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Triggered recruitment of ESCRT machinery promotes endolysosomal repair
Abstract
A quick fix for leaky endosomes: Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network. Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health. Skowyra et al. describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrez and Carlton). The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function. This ESCRT activity is distinct from organelle disposal pathways. These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates. Science , this issue p. eaar5078 ; see also p. 33
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“For example, translocation of ESCRT to lysosomes in response to LLOMe is triggered by the efflux of lysosomal Ca2+ and subsequent recruitment of ALIX, which in turn brings other ESCRT-III components42.”
From TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress (2024) · cites this paper as [42]
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NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Nuclear envelope rupture and repair during cancer cell migration
Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J. (2016) · Science · doi:10.1126/science.aad7297 · Cited by 1,318
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
Thurston, T. L. M., Wandel, M. P., von Muhlinen, N., Foeglein, Á., & Randow, F. (2012) · Nature · doi:10.1038/nature10744 · Cited by 1,034
Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
Maejima, I., Takahashi, A., Omori, H., Kimura, T., Takabatake, Y., Saitoh, T., Yamamoto, A., Hamasaki, M., Noda, T., Isaka, Y., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.171 · Cited by 642 · cited 3×
“Organelle engulfment also requires conjugation of LC3 to the expanding autophagosome membrane (3) by the autophagy elongation complex (Fig.”
BackgroundMethodPlasma membrane deformation by circular arrays of ESCRT-III protein filaments
Hanson, P. I., Roth, R., Lin, Y., & Heuser, J. E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707031 · Cited by 427
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Research works printed but not linked: 44
- 10.1111/j.1462-5822.2009.01415.x · DOI
- 10.1038/ncomms3111 · DOI
- 10.1016/j.devcel.2016.08.003 · DOI
- 10.1073/pnas.1702615114 · DOI
- 10.4049/jimmunol.1103158 · DOI
- 10.1016/j.chom.2015.10.015 · DOI
- 10.1242/jcs.204529 · DOI
- 10.1091/mbc.E15-03-0126 · DOI
- 10.1016/j.cub.2016.06.046 · DOI
- 10.1016/j.tcb.2014.07.008 · DOI
- 10.1152/physrev.00037.2014 · DOI
- 10.1080/19491034.2017.1292191 · DOI
- 10.1126/science.1247136 · DOI
- 10.1038/ncomms6646 · DOI
- 10.1016/j.cell.2017.03.020 · DOI · Paper page
- 10.1126/science.aad7611 · DOI
- 10.15252/embj.201592484 · DOI
- 10.1016/j.ceb.2017.07.002 · DOI
- 10.1038/nrm.2016.121 · DOI
- 10.1073/pnas.87.1.83 · DOI
- 10.1080/15548627.2015.1063871 · DOI
- 10.1083/jcb.201507009 · DOI · Paper page
- 10.7554/eLife.15507 · DOI
- 10.1016/S0143-4160(96)90084-6 · DOI
- 10.1242/jcs.118836 · DOI
- 10.3390/ijms17091401 · DOI
- 10.15252/embj.201695148 · DOI
- 10.1016/j.semcdb.2017.08.014 · DOI
- 10.1016/j.tcb.2016.03.006 · DOI
- 10.1016/j.celrep.2015.05.045 · DOI
- 10.1128/JVI.01428-12 · DOI
- 10.1083/jcb.200911083 · DOI
- 10.1042/bj2190965 · DOI
- 10.1085/jgp.201210930 · DOI
- 10.1038/nrneph.2017.10 · DOI
- 10.1073/pnas.0506461102 · DOI
- 10.1073/pnas.0707206105 · DOI
- 10.1371/journal.ppat.1002232 · DOI
- 10.1073/pnas.1304932110 · DOI
- 10.1371/journal.ppat.1004390 · DOI
- 10.1371/journal.ppat.1005960 · DOI
- 10.1038/ncb2207 · DOI
- 10.14440/jbm.2014.36 · DOI
- 10.7554/eLife.02184 · DOI · Paper page
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Vietri, M., Radulovic, M., & Stenmark, H. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0177-4 · Cited by 962
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Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
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Jia, J., Claude-Taupin, A., Gu, Y., Choi, S. W., Peters, R., Bissa, B., Mudd, M. H., Allers, L., Pallikkuth, S., Lidke, K. A., et al. (2020) · Developmental Cell · doi:10.1016/j.devcel.2019.10.025 · Cited by 434
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
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Metadata
- Authors
- Skowyra, M. L., Schlesinger, P. H., Naismith, T. V., & Hanson, P. I.
- Venue
- Science
- Published
- 2018-04-06
- Volume
- 360
- Issue
- 6384
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC6195421
- Cited by
- 578
- References
- 6
- Language
- en
- Funders
- National Institute of General Medical Sciences (R01 GM122434)
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