Dictyostelium as host model for pathogenesis

A kingdom-level phylogeny of eukaryotes based on combined protein data.

Baldauf, S., Roger, A., Wenk-Siefert, I., & Doolittle, W. (2000) · Science · doi:10.1126/science.290.5493.972 · Cited by 1,243

Microorganisms Resistant to Free-Living Amoebae

Greub, G., & Raoult, D. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.413-433.2004 · Cited by 1,066

Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis

Tan, M., Mahajan‐Miklos, S., & Ausubel, F. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.715 · Cited by 1,008

Macromolecular Architecture in Eukaryotic Cells Visualized by Cryoelectron Tomography

Medalia, O., Weber, I. T., Frangakis, A. S., Nicastro, D., Gerisch, G., & Baumeister, W. P. (2002) · Science · doi:10.1126/science.1076184 · Cited by 841

Legionella PneumophilaPathogenesis: A Fateful Journey from Amoebae to Macrophages

Swanson, M. S., & Hammer, B. K. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.567 · Cited by 402

How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions.

Tzou, P., Gregorio, E. D., & Lemaître, B. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00294-1 · Cited by 399

Differentiate to thrive: lessons from the Legionella pneumophila life cycle

Molofsky, A. B., & Swanson, M. S. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04129.x · Cited by 338

Legionella Effectors That Promote Nonlytic Release from Protozoa

Chen, J. Y.-S., de Felipe, K. S., Clarke, M., Lu, H. X., Anderson, O. R., Segal, G., & Shuman, H. A. (2004) · Science · doi:10.1126/science.1094226 · Cited by 294

Legionella pneumophila: an aquatic microbe goes astray

Steinert, M., Hentschel, U., & Hacker, J. H. (2002) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2002.tb00607.x · Cited by 292

The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum

Pukatzki, S., Kessin, R. H., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052704399 · Cited by 289

The road less traveled

Roy, C. R., & Tilney, L. G. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205011 · Cited by 286

Mycobacterium aviumBacilli Grow Saprozoically in Coculture withAcanthamoeba polyphagaand Survive within Cyst Walls

Steinert, M., BIRKNESS, K. A., WHITE, E. H., Fields, B. S., & Quinn, F. D. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.6.2256-2261.1998 · Cited by 274

Pseudomonas aeruginosaVirulence Analyzed in aDictyostelium discoideumHost System

Cosson, P., Zulianello, L., Join‐Lambert, O., Faurisson, F., Gebbie, L. K., Benghezal, M., van Delden, C., Curty, L. K., & Köhler, T. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.11.3027-3033.2002 · Cited by 268

Common molecular mechanisms of symbiosis and pathogenesis

Hentschel, U., Steinert, M., & Hacker, J. H. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01758-3 · Cited by 250

Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis

Müller‐Taubenberger, A., Lupas, A. N., Li, H., Ecke, M., Simmeth, E., & Gerisch, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6772 · Cited by 242

Unexplored reservoirs of pathogenic bacteria: protozoa and biofilms

Brown, M. R. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01425-5 · Cited by 238

Intracellular Growth of Legionella pneumophila in Dictyostelium discoideum, a System for Genetic Analysis of Host-Pathogen Interactions

Solomon, J. M., Rupper, A., Cardelli, J. A., & Isberg, R. R. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2939-2947.2000 · Cited by 215 · cited 4×

The Dictyostelids

Raper, K. B. (1984) · Princeton University Press eBooks · doi:10.1515/9781400856565 · Cited by 202

Dictyostelium discoideum: a new host model system for intracellular pathogens of the genus Legionella

Hagele, S., Kohler, R., Merkert, H., Schleicher, M., Hacker, J., & Steinert, M. (2000) · Cellular Microbiology · doi:10.1046/j.1462-5822.2000.00044.x · Cited by 198

Sequence and analysis of chromosome 2 of Dictyostelium discoideum

Glöckner, G., Eichinger, L., Szafranski, K., Pachebat, J. A., Bankier, A. T., Dear, P. H., Lehmann, R., Baumgart, C., Parra, G., Abril, J. F., et al. (2002) · Nature · doi:10.1038/nature00847 · Cited by 196

Icm/Dot‐dependent upregulation of phagocytosis by Legionella pneumophila

Hilbi, H., Segal, G., & Shuman, H. A. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02645.x · Cited by 194

RNAi inDictyostelium:The Role of RNA-directed RNA Polymerases and Double-stranded RNase

Martens, H., Novotny, J., Oberstraß, J., Steck, T. L., Postlethwait, P., & Nellen, W. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-04-0211 · Cited by 177

Mechanism of phagocytosis in dictyostelium discoideum: phagocytosis is mediated by different recognition sites as disclosed by mutants with altered phagocytotic properties

Vogel, G., Thilo, L., Schwarz, H., & Steinhart, R. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.86.2.456 · Cited by 172

Cryptococcus neoformansVirulence Is Enhanced after Growth in the Genetically Malleable HostDictyostelium discoideum

Steenbergen, J. N., Nosanchuk, J. D., Malliaris, S. D., & Casadevall, A. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.4862-4872.2003 · Cited by 156

Phagocytosis and Macropinocytosis in Dictyostelium: Phosphoinositide‐Based Processes, Biochemically Distinct

Cardelli, J. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.002005311.x · Cited by 150

Intracellular Replication of Mycobacterium marinum within Dictyostelium discoideum : Efficient Replication in the Absence of Host Coronin

Solomon, J. M., Leung, G. S., & Isberg, R. R. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3578-3586.2003 · Cited by 127

The actin cytoskeleton of Dictyostelium: a story told by mutants

Noegel, A. A., & Schleicher, M. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.5.759 · Cited by 127

Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum

Otto, G. P., Wu, M., Clarke, M., Lu, H. X., Anderson, O. R., Hilbi, H., Shuman, H. A., & Kessin, R. H. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03826.x · Cited by 124

The Dot/Icm Type IV Secretion System of Legionella pneumophila Is Essential for the Induction of Apoptosis in Human Macrophages

Zink, S. D., Pedersen, L., Cianciotto, N. P., & Kwaik, Y. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1657-1663.2002 · Cited by 123

Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host–pathogen interactions

Solomon, J. M., & Isberg, R. R. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01852-7 · Cited by 112

Various bacterial pathogens and symbionts infect the amoeba Dictyostelium discoideum

Skriwan, C., Fajardo, M., Hägele, S., Horn, M., Wagner, M., Michel, R., Krohne, G., Schleicher, M., Hacker, J., & Steinert, M. (2002) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00177 · Cited by 109

Regulation of phagocytosis and endo-phagosomal trafficking pathways in Dictyostelium discoideum

Rupper, A., & Cardelli, J. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(01)00106-4 · Cited by 103

The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens

Bellamy, R. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)80010-0 · Cited by 96

Opportunistic Infections of the CNS in Patients with AIDS

Collazos, J. (2003) · CNS Drugs · doi:10.2165/00023210-200317120-00002 · Cited by 84

Disruption of the Phagosomal Membrane and Egress of Legionella pneumophila into the Cytoplasm during the Last Stages of Intracellular Infection of Macrophages and Acanthamoeba polyphaga

Molmeret, M., Bitar, D. M., Han, L., & Kwaik, Y. A. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.4040-4051.2004 · Cited by 79

Biochemical and Functional Analyses of the Mip Protein: Influence of the N-Terminal Half and of Peptidylprolyl Isomerase Activity on the Virulence of Legionella pneumophila

Köhler, R., Fanghänel, J., König, B., Lüneberg, E., Frosch, M., Rahfeld, J., Hilgenfeld, R., Fischer, G. S., Hacker, J. H., & Steinert, M. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4389-4397.2003 · Cited by 76

The flagellum of Legionella pneumophila and its link to the expression of the virulent phenotype

Heuner, K., & Steinert, M. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00259 · Cited by 74

DictyosteliumLvsB Mutants Model the Lysosomal Defects Associated with Chediak-Higashi Syndrome

Harris, E. N., Wang, N., Wu, W.-L., Weatherford, A., Lozanne, A. D., & Cardelli, J. A. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-09-0454 · Cited by 73

Calnexin, calreticulin and cytoskeleton-associated proteins modulate uptake and growth of Legionella pneumophila in Dictyostelium discoideum

Fajardo, M., Schleicher, M., Noegel, A., Bozzaro, S., Killinger, S., Heuner, K., Hacker, J., & Steinert, M. (2004) · Microbiology · doi:10.1099/mic.0.27111-0 · Cited by 73

Influence of the Alternative σ 28 Factor on Virulence and Flagellum Expression of Legionella pneumophila

Heuner, K., Dietrich, C., Skriwan, C., Steinert, M., & Hacker, J. H. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1604-1608.2002 · Cited by 71

Fusion and Fission Events in the Endocytic Pathway of Dictyostelium

Maniak, M. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.40101.x · Cited by 65

Analysis of regulatory networks in Pseudomonas aeruginosa by genomewide transcriptional profiling

Goodman, A. L. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2003.12.009 · Cited by 65

Cloning and Characterization of the Gene Encoding the Major Cell-Associated Phospholipase A of Legionella pneumophila , plaB , Exhibiting Hemolytic Activity

Flieger, A., Rydzewski, K., Banerji, S., Broich, M., & Heuner, K. (2004) · Infection and Immunity · doi:10.1128/iai.72.5.2648-2658.2004 · Cited by 65

Comparison of the Virulence of Methicillin‐Resistant and Methicillin‐Sensitive Staphylococcus aureus

Mizobuchi, S., Minami, J., Jin, F., Matsushita, O., & Okabe, A. (1994) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1994.tb01829.x · Cited by 49

Crawling into a new era—the Dictyostelium genome project

Eichinger, L., & Noegel, A. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg214 · Cited by 44

Surrogate hosts: protozoa and invertebrates as models for studying pathogen-host interactions

Steinert, M., Leippe, M., & Roeder, T. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00275 · Cited by 37

Loss of the F-Actin Binding and Vesicle-Associated Protein Comitin Leads to a Phagocytosis Defect

Schreiner, T., Mohrs, M. R., Blau‐Wasser, R., von Krempelhuber, A., Steinert, M., Schleicher, M., & Noegel, A. A. (2002) · Eukaryotic Cell · doi:10.1128/ec.1.6.906-914.2002 · Cited by 24

Editorial

Autenrieth, I. B. (2003) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00240 · Cited by 19

Mutation of the Dictyostelium fbxA Gene Affects Cell-Fate Decisions and Spatial Patterning

Ennis, H. L., Dao, D. N., Wu, M., & Kessin, R. H. (2003) · Protist · doi:10.1078/143446103322454158 · Cited by 13

Comparison of Probe Preparation Methods for DNA Microarrays

Farbrother, P., Müller, S. C., Noegel, A. A., & Eichinger, L. (2002) · BioTechniques · doi:10.2144/02334mt01 · Cited by 6

Interaction of Legionella pneumophila with Dictyostelium discoideum

Steinert, M., Hägele, S., Skriwan, C., Grimm, D. G., Fajardo, M., Heuner, K., Schleicher, M., Hentschel, U., Ludwig, W., Marre, R., et al. (2014) · ASM Press eBooks · doi:10.1128/9781555817985.ch28 · Cited by 4

Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system

Pukatzki, S. U., Ma, A. T., Sturtevant, D., Krastins, B., Sarracino, D. A., Nelson, W. C., Heidelberg, J. F., & Mekalanos, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510322103 · Cited by 1,116

Current and Past Strategies for Bacterial Culture in Clinical Microbiology

Lagier, J., Edouard, S., Pagnier, I., Mediannikov, O., Drancourt, M., & Raoult, D. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00110-14 · Cited by 657

Molecular Pathogenesis of Infections Caused by Legionella pneumophila

Newton, H. J., Ang, D. K. Y., van Driel, I. R., & Hartland, E. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00052-09 · Cited by 522

Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems

Martínez, J. L., Sánchez, M. B., Martínez‐Solano, L., Hernandez, A., Garmendia, L., Fajardo-Lubian, A., & Alvarez‐Ortega, C. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00157.x · Cited by 506

The phagosome: compartment with a license to kill

Haas, A. (2007) · Traffic · doi:10.1111/j.1600-0854.2006.00531.x · Cited by 450

Pathogen–host interactions in Dictyostelium, Legionella, Mycobacterium and other pathogens

Steinert, M. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.11.003 · Cited by 94

Screening of Virulence Traits in Legionella pneumophila and Analysis of the Host Susceptibility to Infection by Using the Dictyostelium Host Model System

Shevchuk, O., & Steinert, M. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-204-5_4 · Cited by 11

Dictyostelium discoideum as a Model to Study Host–Pathogen Interactions

Ünal, C., & Steinert, M. (2006) · Humana Press eBooks · doi:10.1385/1-59745-144-4:507 · Cited by 18

Dictyostelium Host Response to Legionella Infection: Strategies and Assays

Bozzaro, S., Peracino, B., & Eichinger, L. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-161-5_26 · Cited by 11

Legionella

Bozzaro, S., Peracino, B., & Eichinger, L. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-161-5 · Cited by 14