The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa
Abstract
Summary: Polymicrobial bronchopulmonary infections in cystic fibrosis (CF) cause progressive lung damage and death. Although the arrival of Pseudomonas aeruginosa often heralds a more rapid rate of pulmonary decline, there is significant inter‐individual variation in the rate of decline, the causes of which remain poorly understood. By coupling culture‐independent methods with ecological analyses, we discovered correlations between bacterial community profiles and clinical disease markers in respiratory tracts of 45 children with CF. Bacterial community complexity was inversely correlated with patient age, presence of P. aeruginosa and antibiotic exposure, and was related to CF genotype. Strikingly, bacterial communities lacking P. aeruginosa were much more similar to each other than were those containing P. aeruginosa , regardless of antibiotic exposure. This suggests that community composition might be a better predictor of disease progression than the presence of P. aeruginosa alone and deserves further study.
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Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
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Self-citationStatistical significance for genomewide studies
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An ecological and evolutionary perspective on human–microbe mutualism and disease
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Cited by
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
Costello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J. M., & Relman, D. A. (2012) · Science · doi:10.1126/science.1224203 · Cited by 1,437
Self-citationDecade-long bacterial community dynamics in cystic fibrosis airways
Zhao, J., Schloss, P. D., Kalikin, L. M., Carmody, L. A., Foster, B. K., Petrosino, J. F., Cavalcoli, J. D., VanDevanter, D. R., Murray, S., Li, J. Z., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120577109 · Cited by 599
Disordered Microbial Communities in the Upper Respiratory Tract of Cigarette Smokers
Charlson, E. S., Chen, J., Custers-Allen, R., Bittinger, K., Li, H., Sinha, R., Hwang, J., Bushman, F. D., & Collman, R. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015216 · Cited by 437
The role of the bacterial microbiome in lung disease
Dickson, R. P., Erb-Downward, J. R., & Huffnagle, G. B. (2013) · Expert Review of Respiratory Medicine · doi:10.1586/ers.13.24 · Cited by 419
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Metadata
- Authors
- Klepac‐Ceraj, V., Lemon, K. P., Martin, T. R., Allgaier, M., Kembel, S. W., Knapp, A. A., Lory, S., Brodie, E. L., Lynch, S. V., Bohannan, B. J. M., Green, J. L., Maurer, B. A., & Kolter, R.
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2010-04-23
- Volume
- 12
- Issue
- 5
- Pages
- 1293-1303
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2163064806
- Cited by
- 218
- References
- 7
- FWCI
- 17.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Klepac‐Ceraj, V., Lemon, K. P., Martin, T. R., Allgaier, M., Kembel, S. W., Knapp, A. A., Lory, S., Brodie, E. L., Lynch, S. V., Bohannan, B. J. M., Green, J. L., Maurer, B. A., & Kolter, R. (2010). Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa. Environmental Microbiology. https://doi.org/10.1111/j.1462-2920.2010.02173.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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