The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Candida albicans proteinases and host/pathogen interactions
Open accessAbstract
Candida infections are common, debilitating and often recurring fungal diseases and a problem of significant clinical importance. Candida albicans, the most virulent of the Candida spp., can cause severe mucosal and life-threatening systemic infections in immunocompromised hosts. Attributes that contribute to C. albicans virulence include adhesion, hyphal formation, phenotypic switching and extracellular hydrolytic enzyme production. The extracellular hydrolytic enzymes, especially the secreted aspartyl proteinases (Saps), are one of few gene products that have been shown to directly contribute to C. albicans pathogenicity. Because C. albicans is able to colonize and infect almost every tissue in the human host, it may be crucial for the fungus to possess a number of similar but independently regulated and functionally distinct secreted proteinases to provide sufficient flexibility in order to survive and promote infection at different niche sites. The aim of this review is to explore the functional roles of the C. albicans proteinases and how they may contribute to the host/pathogen interaction in vivo.
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Transcription regulation and animal diversity
Levine, M., & Tjian, R. (2003) · Nature · doi:10.1038/nature01763 · Cited by 1,309
Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
Naglik, J. R., Challacombe, S. J., & Hube, B. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.3.400-428.2003 · Cited by 1,179
Self-citationAdherence and receptor relationships of Candida albicans
Calderone, R. A., & Braun, P. C. (1991) · Microbiological Reviews · doi:10.1128/mr.55.1.1-20.1991 · Cited by 427
Sundstrom, P. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00206.x · Cited by 336
Murad, A. M. A., D'Enfert, C., Gaillardin, C., Tournu, H., Tekaia, F., Talibi, D., Marechal, D., Marchais, V., Cottin, J., & Brown, A. J. P. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02713.x · Cited by 208 · cited 6×
“For instance, in a murine model of oropharyngeal candidosis, SAP1–6 and SAP9 transcripts were detected continuously throughout the course of infection with SAP5 and SAP9 being most highly expressed (Ripeau et al., 2002), and in a mouse model of gastrointestinal infection SAP4 and SAP6 were constitutively expressed, wi…”
BackgroundInfluentialNaglik, J. R., Rodgers, C. A., Shirlaw, P. J., Dobbie, J. L., Fernandes‐Naglik, L. L., Greenspan, D., Agabian, N., & Challacombe, S. J. (2003) · The Journal of Infectious Diseases · doi:10.1086/376536 · Cited by 206
Self-citationIn Vivo Analysis of Secreted Aspartyl Proteinase Expression in Human Oral Candidiasis
Naglik, J. R., Newport, G., White, T. C., Fernandes-Naglik, L. L., Greenspan, J. S., Greenspan, D., Sweet, S. P., Challacombe, S. J., & Agabian, N. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2482-2490.1999 · Cited by 193
Self-citation
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Our Current Understanding of Fungal Biofilms
Ramage, G., Mowat, E., Jones, B., Williams, C., & Lopez-Ribot, J. (2009) · Critical Reviews in Microbiology · doi:10.3109/10408410903241436 · Cited by 483
Almeida, R. S., Brunke, S., Albrecht, A., Thewes, S., Laue, M., Edwards, J. E., Filler, S. G., & Hube, B. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000217 · Cited by 330
Self-citationHarnessing calcineurin as a novel anti-infective agent against invasive fungal infections.
Steinbach, W. J., Reedy, J. L., Cramer, R. A., Perfect, J. R., & Heitman, J. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1680 · Cited by 313
Metadata
- Authors
- Naglik, J., Albrecht, A., Bader, O., & Hube, B.
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2004-10
- Volume
- 6
- Issue
- 10
- Pages
- 915-926
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2094405531
- Cited by
- 390
- References
- 7
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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