The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Dictyostelium as host model for pathogenesis
Open accessAbstract
The haploid social soil amoeba Dictyostelium discoideum has been established as a host model for several pathogens including Pseudomonas aeruginosa, Cryptococcus neoformans, Mycobacterium spp. and Legionella pneumophila. The research areas presently pursued include (i) the use of Dictyostelium wild-type cells as screening system for virulence of extracellular and intracellular pathogens and their corresponding mutants, (ii) the use of Dictyostelium mutant cells to identify genetic host determinants of susceptibility and resistance to infection and (iii) the use of reporter systems in Dictyostelium cells which allow the dissection of the complex host-pathogen cross-talk. The body of information presented in this review demonstrates that the availability of host cell markers, the knowledge of cell signalling pathways, the completion of the genome sequencing project and the tractability for genetic studies qualifies Dictyostelium for the study of fundamental cellular processes of pathogenesis.
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“Several bacterial pathogens for humans, such as legionella, mycobacteria and salmonella, are pathogenic also for Dictyostelium, favouring the use of this model to study host-pathogen interactions [9-19].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [15]
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Cites
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Self-citationPukatzki, S., Kessin, R. H., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052704399 · Cited by 289
Research works printed but not linked: 2
- Steinert M., 2002, FEMS Microbiol Rev, 743, 1
- Steinert M., 2002, Legionella - 5th International Conference on Legionella., 161
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Pukatzki, S. U., Ma, A. T., Sturtevant, D., Krastins, B., Sarracino, D. A., Nelson, W. C., Heidelberg, J. F., & Mekalanos, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510322103 · Cited by 1,116
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Lagier, J., Edouard, S., Pagnier, I., Mediannikov, O., Drancourt, M., & Raoult, D. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00110-14 · Cited by 657
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Newton, H. J., Ang, D. K. Y., van Driel, I. R., & Hartland, E. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00052-09 · Cited by 522
Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems
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The phagosome: compartment with a license to kill
Haas, A. (2007) · Traffic · doi:10.1111/j.1600-0854.2006.00531.x · Cited by 450
Metadata
- Authors
- Steinert, M., & Heuner, K.
- Affiliations
- University of Würzburg (DE)
- Corresponding author
- Steinert, Michael
- ORCID
- Steinert, Michael
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2005-03
- Volume
- 7
- Issue
- 3
- Pages
- 307-314
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2035399581
- Cited by
- 144
- References
- 51
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (STE 838/3-2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Legionella and Acanthamoeba research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Slime Mold and Myxomycetes Research
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Keywords
- Dictyostelium discoideum, host-pathogen interaction, pathogenesis, virulence screening, host resistance and susceptibility, reporter system, cell signalling pathways, Pseudomonas aeruginosa, Cryptococcus neoformans, Mycobacterium, Legionella pneumophila, intracellular pathogens, extracellular pathogens
- MeSH terms
- Animals, Cryptococcus neoformans, Dictyostelium, Mutation, Mycobacterium, Phagocytosis, Pseudomonas aeruginosa, Virulence, Legionella pneumophila, Models, Animal
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