The vasodilatory action of testosterone: a potassium‐channel opening or a calcium antagonistic action?
Open accessAbstract
British Journal of Pharmacology (2003) 138, 733–744. doi:10.1038/sj.bjp.0705141
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In vitro and in vivo studies have found testosterone to be a coronary vasodilator.
“In vitro and in vivo studies have found testosterone to be a coronary vasodilator.[11][12][13]”
From Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life (2004) · cites this paper as [12]
Laboratory and clinical studies have found that testosterone at normal concentrations acts as a direct vasodilator, independent of activity on androgen receptors.
“Laboratory and clinical studies have found that T at normal concentrations acts as a direct vasodilator, independent of activity on AR [17].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Physiological roles and properties of potassium channels in arterial smooth muscle
Nelson, M. T., & Quayle, J. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.4.c799 · Cited by 2,161 · see citing works
Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels
Schramm, M., Thomas, G., Towart, R., & Franckowiak, G. (1983) · Nature · doi:10.1038/303535a0 · Cited by 1,003 · see citing works
Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects
Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 986 · see citing works
Jousilahti, P., Vartiainen, E., Tuomilehto, J., & Puska, P. (1999) · Circulation · doi:10.1161/01.cir.99.9.1165 · Cited by 890 · see citing works
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases
Treiman, M., Caspersen, C. S., & Christensen, S. B. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01184-5 · Cited by 594 · see citing works
English, K. M., Steeds, R. P., Jones, T. H., Diver, M. J., & Channer, K. S. (2000) · Circulation · doi:10.1161/01.cir.102.16.1906 · Cited by 582 · see citing works
Self-citationEffects of Testosterone on Coronary Vasomotor Regulation in Men With Coronary Heart Disease
Webb, C. M., McNeill, J. G., Hayward, C. S., de Zeigler, D., & Collins, P. (1999) · Circulation · doi:10.1161/01.cir.100.16.1690 · Cited by 451 · see citing works
Testosterone Relaxes Rabbit Coronary Arteries and Aorta
Yue, P., Chatterjee, K., Beale, C., Poole-Wilson, P. A., & Collins, P. (1995) · Circulation · doi:10.1161/01.cir.91.4.1154 · Cited by 414 · see citing works
Acute Anti-Ischemic Effect of Testosterone in Men With Coronary Artery Disease
Rosano, G. M. C., Leonardo, F., Pagnotta, P., Pelliccia, F., Panina, G., Cerquetani, E., della Monica, P. L., Bonfigli, B., Volpe, M., & Chierchia, S. L. (1999) · Circulation · doi:10.1161/01.cir.99.13.1666 · Cited by 367 · see citing works
English, K. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1873 · Cited by 350 · see citing works
Testosterone Induces Dilation of Canine Coronary Conductance and Resistance Arteries In Vivo
Chou, T. M., Sudhir, K., Hutchison, S. J., Ko, E., Amidon, T. M., Collins, P. D., & Chatterjee, K. (1996) · Circulation · doi:10.1161/01.cir.94.10.2614 · Cited by 312 · see citing works
Lieberherr, M., & Grosse, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37270-8 · Cited by 275 · see citing works
Benten, W. P. M., Lieberherr, M., Stamm, O., Wrehlke, C., Guo, Z., & Wunderlich, F. T. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3113 · Cited by 253 · see citing works
Effect of acute testosterone on myocardial ischemia in men with coronary artery disease
Webb, C. M., Adamson, D. L., de Zeigler, D., & Collins, P. D. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00880-7 · Cited by 242 · see citing works
The relationship of natural androgens to coronary heart disease in males: a review
Alexandersen, P., Haarbo, J., & Christiansen, C. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05864-9 · Cited by 239 · see citing works
Deenadayalu, V. P., White, R. E., Stallone, J. N., Gao, X., & Garcia, A. J. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.4.h1720 · Cited by 212 · see citing works
THE SEX DIFFERENTIAL IN MORTALITY FROM ALL CAUSES AND ISCHEMIC HEART DISEASE
Wingard, D. L., Suarez, L., & Barrett-Connor, E. L. (1983) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113527 · Cited by 212 · see citing works
Crews, J. K., & Khalil, R. A. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.1034 · Cited by 162 · see citing works
Effect of testosterone cypionate on postexercise ST segment depression.
Jaffe, M. D. (1977) · Heart · doi:10.1136/hrt.39.11.1217 · Cited by 155 · see citing works
17β-Estradiol inhibits the voltage-dependent L-type Ca2+ currents in aortic smooth muscle cells
Nakajima, T., Kitazawa, T., Hamada, E., Hazama, H., Omata, M., & Kurachi, Y. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00602-8 · Cited by 146 · see citing works
Murphy, J. G., & Khalil, R. A. (1999) · PubMed · Cited by 142 · see citing works
Khaw, K., & Barrett-Connor, E. L. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.3.489 · Cited by 142 · see citing works
Testosterone enhances flow-mediated brachial artery reactivity in men with coronary artery disease
Ong, P. J. L., Patrizi, G., Chong, W. C. F., Webb, C. M., Hayward, C., & Collins, P. L. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00630-x · Cited by 141 · see citing works
Honda, H., Unemoto, T., & Kogo, H. (1999) · Hypertension · doi:10.1161/01.hyp.34.6.1232 · Cited by 136 · see citing works
Gender‐Specific Inhibition of Ca2+ Entry Mechanisms of Arterial Vasoconstriction by Sex Hormones
Crews, J. K., & Khalil, R. A. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03110.x · Cited by 135 · see citing works
Tep‐areenan, P., Kendall, D. A., & Randall, M. D. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704522 · Cited by 133 · see citing works
Testosterone induces Ca2+ influx via non‐genomic surface receptors in activated T cells
Benten, W. P. M., Lieberherr, M., Sekeris, C. E., & Wunderlich, F. T. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00346-3 · Cited by 133 · see citing works
Testosterone acts as a coronary vasodilator by a calcium antagonistic action
English, K. M., Jones, R. D., Jones, T. H., Morice, A. H., & Channer, K. S. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344037 · Cited by 130 · see citing works
Self-citationEnglish, K. M., Jones, R. D., Jones, T. H., Morice, A. H., & Channer, K. S. (2001) · Hormone and Metabolic Research · doi:10.1055/s-2001-18689 · Cited by 125 · see citing works
Self-citationPulmonary Vasodilatory Action of Testosterone: Evidence of a Calcium Antagonistic Action
Jones, R. D., English, K. M., Pugh, P. J., Morice, A. H., Jones, T. H., & Channer, K. S. (2002) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200206000-00006 · Cited by 123 · see citing works
Self-citationLyng, F. M., Jones, G. R., & ROMMERTS, F. F. G. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.3.736 · Cited by 122 · see citing works
Oestrogen relaxes human epicardial coronary arteries through non-endothelium-dependent mechanisms
Chester, A. H., Jiang, C., Borland, J., Yacoub, M. H., & Collins, P. D. (1995) · Coronary Artery Disease · doi:10.1097/00019501-199505000-00009 · Cited by 121 · see citing works
Ding, A. Q., & Stallone, J. N. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2742 · Cited by 119 · see citing works
Sz, W., & Xz, W. (1993) · PubMed · Cited by 107 · see citing works
Kang, S.-M., Jang, Y., Kim, J. I.-Y., Chung, N., Cho, S.-Y., Chae, J. S., & Lee, J.-H. O. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02202-6 · Cited by 105 · see citing works
Role of endothelium in the vasodilating effect of progestins and androgens on the rat thoracic aorta
Perusquı́a, M., Hernández, R., Morales, M. A., et al. (1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)00091-7 · Cited by 99 · see citing works
Estrada, M., Liberona, J. L., Miranda, M., & Jaimovich, E. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.1.e132 · Cited by 97 · see citing works
Effect of niflumic acid on noradrenaline‐induced contractions of the rat aorta
Criddle, D. N., de Moura, R. S., Greenwood, I. A., et al. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15507.x · Cited by 91 · see citing works
Nongenomic Testosterone Calcium Signaling
Guo, Z., Benten, W. P. M., Krücken, J., & Wunderlich, F. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202997200 · Cited by 89 · see citing works
TESTOSTERONE PROPIONATE THERAPY IN ONE HUNDRED CASES OF ANGINA PECTORIS
Lesser, M. A. (1946) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-6-8-549 · Cited by 87 · see citing works
Jones, R., Pugh, P., Hall, J., Channer, K. S., & Jones, T. H. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480111 · Cited by 82 · see citing works
Self-citationEvidence for a Ca(2+)-gated ryanodine-sensitive Ca2+ release channel in visceral smooth muscle.
Xu, L., Lai, F. A., Cohn, A. H., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3294 · Cited by 73 · see citing works
Testosterone Propionate in the Treatment of Angina Pectoris
HAMM, L. (1942) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-2-5-325 · Cited by 70 · see citing works
WALKER, T. C. (1942) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-2-9-560 · Cited by 64 · see citing works
Relaxant Effects of 17-β-Estradiol in Cerebral Arteries through Ca 2+ Entry Inhibition
Salom, J. B., Burguete, M. C., Pérez-Asensio, F. J., Torregrosa, G., & Alborch, E. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00011 · Cited by 64 · see citing works
Possible role of Ca2+ channels in the vasodilating effect of 5β-dihydrotestosterone in rat aorta
Perusquı́a, M., & Villalón, C. M. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00161-2 · Cited by 62 · see citing works
Testosterone and coronary heart disease: is there a link?
English, K. M., Steeds, R. P., Jones, T. H., & Channer, K. S. (1997) · QJM · doi:10.1093/qjmed/90.12.787 · Cited by 59 · see citing works
Self-citationEnglish, K. M., Jones, R. D., Jones, H. T., et al. (2000) · Clinical Science · doi:10.1042/cs0990077 · Cited by 47 · see citing works
Self-citationDuell, P. B. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.1990.00390220065013 · Cited by 45 · see citing works
The Treatment of Angina Pectoris with Testosterone Propionate
Lesser, M. A. (1942) · New England Journal of Medicine · doi:10.1056/nejm194201082260203 · Cited by 40 · see citing works
The Treatment of Angina Pectoris with Testosterone Propionate
Waldman, S. (1945) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-5-7-305 · Cited by 29 · see citing works
Alterations of Lipid Metabolism in Men with Hypotestosteronemia
Hromadová, M., Hácik, T., Malatinský, E., et al. (1991) · Hormone and Metabolic Research · doi:10.1055/s-2007-1003708 · Cited by 27 · see citing works
Intracellular Ca2+ elevation and contraction due to prostaglandin F2α in rat aorta
Tosun, M., Paul, R. J., & Rapoport, R. M. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01415-5 · Cited by 17 · see citing works
Tanaka, Y., Imai, T., Igarashi, T., et al. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000272 · Cited by 15 · see citing works
Duell, P. B. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.150.11.2317 · Cited by 12 · see citing works
Vascular actions of 17β‐oestradiol in rat aorta and mesenteric artery
Browne, M., Connolly, C., & Docherty, J. R. (1999) · Journal of Autonomic Pharmacology · doi:10.1046/j.1365-2680.1999.00149.x · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Khaw, K.-T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., Welch, A., & Day, N. (2007) · Circulation · doi:10.1161/circulationaha.107.719005 · Cited by 743 · see citing works
Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer
Saigal, C. S., Gore, J. L., Krupski, T. L., Hanley, J., Schonlau, M., & Litwin, M. S. (2007) · Cancer · doi:10.1002/cncr.22933 · Cited by 542 · see citing works
Androgens, insulin resistance and vascular disease in men
Kapoor, D., Malkin, C. J., Channer, K. S., & Jones, T. H. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02299.x · Cited by 317 · see citing works
Self-citationMalkin, C. J., Pugh, P. J., Morris, P. D., Kerry, K. E., Jones, R. D., Jones, T. H., & Channer, K. S. (2004) · Heart · doi:10.1136/hrt.2003.021121 · Cited by 250 · see citing works
Self-citationTestosterone replacement therapy: current trends and future directions
Nieschlag, E., Behre, H. M., Bouchard, P., Corrales, J. J., Jones, T. H., Stalla, G. K., Webb, S. M., & Wu, F. C. W. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh035 · Cited by 224 · see citing works
Self-citationLow Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men
AKISHITA, M., HASHIMOTO, M., OHIKE, Y., OGAWA, S., IIJIMA, K., ETO, M., & OUCHI, Y. (2007) · Hypertension Research · doi:10.1291/hypres.30.1029 · Cited by 179 · see citing works
Groti, K., Žuran, I., Antonič, B., Foršnarič, L., & Pfeifer, M. (2018) · The Aging Male · doi:10.1080/13685538.2018.1468429 · Cited by 117 · see citing works
Effect of testosterone on <i>ex vivo</i> vascular reactivity in man
Malkin, C. J., Jones, R. D., Jones, T. H., & Channer, K. S. (2006) · Clinical Science · doi:10.1042/cs20050354 · Cited by 81 · see citing works
Self-citationNon‐genomic effects of androgens on isolated human vascular and nonvascular penile erectile tissue
Waldkirch, E., Ückert, S., Schultheiss, D., Geismar, U., Bruns, C., Scheller, F., Jonas, U., Becker, A. J., Stief, C. G., & Hedlund, P. (2008) · BJU International · doi:10.1111/j.1464-410x.2007.07182.x · Cited by 27 · see citing works
- Authors
- Jones, R. D., Pugh, P. J., Jones, T. H., & Channer, K. S.
- Affiliations
- University of Sheffield (GB)
- Royal Hallamshire Hospital (GB)
- Barnsley Hospital (GB)
- Corresponding author
- Jones, Richard D
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2003-03
- Volume
- 138
- Issue
- 5
- Pages
- 733-744
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1573742
- OpenAlex
- W2067549251
- Cited by
- 153
- References
- 56
- Citations by year
- 2026: 6 · 2025: 4 · 2023: 8 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 10 · 2013: 7 · 2012: 8
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- testosterone, vasodilation, potassium channels, calcium channel blockade, smooth muscle relaxation, vascular smooth muscle
- MeSH terms
- Animals, Calcium, Calcium Channel Blockers, Humans, Testosterone, Vasodilation, Vasodilator Agents, Potassium Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
