurological decline, no treatment has been found to cure these pathologies. In the last decades, the implication of the endocannabinoid system in the neurological function has been extensively studied, and the cannabinoids have been tried as a new promising potential treatment. In this study, we aimed to overview the recent available literature regarding in vivo potential of natural and synthetic cannabinoids with underlying mechanisms of action for protecting against cognitive decline and motor impairments. The results of studies on animal models showed that cannabinoids in traumatic brain injury increase neurobehavioral function, working memory performance, and decrease the neurological deficit and ameliorate motor deficit through down-regulation of pro-inflammatory markers, oedema formation and blood–brain barrier permeability, preventing neuronal cell loss and up-regulating the levels of adherence junction proteins. In neurodegenerative diseases, the cannabinoids showed beneficial effects in decreasing the motor disability and disease progression by a complex mechanism targeting more signalling pathways further than classical receptors of the endocannabinoid system. In light of these results, the use of cannabinoids could be beneficial in traumatic brain injuries and multiple sclerosis treatment, especially in those patients who display resistance to conventional treatment.
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Therapies with phytopharmaceuticals with known neuroprotective effects could generate neuroenhancers that may greatly improve cognitive capacity in patients with Alzheimer's disease, reducing the main disadvantages of conventional pharmacology.
“Therapies with phytopharmaceuticals with known neuroprotective effects could generate neuroenhancers that may greatly improve cognitive capacity in patients with AD, reducing the main disadvantages of conventional pharmacology [31].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [31]
Non-pharmacological treatments are frequently chosen as a first-line option to mitigate Alzheimer's disease symptoms and represent the most valid alternative and/or complement to pharmacological treatment.
“The non-pharmacological treatments (NPT) are frequently chosen as a first-line option to mitigate AD symptoms and represent the most valid alternative and/or complement to pharmacological treatment [3,31].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [31]
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Sharifi-Rad, J., Quispe, C., Imran, M., Rauf, A., Nadeem, M., Gondal, T. A., Ahmad, B., Atif, M., Mubarak, M. S., Sytar, O., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3268136 · Cited by 389 · see citing works
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“Therapies with phytopharmaceuticals with known neuroprotective effects could generate neuroenhancers that may greatly improve cognitive capacity in patients with AD, reducing the main disadvantages of conventional pharmacology [31].”
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Self-citation
- Authors
- Calina, D., Buga, A. M., Mitroi, M., Buha, A., Caruntu, C., Scheau, C., Bouyahya, A., El Omari, N., El Menyiy, N., & Docea, A. O.
- Affiliations
- Clinical Pharmacy Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- Biochemistry Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
- University of Medicine and Pharmacy of Craiova (RO)
- Department of Toxicology “Akademik Danilo Soldatović”-Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia
- Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
- Carol Davila University of Medicine and Pharmacy (RO)
- Mohammed V University (MA)
- Laboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, 10100 Rabat, Morocco
- Laboratory of Physiology, Pharmacology & Environmental Health, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, 30000 Fez, Morocco
- Corresponding author
- Docea, Anca Oana
- ORCID
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2020-07-27
- Volume
- 9
- Issue
- 8
- Pages
- 2395
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC7464236
- OpenAlex
- W3043916117
- Cited by
- 65
- References
- 113
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 18 · 2022: 17 · 2021: 17 · 2020: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- cannabinoids, endocannabinoid system, traumatic brain injury, neurodegenerative diseases, multiple sclerosis, cognitive impairment, motor impairment, neuroprotection, neuroinflammation, blood-brain barrier permeability, working memory, neuronal loss, animal models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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