The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Sensing and reacting to microbes through the inflammasomes
Open accessAbstract
Inflammasomes are multiprotein complexes that activate caspase-1, which leads to maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the induction of pyroptosis. Members of the Nod-like receptor (NLR) family, including NLRP1, NLRP3 and NLRC4, and the cytosolic receptor AIM2 are critical components of inflammasomes and link microbial and endogenous danger signals to the activation of caspase-1. In response to microbial infection, activation of the inflammasomes contributes to host protection by inducing immune responses that limit microbial invasion, but deregulated activation of inflammasomes is associated with autoinflammatory syndromes and other pathologies. Thus, understanding inflammasome pathways may provide insight into the mechanisms of host defense against microbes and the development of inflammatory disorders.
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Cites
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A role for mitochondria in nlrp3 inflammasome activation
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Sterile inflammation: sensing and reacting to damage
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Thioredoxin-interacting protein links oxidative stress to inflammasome activation
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Non-canonical inflammasome activation targets caspase-11
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Cited by
Mechanism and Regulation of NLRP3 Inflammasome Activation
He, Y., Hara, H., & Núñez, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.09.002 · Cited by 2,759
Self-citationMolecular mechanisms regulating NLRP3 inflammasome activation
Jo, E.-K., Kim, J. K., Shin, D.-M., & Sasakawa, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.95 · Cited by 1,378
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353
STING: infection, inflammation and cancer.
Barber, G. N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3921 · Cited by 1,313
NLRP3 inflammasome and its inhibitors: a review
Shao, B.-Z., Xu, Z.-Q., Han, B.-Z., Su, D.-F., & Liu, C. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00262 · Cited by 836
“…PAMPs or DAMPs are recognized by TLRs, leading to activation of nuclear factor kappa B (NF-κB)-mediated signaling, which in turn up-regulates transcription of inflammasome-related components, including inactive NLRP3, proIL-1β, and proIL18 (Bauernfeind et al., 2009; Franchi et al., 2012, 2014).”
Background
Metadata
- Authors
- Franchi, L., Muñoz-Planillo, R., & Núñez, G.
- Venue
- Nature Immunology
- Published
- 2012-03-19
- Volume
- 13
- Issue
- 4
- Pages
- 325-332
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1966625479
- Cited by
- 1,012
- References
- 21
- FWCI
- 40.66
- Type
- journal article
- Language
- en
- Open access
- green
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