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Cited by 56Diabetes, Cardiovascular Risks, and LipoproteinsWorkplace Health and Well-beingDiabetes Management and Research

Psychosocial factors are independent risk factors for the development of Type 2 diabetes in Japanese workers with impaired fasting glucose and/or impaired glucose tolerance1

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Toshihiro, M., Saito, K., Takikawa, S., Takebe, N., Onoda, T., Satoh, J.·2008·Diabetic Medicine
DOI 10.1111/j.1464-5491.2008.02566.xPMC PMC2701561
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Abstract

Aims We prospectively studied Japanese workers with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) and analysed possible risk factors for diabetes, including psychosocial factors such as stress. Methods The participants were 128 male Japanese company employees (mean age, 49.3 ± 5.9 years) with IFG and/or IGT diagnosed by oral glucose tolerance test (OGTT). Participants were prospectively studied for 5 years with annual OGTTs. The Kaplan–Meier method and Cox's proportional hazard model were used to analyse the incidence of diabetes and the factors affecting glucose tolerance, including anthropometric, biochemical and social–psychological factors. Results Of 128 participants, 36 (28.1%) developed diabetes and 39 (30.5%) returned to normal glucose tolerance (NGT) during a mean follow‐up of 3.2 years. Independent risk factors for diabetes were night duty [hazard ratio (HR) = 5.48, P = 0.002], higher fasting plasma glucose (FPG) levels within 6.1–6.9 mmol/l (HR = 1.05, P = 0.031), stress (HR = 3.81, P = 0.037) and administrative position (HR = 12.70, P = 0.045), while independent factors associated with recovery were lower FPG levels (HR = 0.94, P = 0.017), being a white‐collar worker (HR = 0.34, P = 0.033), non‐smoking (HR = 0.31, P = 0.040) and lower serum alanine aminotransferase (ALT) levels (HR = 0.97, P = 0.042). Conclusions In addition to FPG levels at baseline, psychosocial factors (night duty, stress and administrative position) are risk factors for Type 2 diabetes, while being a white‐collar worker, a non‐smoker and lower serum ALT levels are factors associated with return to NGT in Japanese workers with IFG and/or IGT.

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  • The association between perceived stress and T2DM varies by sex or socioeconomic status in some studies.

    “However, this association has been shown in some studies to vary by sex or socioeconomic status (as measured by occupational status), which indicates that these factors might moderate this relationship.”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [82]

    The Discussion (page unavailable) identifies stress in daily life and administrative position as separate risk factors for progression to Type 2 diabetes in Japanese workers with impaired glucose regulation. It does not show that the stress–diabetes association varies by occupational status or sex, so the proposed moderation is unsupported. (LLM, conf=0.84)

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  • In Japanese men (n=128; mean follow-up 3.2 years), perceived stress using a 15-item stress in daily life questionnaire developed for Japanese individuals was associated with incident diabetes mellitus (baseline OR 2.07, 95% CI 1.19-3.62; HR 3.81, 95% CI 1.09-13.35).

    “Japanese men ( n = 128; mean follow-up 3.2 years) | Perceived stress using 15- item stress in daily life questionnaire developed for Japanese individuals | baseline OR 2.07 (95% CI 1.19- 3.62). *HR 3.81 (95% CI 1.09-13.35).”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Toshihiro (2008) 75

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  • A link exists between perceived stress and development of T2DM.

    “Considering the evidence as a whole, a link seems to exist between perceived stress and development of T2DM.”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [82]

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Authors
Toshihiro, M., Saito, K., Takikawa, S., Takebe, N., Onoda, T., & Satoh, J.
Affiliations
Iwate Medical University (JP)
Corresponding author
Satoh, J.
ORCID
Venue
Diabetic Medicine
Publisher
Wiley
Published
2008-10
Volume
25
Issue
10
Pages
1211-1217
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
DOI
10.1111/j.1464-5491.2008.02566.x
PMC
PMC2701561
OpenAlex
W1975543533
Cited by
56
References
3
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 3
FWCI
1.69
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Diabetic Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology (2004-2008)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes, impaired fasting glucose, impaired glucose tolerance, psychosocial risk factors, occupational stress, night shift work, administrative positions, white-collar workers, smoking, serum alanine aminotransferase, fasting blood glucose, Japanese workers
MeSH terms
Adult, Diabetes Mellitus, Type 2, Humans, Life Style, Male, Middle Aged, Prediabetic State, Prospective Studies, Psychology, Risk Factors, Smoking, Stress, Psychological, Multivariate Analysis, Chi-Square Distribution, Glucose Intolerance, Disease Progression

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