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Cited by 27Sexual function and dysfunction studiesHormonal and reproductive studiesEstrogen and related hormone effects

Non‐genomic effects of androgens on isolated human vascular and nonvascular penile erectile tissue

Waldkirch, Eginhard, Ückert, Stefan, Schultheiss, Dirk, Geismar, Ulrike, Bruns, Carola, Scheller, Friedemann, Jonas, Udo, Becker, Armin J. +2 more·2008·BJU International
DOI 10.1111/j.1464-410x.2007.07182.x
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Abstract

OBJECTIVES: To evaluate non‐genomic effects of testosterone and dihydrotestosterone (DHT) on isolated human cavernosal arteries (HCA) and corpus cavernosum (HCC) using organ‐bath studies and radio‐immunoassays (RIA), as non‐genomic effects of androgens are reported for vascular smooth musculature and there is evidence that the relaxant response involves a modulation of cyclic nucleotide tissue levels. MATERIALS AND METHODS: The relaxation induced by the cumulative addition of testosterone and DHT (0.01–10 µ m ) was studied using circular segments of HCA and strip preparations of HCC. To evaluate the effects of testosterone and DHT on tissue levels of cAMP and cGMP, specimens were exposed to increasing concentrations of the hormones. Forskolin and sodium nitroprusside (SNP) served as reference compounds. RESULTS: Testosterone and DHT dose‐dependently reversed the noradrenaline‐induced tension of vascular segments and HCC strips. At the maximum concentration, testosterone and DHT reduced the mean ( sd ) tension to 79.8 (4.43)% and 83.9 (10.94)%, respectively. SNP and forskolin significantly stimulated the production of cGMP and cAMP. No effects of testosterone and DHT on cGMP and cAMP levels were detected. CONCLUSION: Rapid androgen‐induced relaxation of HCA and HCC occurs via non‐genomic mechanisms. In penile erectile tissue, non‐genomic relaxant effects of testosterone and DHT are not mediated via modulation of cyclic nucleotide tissue levels. Additional studies are required to establish if non‐genomic relaxant effects are important in ensuring a basal level of perfusion to maintain overall penile function.

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Authors
Waldkirch, E., Ückert, S., Schultheiss, D., Geismar, U., Bruns, C., Scheller, F., Jonas, U., Becker, A. J., Stief, C. G., & Hedlund, P.
Affiliations
  • Lund University (SE)
  • Medizinische Hochschule Hannover (DE)
  • Ludwig-Maximilians-Universität München (DE)
Corresponding author
Ückert, Stefan
ORCID
Venue
BJU International
Publisher
Wiley
Published
2007-09-14
Volume
101
Issue
1
Pages
71-75
ISSN
  • 1464-4096 (ISSN-L)
  • 1464-410X
DOI
10.1111/j.1464-410x.2007.07182.x
OpenAlex
W2018600259
Cited by
27
References
22
Citations by year
2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • British Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
testosterone, dihydrotestosterone, penile erectile tissue, cavernosal arteries, corpus cavernosum, vasorelaxation, cyclic AMP, cyclic GMP, penile blood flow
MeSH terms
Cyclic AMP, Adult, Cyclic GMP, Humans, Male, Middle Aged, Penile Erection, Penis, Dihydrotestosterone, Testosterone, Case-Control Studies, Genome

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