The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Coselection for microbial resistance to metals and antibiotics in freshwater microcosms
Abstract
Summary: Bacterial resistances to diverse metals and antibiotics are often genetically linked, suggesting that exposure to toxic metals may select for strains resistant to antibiotics and vice versa. To test the hypothesis that resistances to metals and antibiotics are coselected for in environmental microbial assemblages, we investigated the frequency of diverse resistances in freshwater microcosms amended with Cd, Ni, ampicillin or tetracycline. We found that all four toxicants significantly increased the frequency of bacterioplankton resistance to multiple, chemically unrelated metals and antibiotics. An ampicillin‐resistant strain of the opportunistic human pathogen Ralstonia mannitolilytica was enriched in microcosms amended with Cd. Frequencies of antibiotic resistance were elevated in microcosms with metal concentrations representative of industry and mining‐impacted environments (0.01–1 mM). Metal but not antibiotic amendments decreased microbial diversity, and a weeklong exposure to high concentrations of ampicillin (0.01–10 mg l −1 ) and tetracycline (0.03–30 mg l −1 ) decreased microbial abundance only slightly, implying a large reservoir of antibiotic resistance in the studied environment. Our results provide first experimental evidence that the exposure of freshwater environments to individual metals and antibiotics selects for multiresistant microorganisms, including opportunistic human pathogens.
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Cites
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., & Buxton, H. T. (2002) · Environmental Science & Technology · doi:10.1021/es011055j · Cited by 7,953
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834 · cited 2×
“While the use of antibiotics in medicine and agriculture clearly stimulates the proliferation of antibiotic resistance (Neu, 1992), heavy metals and other toxicants have also been suggested to play an important role (Summers, 2002).”
BackgroundSampling the Antibiotic Resistome
D'Costa, V. M., McGrann, K. M., Hughes, D. W., & Wright, G. D. (2006) · Science · doi:10.1126/science.1120800 · Cited by 1,594
Cited by
Seiler, C., & Berendonk, T. U. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00399 · Cited by 1,018
Imran, M., Das, K. R., & Naik, M. M. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2018.10.114 · Cited by 597
Zhang, Y., Gu, A. Z., Cen, T., Li, X., He, M., Li, D., & Chen, J. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.01.032 · Cited by 472
Hu, H.-W., Wang, J.-T., Li, J., Shi, X.-Z., Ma, Y.-B., Chen, D., & He, J.-Z. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b03383 · Cited by 312
Heavy Metal Induced Antibiotic Resistance in Bacterium LSJC7
Chen, S., Li, X., Sun, G., Zhang, Y., Su, J., & Ye, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161023390 · Cited by 128
Metadata
- Authors
- Stepanauskas, R., Glenn, T. C., Jagoe, C. H., Tuckfield, R. C., Lindell, A. H., King, C. J., & McArthur, J. V.
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2006-07-10
- Volume
- 8
- Issue
- 9
- Pages
- 1510-1514
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2009710104
- Cited by
- 300
- References
- 3
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stepanauskas, R., Glenn, T. C., Jagoe, C. H., Tuckfield, R. C., Lindell, A. H., King, C. J., & McArthur, J. V. (2006). Coselection for microbial resistance to metals and antibiotics in freshwater microcosms. Environmental Microbiology. https://doi.org/10.1111/j.1462-2920.2006.01091.x
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