The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection
Open accessAbstract
Exocytosis of lysosomes from macrophages has been described as a response to microbial cytotoxins and haemolysins, as well as for releasing pro-inflammatory cytokines interleukin (IL)-1beta and IL-18 during inflammasome activation. The mycobacterial ESX-1 secretion system, encoded in part by the Region of Difference-1, is a virulence factor necessary for phagosome escape and host cell lysis by a contact-dependent haemolysin in Mycobacterium marinum. Here we show that ESX-1 from M. marinum and M. tuberculosis is required for Ca(2+)-dependent induction of lysosome secretion from macrophages. Mycobacteria-induced lysosome secretion was concurrent to release of IL-1beta and IL-18, dependent on phagocytosis of bacteria containing ESX-1. Synthesis but not release of IL-1beta and IL-18 occurred in response to dead bacilli and bacteria lacking ESX-1, indicating that only cytokine release was regulated by ESX-1. Release of these cytokines and exocytosis of lysosomes were independent of intracellular mycobacterial growth, yet correlated with mycobacteria-encoded haemolytic activity, demonstrating a parallel pathway for the two responses. We further identified inflammasome components caspase-1, ASC and NALP3, but not Ipaf, required for release of IL-1beta and IL-18. Collectively, these results reveal a role for ESX-1 in triggering secretion of lysosomes, as well as release of IL-1beta and IL-18 during mycobacteria infection.
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Cites
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells
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Ca2+ and synaptotagmin VII–dependent delivery of lysosomal membrane to nascent phagosomes
Czibener, C., Sherer, N. M., Becker, S. M., Pypaert, M., Hui, E., Chapman, E. R., Mothes, W., & Andrews, N. W. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605004 · Cited by 165
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Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,183
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Franchi, L., Muñoz-Planillo, R., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2231 · Cited by 1,012
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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
Broz, P., Newton, K., Lamkanfi, M., Mariathasan, S., Dixit, V. M., & Monack, D. M. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100257 · Cited by 549
Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium
Volkman, H. E., Pozos, T. C., Zheng, J., Davis, J. M., Rawls, J. F., & Ramakrishnan, L. (2010) · Science · doi:10.1126/science.1179663 · Cited by 448
Metadata
- Authors
- Koo, I. C., Wang, C., Raghavan, S., Morisaki, J. H., Cox, J. S., & Brown, E. J.
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2008-09
- Volume
- 10
- Issue
- 9
- Pages
- 1866-1878
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2020588519
- Cited by
- 197
- References
- 6
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. https://app.cochat.ai/papers/10.1111/j.1462-5822.2008.01177.x
- The paper
- Koo, I. C., Wang, C., Raghavan, S., Morisaki, J. H., Cox, J. S., & Brown, E. J. (2008). ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. Cellular Microbiology. https://doi.org/10.1111/j.1462-5822.2008.01177.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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