Repurposing Metformin in Nondiabetic People With HIV: Influence on Weight and Gut Microbiota

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

DADA2: High–resolution sample inference from Illumina amplicon data

Callahan, B. J., McMurdie, P. J., Rosen, M. J., Han, A. W., Johnson, A. J. A., & Holmes, S. P. (2016) · Nature Methods · doi:10.1038/nmeth.3869 · Cited by 35,698 · see citing works

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

Quast, C., Pruesse, E., Yilmaz, P., Gerken, J., Schweer, T., Yarza, P., Peplies, J., & Glöckner, F. O. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1219 · Cited by 33,055 · see citing works

phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data

McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,013 · see citing works

Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy

Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works

Metagenomic biomarker discovery and explanation

Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559 · see citing works

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study

Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357 · see citing works

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322269111 · Cited by 2,175 · see citing works

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

MetaHIT consortium, Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., et al. (2015) · Nature · doi:10.1038/nature15766 · Cited by 2,116 · see citing works

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

Wu, H., Esteve, E., Tremaroli, V., Khan, M. T., Caesar, R., Mannerås-Holm, L., Ståhlman, M., Olsson, L. M., Serino, M., Planas-Fèlix, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4345 · Cited by 1,632 · see citing works

An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550 · see citing works

Metformin improves healthspan and lifespan in mice

Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works

cutPrimers: A New Tool for Accurate Cutting of Primers from Reads of Targeted Next Generation Sequencing

Андреевич, К. А., Boyarskikh, U. A., Kel, A. E., & Филипенко, М. Л. (2017) · Journal of Computational Biology · doi:10.1089/cmb.2017.0096 · Cited by 1,378 · see citing works

Butyrate: A Double-Edged Sword for Health?

Liu, H., Wang, J., He, T., Becker, S. R., Zhang, G., Li, D., & Ma, X. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx009 · Cited by 1,158 · see citing works

Weight Gain Following Initiation of Antiretroviral Therapy: Risk Factors in Randomized Comparative Clinical Trials

Sax, P. E., Erlandson, K. M., Lake, J. E., McComsey, G. A., Orkin, C. M., Eßer, S., Brown, T. T., Rockstroh, J. K., Wei, X., Carter, C. C., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz999 · Cited by 775 · see citing works

Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

Vujkovic-Cvijin, I., Dunham, R. M., Iwai, S., Maher, M. C., Albright, R. G., Broadhurst, M. J., Hernandez, R. D., Lederman, M. M., Huang, Y., Somsouk, M., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006438 · Cited by 734 · see citing works

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

Li, Z., Yi, C.-X., Katiraei, S., Kooijman, S., Zhou, E., Chung, C. K., Gao, Y., van den Heuvel, J. K., Meijer, O. C., Berbée, J. F. P., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314050 · Cited by 674 · see citing works

Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1 and SKN-1

Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671 · see citing works

HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

Serrano-Villar, S., Sainz, T., Lee, S. A., Hunt, P. W., Sinclair, E., Shacklett, B. L., Ferre, A. L., Hayes, T. L., Somsouk, M., Hsue, P. Y., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004078 · Cited by 611 · see citing works

GDF15 mediates the effects of metformin on body weight and energy balance

Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., et al. (2020) · Nature · doi:10.1038/s41586-019-1911-y · Cited by 584 · see citing works

Human Antimicrobial Peptides: Defensins, Cathelicidins and Histatins

Smet, K. D., & Contreras, R. (2005) · Biotechnology Letters · doi:10.1007/s10529-005-0936-5 · Cited by 561 · see citing works

An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia

Dillon, S. M., Lee, E. J., Kotter, C. V., Austin, G. L., Dong, Z. M., Hecht, D. K., Gianella, S., Siewe, B. T., Smith, D. M., LANDAY, A. L., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2013.116 · Cited by 533 · see citing works

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer

Reunanen, J., Kainulainen, V., Huuskonen, L., Ottman, N., Belzer, C., Huhtinen, H., de Vos, W. D., & Satokari, R. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.04050-14 · Cited by 510 · see citing works

Microbial Translocation in the Pathogenesis of HIV Infection and AIDS

Marchetti, G. C., Tincati, C., & Silvestri, G. (2013) · Clinical Microbiology Reviews · doi:10.1128/cmr.00050-12 · Cited by 502 · see citing works

A time to fast

Francesco, A. D., Germanio, C. D., Bernier, M., & de Cabo, R. (2018) · Science · doi:10.1126/science.aau2095 · Cited by 497 · see citing works

Alterations in the Gut Microbiota Associated with HIV-1 Infection

Lozupone, C., Li, M., Campbell, T., Flores, S. C., Linderman, D. J., Gebert, M. J., Knight, R. D., Fontenot, A. P., & Palmer, B. E. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.08.006 · Cited by 489 · see citing works

Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts

Belzer, C., Chia, L. W., Aalvink, S., Chamlagain, B., Piironen, V. I., Knol, J., & de Vos, W. M. (2017) · mBio · doi:10.1128/mbio.00770-17 · Cited by 445 · see citing works

Metformin Inhibits the Inflammatory Response Associated With Cellular Transformation and Cancer Stem Cell Growth

Hirsch, H. A., Iliopoulos, D., & Struhl, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221055110 · Cited by 440 · see citing works

A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

Mutlu, E., Keshavarzian, A., Losurdo, J., Swanson, G. R., Siewe, B. T., Forsyth, C. B., French, A. L., Demarais, P., Sun, Y., Koenig, L., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003829 · Cited by 438 · see citing works

Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans

Stekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.016 · Cited by 412 · see citing works

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

Day, E. A., Ford, R. J., Smith, B. K., Mohammadi-Shemirani, P., Morrow, M. R., Gutgesell, R. M., Lu, R., Raphenya, A. R., Kabiri, M., McArthur, A. G., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0146-4 · Cited by 307 · see citing works

Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals

Vázquez-Castellanos, J. F., Villar, S. S., Latorre, A., Artacho, A., Ferrús, M. L., Madrid, N., Vallejo, A., Sainz, T., Martı́nez-Botas, J., Ferrando‐Martínez, S., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.107 · Cited by 303 · see citing works

Gut microbiota diversity predicts immune status in HIV-1 infection

Nowak, P., Trøseid, M., Avershina, E., Barqasho, B., Neogi, U., Holm, K., Hov, J. R., Noyan, K., Vesterbacka, J., Svärd, J., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000869 · Cited by 298 · see citing works

Brief Report: Weight Gain in Persons With HIV Switched From Efavirenz-Based to Integrase Strand Transfer Inhibitor–Based Regimens

Norwood, J., Turner, M. M., Bofill, C., Rebeiro, P. F., Shepherd, B. E., Bebawy, S. S., Hulgan, T., Raffanti, S. P., Haas, D. W., Sterling, T. R., et al. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001525 · Cited by 285 · see citing works

Treatment with camu camu ( Myrciaria dubia ) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice

Anhê, F. F., Nachbar, R. T., Varin, T. V., Trottier, J., Dudonné, S., Barz, M. L., Feutry, P., Pilon, G., Barbier, O., Desjardins, Y., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315565 · Cited by 272 · see citing works

Weight gain and integrase inhibitors

Eckard, A. R., & McComsey, G. A. (2019) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000616 · Cited by 212 · see citing works

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Roberti, M. P., Yonekura, S., Duong, C. P. M., Picard, M., Ferrere, G., Tidjani Alou, M., Rauber, C., Iebba, V., Lehmann, C. H. K., Amon, L., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0882-8 · Cited by 208 · see citing works

HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases

Vujkovic-Cvijin, I., Sortino, O., Verheij, E., Sklar, J., Wit, F. W. N. M., Kootstra, N. A., Sellers, B. A., Brenchley, J. M., Ananworanich, J., van der Loeff, M. F. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16222-8 · Cited by 203 · see citing works

Metformin-Induced Changes of the Gut Microbiota in Healthy Young Men: Results of a Non-Blinded, One-Armed Intervention Study

Bryrup, T., Thomsen, C. W., Kern, T., Allin, K. H., Brandslund, I., Jørgensen, N. R., Vestergaard, H., Hansen, T., Hansen, T. H., Pedersen, O., et al. (2019) · Diabetologia · doi:10.1007/s00125-019-4848-7 · Cited by 200 · see citing works

Weight Gain and Incident Diabetes Among HIV-Infected Veterans Initiating Antiretroviral Therapy Compared With Uninfected Individuals

Herrin, M. A., Tate, J. P., Akgün, K. M., Butt, A. A., Crothers, K. A., Freiberg, M. S., Gibert, C. L., Leaf, D. A., Rimland, D., Rodriguez‐Barradas, M. C., et al. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001071 · Cited by 193 · see citing works

Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma: A Phase 2 Randomized Clinical Trial

Arrieta, O., Barrón, F., Padilla, M.-Á. S., Avilés-Salas, A., Ramírez-Tirado, L. A., Arguelles Jiménez, M. J., Vergara, E., Zatarain-Barrón, Z. L., Hernández-Pedro, N., Cardona, A. F., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2019.2553 · Cited by 179 · see citing works

HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration

Vujkovic-Cvijin, I., & Somsouk, M. (2019) · Current HIV/AIDS Reports · doi:10.1007/s11904-019-00441-w · Cited by 175 · see citing works

β-Defensins: Farming the Microbiome for Homeostasis and Health

Meade, K. G., & O’Farrelly, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03072 · Cited by 172 · see citing works

Inhibition of Inducible Nitric-oxide Synthase by Activators of AMP-activated Protein Kinase

Pilon, G., Dallaire, P., & Marette, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401390200 · Cited by 167 · see citing works

Short‐term weight gain after antiretroviral therapy initiation and subsequent risk of cardiovascular disease and diabetes: the D : A : D study

Achhra, A. C., Mocroft, A., Reiss, P., Sabin, C. A., Ryom, L., Wit, S. D., Smith, C. J., Monforte, A. D., Phillips, A. N., Weber, R. K., et al. (2015) · HIV Medicine · doi:10.1111/hiv.12294 · Cited by 163 · see citing works

Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients

Lu, W., Feng, Y., Jing, F., Han, Y., Lyu, N., Liu, F., Li, J., Song, X., Xie, J., Qiu, Z., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01451 · Cited by 150 · see citing works

Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells

Kim, S. A., & Choi, H. C. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.165 · Cited by 149 · see citing works

Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach

Chia, L. W., Hornung, B., Aalvink, S., Schaap, P. J., de Vos, W. M., Knol, J., & Belzer, C. (2018) · Antonie van Leeuwenhoek · doi:10.1007/s10482-018-1040-x · Cited by 142 · see citing works

Evolution of the gut microbiome following acute HIV-1 infection

Rocafort, M., Noguera-Julián, M., Rivera, J., Pastor, L., Guillén, Y., Langhorst, J., Parera, M., Mandomando, I., Carrillo, J., Urrea, V., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0687-5 · Cited by 137 · see citing works

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Elbere, I., Kalniņa, I., Silamiķelis, I., Konrāde, I., Zaharenko, L., Sekace, K., Radoviča-Spalviņa, I., Frīdmanis, D., Gudrā, D., Pīrāgs, V., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204317 · Cited by 134 · see citing works

The Effect of Dolutegravir on the Pharmacokinetics of Metformin in Healthy Subjects

Song, I. H., Zong, J., Borland, J., Jerva, F., Wynne, B., Zamek‐Gliszczynski, M. J., Humphreys, J. E., Bowers, G. D., & Choukour, M. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000983 · Cited by 125 · see citing works

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation

Ouyang, J., Lin, J., Isnard, S., Fombuena, B., Peng, X., Marette, A., Routy, B., Messaoudene, M., Chen, Y., & Routy, J.-P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00645 · Cited by 124 · see citing works

Fecal Microbiota Composition Drives Immune Activation in HIV-infected Individuals

Neff, C. P., Krueger, O., Xiong, K., Arif, S. J., Nusbacher, N. M., Schneider, J. M., Cunningham, A. W., Armstrong, A. J. S., Li, S., McCarter, M. D., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.03.024 · Cited by 118 · see citing works

Metabolic and Skeletal Complications of HIV Infection

Morse, C. G., & Kovacs, J. A. (2006) · JAMA · doi:10.1001/jama.296.7.844 · Cited by 109 · see citing works

The Effect of Intravenous Metformin on Glucose Metabolism During Hyperglycaemia in Type 2 Diabetes

Sum, C. ‐., Webster, J. M., Johnson, A. B., Catalano, C., Cooper, B. G., & Taylor, R. (1992) · Diabetic Medicine · doi:10.1111/j.1464-5491.1992.tb01716.x · Cited by 103 · see citing works

Serious Non-AIDS Events: Therapeutic Targets of Immune Activation and Chronic Inflammation in HIV Infection

Hsu, D. C., & Sereti, I. (2016) · Drugs · doi:10.1007/s40265-016-0546-7 · Cited by 102 · see citing works

Nonalcoholic fatty liver disease diagnosed by transient elastography with controlled attenuation parameter in unselected HIV monoinfected patients

Vuille‐Lessard, É., Lebouché, B., Lennox, L., Routy, J., Costiniuk, C. T., Pexos, C., Giannakis, A., Szabo, J., Klein, M. B., & Sebastiani, G. (2016) · AIDS · doi:10.1097/qad.0000000000001241 · Cited by 102 · see citing works

A retrospective analysis of weight changes in HIV-positive patients switching from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing treatment regimen in one German university hospital in 2015–2017

Gomez, M., Seybold, U., Roider, J., Härter, G., & Bogner, J. R. (2018) · Infection · doi:10.1007/s15010-018-1227-0 · Cited by 100 · see citing works

Inflammatory and immunometabolic consequences of gut dysfunction in HIV: Parallels with IBD and implications for reservoir persistence and non-AIDS comorbidities

Alzahrani, J., Hussain, T., Simar, D., Palchaudhuri, R., Abdel‐Mohsen, M., Crowe, S. M., Mbogo, G. W., & Palmer, C. S. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.07.027 · Cited by 100 · see citing works

The effects of metformin on gut microbiota and the immune system as research frontiers

Pollak, M. (2017) · Diabetologia · doi:10.1007/s00125-017-4352-x · Cited by 98 · see citing works

Richer gut microbiota with distinct metabolic profile in HIV infected Elite Controllers

Vesterbacka, J., Rivera, J., Noyan, K., Parera, M., Neogi, U., Calle, M., Paredes, R., Sönnerborg, A., Noguera-Julián, M., & Nowak, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-06675-1 · Cited by 94 · see citing works

Metformin inhibits nuclear factor κB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits

Li, S.-N., Wang, X., Zeng, Q.-T., Feng, Y.-B., Cheng, X., Mao, X.-B., Wang, T.-H., & Deng, H.-P. (2009) · Heart and Vessels · doi:10.1007/s00380-008-1137-7 · Cited by 88 · see citing works

Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling

Rosário, D., Benfeitas, R., Bidkhori, G., Zhang, C., Uhlén, M., Shoaie, S., & Mardinoğlu, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00775 · Cited by 85 · see citing works

Interplay between gut microbiota metabolism and inflammation in HIV infection

Vázquez-Castellanos, J. F., Villar, S. S., Jiménez‐Hernández, N., del Rio, M. D. L. D. S., Gayo, S., Rojo, D., Ferrer, M., Barbas, C., Moreno, S., Estrada, V., et al. (2018) · The ISME Journal · doi:10.1038/s41396-018-0151-8 · Cited by 80 · see citing works

Circulating LPS and (1→3)-β-D-Glucan: A Folie à Deux Contributing to HIV-Associated Immune Activation

Ramendra, R., Isnard, S., Mehraj, V., Chen, J., Zhang, Y., Finkelman, M., & Routy, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00465 · Cited by 66 · see citing works

Metformin effect on gut microbiota: insights for HIV-related inflammation

Ouyang, J., Isnard, S., Lin, J. C.-Y., Fombuena, B., Marette, A., Routy, B., Chen, Y., & Routy, J. (2020) · AIDS Research and Therapy · doi:10.1186/s12981-020-00267-2 · Cited by 58 · see citing works

The Interplay between Defensins and Microbiota in Crohn’s Disease

Coretti, L., Natale, A., Cuomo, M., Florio, E., Keller, S., Lembo, F., Chiariotti, L., & Pero, R. (2017) · Mediators of Inflammation · doi:10.1155/2017/8392523 · Cited by 54 · see citing works

Impact of Human Immunodeficiency Virus–Related Gut Microbiota Alterations on Metabolic Comorbid Conditions

Gelpi, M., Vestad, B., Hansen, S. H., Holm, K., Drivsholm, N., Goetz, A. E., Kirkby, N. S., Lindegaard, B., Lebech, A., Hoel, H., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz1235 · Cited by 53 · see citing works

Fatty acids as biomarkers of total dairy and dairy fat intakes: a systematic review and meta-analysis

Pranger, I. G., Joustra, M. L., Corpeleijn, E., Muskiet, F. A. J., Kema, I. P., Elferink, S. J. W. H. O., Singh‐Povel, C. M., & Bakker, S. J. L. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy048 · Cited by 48 · see citing works

Effects of metformin extended release compared to immediate release formula on glycemic control and glycemic variability in patients with type 2 diabetes

Derosa, G., D’Angelo, A., Romano, D., & Maffioli, P. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s131670 · Cited by 47 · see citing works

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol

Routy, J., Isnard, S., Mehraj, V., Ostrowski, M., Chomont, N., Ancuța, P., Ponte, R., Planas, D., Dupuy, F. P., & Angel, J. B. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028444 · Cited by 45 · see citing works

Metformin modulates human leukocyte/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients

Victor, V. M., Rovira-Llopis, S., Bañuls, C., Diaz-Morales, N., Lopez-Domenech, S., Escribano-López, I., Rios-Navarro, C., Alvarez, A., Gomez, M., Rocha, M., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.07.017 · Cited by 44 · see citing works

Relationship between Body Mass Index and Mortality in HIV-Infected HAART Users in the Women's Interagency HIV Study

Sharma, A., Hoover, D. R., Shi, Q., Gustafson, D., Plankey, M. W., Hershow, R. C., Tien, P. C., Golub, E. T., & Anastos, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143740 · Cited by 44 · see citing works

Policies, Guidelines and Consensus Statements: Pharmacologic Management of Type 2 Diabetes–2015 Interim Update

Harper, W., CLEMENT, M. A., Goldenberg, R., Hanna, A., Main, A., Retnakaran, R. R., Sherifali, D., Woo, V. C., Yale, J., & CHENG, A. Y. Y. (2015) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.05.009 · Cited by 37 · see citing works

The effect of dolutegravir on the pharmacokinetics of metformin in healthy subjects

Zong, J., Borland, J., Jerva, F., Wynne, B., Choukour, M., & Song, I. H. (2014) · Journal of the International AIDS Society · doi:10.7448/ias.17.4.19584 · Cited by 34 · see citing works

Risk of Colorectal Cancer and Associated Mortality in HIV: A Systematic Review and Meta-Analysis

O’Neill, T. J., Nguemo, J., Tynan, A., Burchell, A. N., & Antoniou, T. (2017) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001433 · Cited by 34 · see citing works

Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

Shikuma, C. M., Chew, G. M., Kohorn, L. B., Souza, S. A., Chow, D. C., SahBandar, I. N., Park, E. Y., Hanks, N., Gangcuangco, L. M. A., Gerschenson, M., et al. (2019) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2019.0078 · Cited by 33 · see citing works

Distinct gut microbiota profile in antiretroviral therapy-treated perinatally HIV-infected patients associated with cardiac and inflammatory biomarkers

Sessa, L., Reddel, S., Manno, E. C., Quagliariello, A., Cotugno, N., CHIERICO, F. D., Amodio, D., Capponi, C., Leone, F., Bernardi, S., et al. (2019) · AIDS · doi:10.1097/qad.0000000000002131 · Cited by 32 · see citing works

The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research

Mehraj, V., Ghali, P., Ramendra, R., Costiniuk, C. T., Lebouché, B., Ponte, R., Reinhard, R. J., Sousa, J., Chomont, N., Cohen, É. A., et al. (2017) · Journal of Virus Eradication · doi:10.1016/s2055-6640(20)30316-2 · Cited by 16 · see citing works

Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System

Peng, X., Ouyang, J., Isnard, S., Lin, J. C.-Y., Fombuena, B., Zhu, B., & Routy, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.596631 · Cited by 122 · see citing works

LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

Planas, D., Pagliuzza, A., Ponte, R., Fert, A., Marchand, L. R., Massanella, M., Gosselin, A., Mehraj, V., Dupuy, F. P., Isnard, S., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103270 · Cited by 68 · see citing works

GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer

Ahmed, D. S., Isnard, S., Lin, J. C.-Y., Routy, B., & Routy, J. (2020) · Journal of Cancer · doi:10.7150/jca.50376 · Cited by 66 · see citing works

Metformin and Its Immune-Mediated Effects in Various Diseases

Nojima, I., & Wada, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010755 · Cited by 54 · see citing works

Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation

Mezhibovsky, E., Knowles, K. A., He, Q., Sui, K., Tveter, K. M., Duran, R. M., & Roopchand, D. E. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.675267 · Cited by 46 · see citing works

Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity

Ahmed, D. S., Isnard, S., Berini, C. A., Lin, J. C.-Y., Routy, J., & Royston, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.820350 · Cited by 44 · see citing works

Frailty and HIV: Moving from Characterization to Intervention

Erlandson, K. M., & Piggott, D. A. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00554-1 · Cited by 41 · see citing works

GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin

Ouyang, J., Isnard, S., Lin, J., Fombuena, B., Peng, X., Chen, Y., & Routy, J.-P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.581839 · Cited by 39 · see citing works

Gut Leakage of Fungal‐Related Products: Turning Up the Heat for HIV Infection

Isnard, S., Lin, J. C.-Y., Bu, S., Fombuena, B., Royston, L., & Routy, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656414 · Cited by 35 · see citing works

Probing the Interface of HIV and Inflammaging

Sieg, S. F., Shive, C. L., Panigrahi, S., & Freeman, M. L. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00547-0 · Cited by 33 · see citing works

Future indications and clinical management for fecal microbiota transplantation (FMT) in immuno-oncology

Jamal, R., Messaoudene, M., de Figuieredo, M., & Routy, B. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101754 · Cited by 31 · see citing works

In vitro co-metabolism of epigallocatechin-3-gallate (EGCG) by the mucin-degrading bacterium Akkermansia muciniphila

Xia, Y. L., Zhang, X., Jiang, M., Zhang, H., Wang, Y., Zhang, Y., Seviour, R. J., & Kong, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260757 · Cited by 30 · see citing works

HIV and comorbidities – the importance of gut inflammation and the kynurenine pathway

MacCann, R., LANDAY, A. L., & Mallon, P. W. G. (2022) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000782 · Cited by 25 · see citing works

Systematic review of gut microbiota composition, metabolic alterations, and the effects of treatments on PCOS and gut microbiota across human and animal studies

Hanna, A., Abbas, H., Yassine, F., Albush, A., & Bilen, M. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1549499 · Cited by 23 · see citing works

(5R)-5-hydroxytriptolide for HIV immunological non-responders receiving ART: a randomized, double-blinded, placebo-controlled phase II study

Cao, W., Liu, X., Han, Y., Song, X., Lu, L., Li, X., Lin, L., Sun, L., Liu, A., Zhao, H., et al. (2023) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2023.100724 · Cited by 22 · see citing works

Cytomegalovirus as an Uninvited Guest in the Response to Vaccines in People Living with HIV

Royston, L., Isnard, S., Lin, J. C.-Y., & Routy, J. (2021) · Viruses · doi:10.3390/v13071266 · Cited by 19 · see citing works

Increased susceptibility to pneumonia due to tumour necrosis factor inhibition and prospective immune system rescue via immunotherapy

Ha, R., Keynan, Y., & Rueda, Z. V. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.980868 · Cited by 18 · see citing works

Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV

Ramirez, C. E., Agarwal, N., Cox, A. R., Hartig, S. M., Lake, J. E., & Balasubramanyam, A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad028 · Cited by 19 · see citing works

North American clinical practice guidelines for the medical management of hidradenitis suppurativa in special patient populations

Alhusayen, R. O., Dienes, S., Lam, M., Alavi, A., Alikhan, A., Aleshin, M. A., Bahashwan, E., Daveluy, S. D., Goldfarb, N. I., Garg, A., et al. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2024.11.071 · Cited by 16 · see citing works

Alcohol Use and Abuse Conspires With HIV Infection to Aggravate Intestinal Dysbiosis and Increase Microbial Translocation in People Living With HIV: A Review

Yan, J., Ouyang, J., Isnard, S., Zhou, X., Harypursat, V., Routy, J., & Chen, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.741658 · Cited by 15 · see citing works

Association between gut microbiota and prediabetes in people living with HIV

Jayanama, K., Phuphuakrat, A., Pongchaikul, P., Prombutara, P., Nimitphong, H., Reutrakul, S., & D, S. S. M. (2022) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2022.100143 · Cited by 14 · see citing works

Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies

Fert, A., Richard, J., Marchand, L. R., Planas, D., Routy, J., Chomont, N., Finzi, A., & Ancuța, P. (2024) · iScience · doi:10.1016/j.isci.2024.110670 · Cited by 14 · see citing works

Elevated CD4+ T-cell glucose metabolism in HIV+ women with diabetes mellitus

Butterfield, T. R., Hanna, D. B., Kaplan, R. C., Xue, X., Kizer, J. R., Durkin, H. G., Kassaye, S. G., Nowicki, M., Tien, P. C., Topper, E. T., et al. (2022) · AIDS · doi:10.1097/qad.0000000000003272 · Cited by 10 · see citing works

Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter

Rezaei, S., Timani, K. A., & He, J. J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0705 · Cited by 10 · see citing works

Akkermansia muciniphila and herbal medicine in immune-related diseases: current evidence and future perspectives

Ding, X., Meng, P., Ma, X., Yue, J.-Y., Li, L., & Xu, L. (2024) · Frontiers in Microbiomes · doi:10.3389/frmbi.2024.1276015 · Cited by 9 · see citing works

Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders

Zaongo, S. D., & Chen, Y. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002493 · Cited by 8 · see citing works

Camu Camu effects on microbial translocation and systemic immune activation in ART-treated people living with HIV: protocol of the single-arm non-randomised Camu Camu prebiotic pilot study (CIHR/CTN PT032)

Isnard, S., Fombuena, B., Ouyang, J., Royston, L., Lin, J. C.-Y., Bu, S., Sheehan, N. L., Lakatos, P. L., Bessissow, T., Chomont, N., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-053081 · Cited by 8 · see citing works

Translocation of bacterial LPS is associated with self-reported cognitive abilities in men living with HIV receiving antiretroviral therapy

Isnard, S., Royston, L., Scott, S. C., Mabanga, T., Lin, J. C.-Y., Fombuena, B., Bu, S., Berini, C. A., Goldberg, M. S., Finkelman, M., et al. (2023) · AIDS Research and Therapy · doi:10.1186/s12981-023-00525-z · Cited by 7 · see citing works

HIV and the gut microbiome: future research hotspots and trends

Wu, Z., Xie, Z.-P., Cui, X., Sun, X., Zhao, F., Wang, N., Li, Y., Wang, H., Zhang, L., Shen, J., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1466419 · Cited by 6 · see citing works

Metformin as adjunctive therapy in combination with multidrug treatment for multibacillary leprosy: A protocol for a randomized double-blind, controlled Phase 2 trial in Indonesia (MetLep Trial)

Krismawati, H., Muchtar, S. V., Rahardjani, M., Oktaviani, M., ., S., Imbiri, N., Hasvitasari, D. E., Fajrianti, D. R., Tarino, N., Wulandari, F., et al. (2023) · Wellcome Open Research · doi:10.12688/wellcomeopenres.19455.1 · Cited by 6 · see citing works

Metformin as adjunctive therapy in combination with multidrug treatment for multibacillary leprosy: A protocol for a randomized double-blind, controlled Phase 2 trial in Indonesia (MetLep Trial)

Krismawati, H., Muchtar, S. V., Rahardjani, M., Utami, N. N., Oktaviani, M., Puspatriani, K., ., S., Imbiri, N., Hasvitasari, D. E., Fajrianti, D. R., et al. (2024) · Wellcome Open Research · doi:10.12688/wellcomeopenres.19455.2 · Cited by 5 · see citing works

Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study

Royston, L., Isnard, S., Berini, C. A., Bu, S., Lakatos, P. L., Bessissow, T., Chomont, N., Klein, M. B., Lebouché, B., de Pokomandy, A., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-067640 · Cited by 5 · see citing works

Enteropathy and gut dysbiosis as obstacles to achieve immune recovery in undetectable people with HIV: a clinical view of evidence, successes, and projections

Castillo‐Rozas, G., López, M. N., Soto‐Rifo, R., Vidal, R. M., & Cortés, C. P. (2023) · AIDS · doi:10.1097/qad.0000000000003450 · Cited by 5 · see citing works

Type 2 diabetes in people living with HIV: epidemiology, mechanisms, sex differences and early-life determinants

Moreno-López, R., Lazaro-Martin, B., Díez, C., Navarro‐Gómez, M. L., & Tarancón‐Díez, L. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1734023 · Cited by 4 · see citing works

Distinct Gut Microbiota Signatures Are Associated with Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease in People with HIV

Righetti, R., Cinque, F., Lebouché, B., Ballesteros, L. R., Routy, J., Klein, M. B., Szabo, J., Cox, J., Falutz, J., Haraoui, L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178165 · Cited by 4 · see citing works

Plasma GDF-15 Levels Are Associated With HIV Reservoir Markers Independently of Inflammation in People With HIV on Antiretroviral Therapy

Isnard, S., Royston, L., Berini, C. A., Mabanga, T., Al‐Abdulmalek, A., Aiyana, O., Sun, L., Far, M. E., Pagliuzza, A., Planas, D., et al. (2026) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiag202 · Cited by 3 · see citing works

Metformin, Microbiota and Health

Paz, G. S., & Fernandes, J. (2022) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2022.00032 · Cited by 3 · see citing works

Interventions for Type 2 Diabetes reduction among older people living with HIV in Harare

Mhlanga, N. L., & Netangaheni, R. T. (2024) · South African Family Practice · doi:10.4102/safp.v66i1.5827 · Cited by 3 · see citing works

Elevated Plasma GDF-15 Levels Are Associated with Aging, Multimorbidity, and Tobacco Exposure in People with HIV

López‐López, A., Alonso-Domínguez, J., Martínez-Barros, I., Pérez‐González, A., Ocampo, A., Morano, L. E., Cruz, B. C., de Castro, N. M. L., Pardo, O. B., Pérez‐Olmeda, M., et al. (2026) · Infectious Diseases and Therapy · doi:10.1007/s40121-026-01302-x · Cited by 2 · see citing works

An army marches on its stomach: immunometabolic dysregulation in persons with HIV

Routy, J., & Isnard, S. (2023) · AIDS · doi:10.1097/qad.0000000000003558 · Cited by 2 · see citing works

HIV and Aging in the Era of ART and COVID-19: Symposium Overview

Montano, M. A., LANDAY, A. L., Perkins, M. M., Holstad, M. M., Pallikkuth, S., Pahwa, S. G., & Symposium, H. A. A. I. T. E. O. A. A. C.-1. I.-C. (2022) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002837 · Cited by 1 · see citing works

A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?

Abdalla, A. L., Guajardo-Contreras, G., & Mouland, A. J. (2024) · Viruses · doi:10.3390/v16020229 · Cited by 1 · see citing works

Flower power: Locking HIV in the gut with French lilac

Rohr, O. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103299 · Cited by 1 · see citing works

Extinguish the Fire: Anti-inflammatory Strategies for Over Immune Activation in Chronic HIV-1 Infection

Cao, W., & Li, T. (2021) · Infectious Diseases & Immunity · doi:10.1097/id9.0000000000000013 · Cited by 1 · see citing works

Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4+ T-Cells by Decreasing Viral ReleasePreprint

Fert, A., Richard, J., Marchand, L. R., Planas, D., Routy, J., Chomont, N., Finzi, A., & Ancuța, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.15.580166 · Cited by 1 · see citing works

Metformin Treatment and Immune Reconstitution in People With HIV and Type 2 Diabetes: A Matched Retrospective Study

Bäckdahl, T., Hedberg, P., Vesterbacka, J., Carlander, C., Sönnerborg, A. B., & Nowak, P. (2025) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaf110

Metformin for endothelial dysfunction in non-diabetic disorders: a scoping review

van Rensburg, R., Schoonees, A., Ali, M. W., van Zyl, G. U., & Decloedt, E. H. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-100017

Additional file 1 of Translocation of bacterial LPS is associated with self-reported cognitive abilities in men living with HIV receiving antiretroviral therapy

Isnard, S., Royston, L., Scott, S. C., Mabanga, T., Lin, J., Fombuena, B., Bu, S., Berini, C. A., Goldberg, M. S., Finkelman, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26590221

MiR-296-3p in Follicular Fluidderived Extracellular Vesicles Ameliorates the Ovarian Granulosa Cell Inflammatory Stress Response in Polycystic Ovary Syndrome

Bi, X., Zhu, P., Su, D., Wu, X., & Li, L. E. (2026) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x424112251203174621

La metformine en prévention de l’hyperémèse gravidique : du rationnel en lien avec GDF-15 aux premières données cliniques

Deruelle, P., Arcieri, F., & Martineau, R. (2026) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2026.06.002

Metformin and Weight Changes in Non-diabetic Older People With HIV (METFORAGING): A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial

Marcelo, C., Esteban-Cantos, A., Jurado, F., Montejano, R., Gutiérrez-García, L., Grela, A. D. G., Martínez-Martín, P., Vidal, A. D., Buckley, R. D. M., López, C. M. O., et al. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag489

Abstract PR04: Potential of metformin to modify the gut microbiota and prevent inflammation in nondiabetic people with HIV

Isnard, S., Lin, J. C.-Y., Frombuena, B., Varin, T. V., Marette, A., Planas, D., Messaoudene, M., Routy, B., van der Ley, C., Kema, I. P., et al. (2020) · Cancer Research · doi:10.1158/1538-7445.mvc2020-pr04

Metformin and Weight Changes in Non-diabetic Older People With HIV (METFORAGING): A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial

Marcelo, C., Esteban-Cantos, A., Jurado, F., Montejano, R., Gutiérrez-García, L., Grela, A. D. G., Martínez-Martín, P., Vidal, A. D., Buckley, R. D. M., López, C. M. O., et al. (2026) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofag489

Metformin effect on gut microbiota: insights for HIV-related inflammation

Ouyang, J., Isnard, S., Lin, J. C.-Y., Fombuena, B., Marette, A., Routy, B., Chen, Y., & Routy, J. (2020) · AIDS Research and Therapy · doi:10.1186/s12981-020-00267-2 · Cited by 58 · see citing works

Sustained gut dysbiosis and intestinal inflammation show correlation with weight gain in person with chronic HIV infection on antiretroviral therapy

Ishizaka, A., Koga, M., Mizutani, T., Suzuki, Y., Matano, T., & Yotsuyanagi, H. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03431-0 · Cited by 10 · see citing works

Potential of metformin to modify the gut microbiota and prevent inflammation in nondiabetic people with HIV.

Isnard, S., Lin, J., Frombuena, B., Varin, T. V., Marette, A., Planas, D., Messaoudene, M., Routy, B., Van der Ley, C., Kema, I., et al. (2020) · University of Groningen research database (University of Groningen / Centre for Information Technology)