The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Galectin-3, a marker for vacuole lysis by invasive pathogens
Open accessAbstract
Shigella bacteria invade macrophages and epithelial cells and following internalization lyse the phagosome and escape to the cytoplasm. Galectin-3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection. Galectins are synthesized as cytosolic proteins and following non-classical secretion bind extracellular beta-galactosides. Here we analysed the localization of galectin-3 following entry of Shigella into the cytosol and detected a striking phenomenon. Very shortly after bacterial invasion, intracellular galectin-3 accumulated in structures in vicinity to internalized bacteria. By using immuno-electron microscopy analysis we identified galectin-3 in membranes localized in the phagosome and in tubules and vesicles that derive from the endocytic pathway. We also demonstrated that the binding of galectin-3 to host N-acetyllactosamine-containing glycans, was required for forming the structures. Accumulation of the structures was a type three secretion system-dependent process. More specifically, existence of structures was strictly dependent upon lysis of the phagocytic vacuole and could be shown also by Gram-positive Listeria and Salmonella sifA mutant. We suggest that galectin-3-containing structures may serve as a potential novel tool to spot vacuole lysis.
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Metadata
- Authors
- Paz, I., Sachse, M., Dupont, N., Mounier, J., Cederfur, C., Enninga, J., Leffler, H., Poirier, F., Prevost, M.-C., Lafont, F., & Sansonetti, P.
- Venue
- Cellular Microbiology
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 12
- Issue
- 4
- Pages
- 530-544
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2052080816
- Cited by
- 381
- References
- 72
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Paz, I., Sachse, M., Dupont, N., Mounier, J., Cederfur, C., Enninga, J., Leffler, H., Poirier, F., Prevost, M.-C., Lafont, F., & Sansonetti, P. (2010). Galectin-3, a marker for vacuole lysis by invasive pathogens. Cellular Microbiology. https://doi.org/10.1111/j.1462-5822.2009.01415.x
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