CoChat
Sign Up
Cited by 95Advanced Glycation End Products researchDiet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic Diseases

High‐fat diet enhances visceral advanced glycation end products, nuclear O‐Glc‐Nac modification, p38 mitogen‐activated protein kinase activation and apoptosis

Li, S.‐Y., Liu, Y., Sigmon, V. K., McCort, A., Ren, J.·2005·Diabetes, Obesity and Metabolism
DOI 10.1111/j.1463-1326.2004.00387.x
Open this paper in CoChat — free account

Abstract

High‐fat diet intake often leads to obesity, insulin resistance and hypertension, which present a common and detrimental health problem. However, precise mechanism underlying tissue damage due to high‐fat diet‐induced obesity has not been carefully elucidated. The present study was designed to examine the effect of high‐fat diet intake on visceral advanced glycation end products (AGEs) formation, nuclear O ‐Glc‐NAc modification and apoptosis in heart, liver and kidney. Adult male Sprague‐Dawley weight‐matched rats were fed for 12 weeks with a high‐fat diet (45% kcal from fat) or an isocaloric low‐fat diet (10% kcal from fat). High‐fat diet feeding significantly elevated body weight. Blood pressure and heart rate were comparable between the two rat groups. Competitive enzyme‐linked immunosorbent assay showed significantly elevated serum AGE levels, visceral AGE formation, caspase‐3 activation and cytoplasmic DNA fragmentation in heart and liver but not kidney samples of high‐fat diet fed rats compared with those from low‐fat diet fed group. Western blot analysis further revealed that high‐fat diet feeding induced overt nuclear O ‐Glc‐NAc modification and p38 mitogen‐activated protein kinase activation in heart and liver although not in kidney samples of the high‐fat diet‐fed rats. Collectively, our results indicated that high‐fat diet intake is associated with obesity accompanied by elevated serum and visceral AGEs, visceral post‐translational nuclear O‐Glc‐NAcylated modification and apoptosis, which may contribute to high‐fat diet‐induced tissue damage.

Integrity signals

Registry

Crossref · 10.1111/j.1463-1326.2004.00387.x

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A 12-wk high-fat diet in rats induced obesity and elevated serum AGE levels which correlated with increased O-Glc-NAc modifications and apoptosis in cardiomyocytes, similar to apoptosis induced by hyperglycemia.

    “Ren’s group recently demonstrated that a 12-wk high-fat diet in rats induced obesity and elevated serum AGE levels which correlated with increased O-Glc-NAc modifications and apoptosis in cardiomyocytes (205) in a similar manner to the apoptosis induced by hyperglycemia (206).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [205]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Li, S. ‐., Liu, Y., Sigmon, V. K., McCort, A., & Ren, J.
Affiliations
University of Wyoming (US)
Corresponding author
Ren, J.
ORCID
Ren, J.
Venue
Diabetes, Obesity and Metabolism
Publisher
Wiley
Published
2004-11-15
Volume
7
Issue
4
Pages
448-454
ISSN
  • 1462-8902 (ISSN-L)
  • 1463-1326
DOI
10.1111/j.1463-1326.2004.00387.x
OpenAlex
W2023103979
Cited by
95
References
26
Citations by year
2025: 4 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 4
FWCI
2.79
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetes Obesity and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • Badan Riset dan Inovasi Nasional
  • National Institutes of Health (2p20rr016474-09)
  • National Center for Research Resources (P20 RR15640, RR 16474, P20RR015640)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
high-fat diet, advanced glycation end products, O-GlcNAcylation, p38 MAPK, apoptosis, caspase-3, DNA fragmentation, obesity, heart, liver, kidney, tissue damage, insulin resistance
MeSH terms
Acetylglucosaminidase, Animals, beta-N-Acetylhexosaminidases, Blood Pressure, Body Weight, Cell Nucleus, Cytoplasm, Dietary Fats, Glucose, Heart Rate, Kidney, Liver, Male, Multienzyme Complexes, Myocardium, Rats, Sprague-Dawley, Apoptosis, Caspases, p38 Mitogen-Activated Protein Kinases, Rats, Histone Acetyltransferases, Caspase 3, DNA Fragmentation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review