Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption
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Sleep deficiency and out-of-synch circadian rhythms impair pancreatic insulin secretion, a possible precursor to metabolic syndrome and diabetes.
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Studies examining resting metabolic rate using indirect calorimetry found either no difference or a lower resting metabolic rate with sleep restriction relative to habitual sleep.
“Studies that have examined the impact of sleep duration on resting metabolic rate using indirect calorimetry have found either no difference57,62,79–81 or a lower resting metabolic rate69 with sleep restriction relative to habitual sleep.”
From Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association (2016) · cites this paper as [69]
In humans, transient misalignment of behaviors and the circadian clock increases inflammation and impairs glucose regulation, with potential relevance to cardiovascular disease.
“In humans, transient misalignment of behaviors and the circadian clock increases inflammation and impairs glucose regulation (137-140), with potential relevance to CV disease (141).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [137]
A history of 3 weeks of circadian misalignment plus sleep restriction caused a decrease in glucose tolerance and a decrease in insulin release, with recovery after a week of sleep extension.
“A second study showed that a history of 3 wk of circadian misalignment plus sleep restriction caused a decrease in glucose tolerance and a decrease in insulin release, with recovery after a week of sleep extension (70).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [70]
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- Authors
- Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Buxton, Orfeu M.
- Venue
- Science Translational Medicine
- Published
- 2012-04-11
- Volume
- 4
- Issue
- 129
- Pages
- 129ra43-129ra43
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3678519
- OpenAlex
- W2159185691
- Cited by
- 932
- References
- 49
- Citations by year
- 2026: 23 · 2025: 50 · 2024: 42 · 2023: 41 · 2022: 65 · 2021: 75 · 2020: 82 · 2019: 75 · 2018: 83 · 2017: 70 · 2016: 88 · 2015: 89 · 2014: 72 · 2013: 59 · 2012: 17
- FWCI
- 101.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01AG009975)
- National Heart, Lung, and Blood Institute (K24-HL76446, K24HL076446, R01HL107240)
- National Institute of Diabetes and Digestive and Kidney Diseases (5 P30 DK-36836, P30DK036836)
- National Center for Research Resources (M01 RR 02635, UL1RR025758, M01RR002635)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep restriction, circadian rhythm disruption, glucose regulation, insulin secretion, resting metabolic rate, postprandial blood glucose, metabolic syndrome, diabetes risk, obesity, shift work, recovery sleep
- MeSH terms
- Adult, Aged, Blood Glucose, Female, Humans, Male, Middle Aged, Linear Models, Sleep Disorders, Circadian Rhythm, Metabolic Syndrome, Young Adult
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