Cited by 144Legionella and Acanthamoeba researchSlime Mold and Myxomycetes ResearchInvertebrate Immune Response Mechanisms

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Dictyostelium as host model for pathogenesis

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Steinert, Michael, Heuner, Klaus·2005·Cellular Microbiology

DOI 10.1111/j.1462-5822.2005.00493.x

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Abstract

The haploid social soil amoeba Dictyostelium discoideum has been established as a host model for several pathogens including Pseudomonas aeruginosa, Cryptococcus neoformans, Mycobacterium spp. and Legionella pneumophila. The research areas presently pursued include (i) the use of Dictyostelium wild-type cells as screening system for virulence of extracellular and intracellular pathogens and their corresponding mutants, (ii) the use of Dictyostelium mutant cells to identify genetic host determinants of susceptibility and resistance to infection and (iii) the use of reporter systems in Dictyostelium cells which allow the dissection of the complex host-pathogen cross-talk. The body of information presented in this review demonstrates that the availability of host cell markers, the knowledge of cell signalling pathways, the completion of the genome sequencing project and the tractability for genetic studies qualifies Dictyostelium for the study of fundamental cellular processes of pathogenesis.

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Self-citation
The human pathogen Pseudomonas aeruginosa utilizes conserved virulence pathways to infect the social amoeba Dictyostelium discoideum
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Show all 51 references

Research works printed but not linked: 2

Steinert M., 2002, FEMS Microbiol Rev, 743, 1
Steinert M., 2002, Legionella - 5th International Conference on Legionella., 161

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Authors: Steinert, M., & Heuner, K.
Affiliations: University of Würzburg (DE)
Corresponding author: Steinert, Michael
ORCID: Steinert, Michael
Venue: Cellular Microbiology
Publisher: Hindawi Limited
Published: 2005-03
Volume: 7
Issue: 3
Pages: 307-314
ISSN: 1462-5814 (ISSN-L)
1462-5822
DOI: 10.1111/j.1462-5822.2005.00493.x
OpenAlex: W2035399581
Cited by: 144
References: 51
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 5
FWCI: 1.46
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3836 d)
Locations: Cellular Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (STE 838/3-2)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Legionella and Acanthamoeba research
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Slime Mold and Myxomycetes Research
Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords: Dictyostelium discoideum, host-pathogen interaction, pathogenesis, virulence screening, host resistance and susceptibility, reporter system, cell signalling pathways, Pseudomonas aeruginosa, Cryptococcus neoformans, Mycobacterium, Legionella pneumophila, intracellular pathogens, extracellular pathogens
MeSH terms: Animals, Cryptococcus neoformans, Dictyostelium, Mutation, Mycobacterium, Phagocytosis, Pseudomonas aeruginosa, Virulence, Legionella pneumophila, Models, Animal

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Dictyostelium as host model for pathogenesis

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