The Effect of Intravenous Metformin on Glucose Metabolism During Hyperglycaemia in Type 2 Diabetes
Abstract
A stepped intravenous metformin infusion was used in conjunction with the hyperglycaemic clamp technique to study the dose-response relationship of plasma metformin concentration with hepatic glucose production and peripheral glucose disposal in nine patients with Type 2 diabetes. The study was of double-blind crossover design, using NaCl infusion as control. Plasma metformin concentrations spanning the therapeutic range (1.64 +/- 0.13 mg l-1 and 6.57 +/- 0.61 mg l-1) were achieved. No differences in peripheral glucose disposal were demonstrated when compared with NaCl infusion (3.4 +/- 0.1 vs 3.6 +/- 0.2 (+/- SE) mg kg-1 min-1 and 3.4 +/- 0.2 vs 3.3 +/- 0.2 mg kg-1 min-1, respectively). There was also no difference in basal hepatic glucose production during metformin and NaCl infusion (2.7 +/- 0.3 vs 2.8 +/- 0.2 mg kg-1 min-1). No acute effect of metformin on hepatic glucose production or peripheral glucose disposal was observed, implying that a chronic persistent effect is more important in these respects than immediate effects consequent upon changes in plasma drug level.
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IV administered metformin is ineffective in lowering hyperglycemia.
“Additional support for the importance of gut-mediated mechanisms for metformin’s actions is the knowledge that IV administered metformin is ineffective in lowering hyperglycemia and was demonstrated using a hyperglycemic clamp technique to determine the relationship between plasma metformin concentration and hepatic glucose production and disposal in T2DM patients (92).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [92]
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- Authors
- Sum, C. ‐., Webster, J. M., Johnson, A. B., Catalano, C., Cooper, B. G., & Taylor, R.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Taylor, R.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 1992-01-02
- Volume
- 9
- Issue
- 1
- Pages
- 61-65
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W1989252129
- Cited by
- 103
- References
- 16
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- metformin, type 2 diabetes, hyperglycemia, hepatic glucose production, glucose metabolism, dose-response relationship, plasma drug concentration, hyperglycaemic clamp, intravenous infusion
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 2, Female, Humans, Hyperglycemia, Infusions, Intravenous, Insulin, Male, Metformin, Middle Aged
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