Effect of psychological stress on glucose control in patients with Type 2 diabetes
Open accessAbstract
AIM: To investigate the effect of acute psychological stress on glucose concentrations in patients with Type 2 diabetes, in the fasting state as well as in the postprandial state. METHODS: Thirty patients (12 female) with Type 2 diabetes were included. Mean ± SD age was 60 ± 12 years, BMI 28.8 ± 4.2 kg/m(2), diabetes duration 8.9 ± 6.7 years and HbA(1c) 51 ± 9 mmol/mol (6.8 ± 0.8%). Using a non-randomized approach, all participants were exposed to moderate psychological stress by means of the Trier Social Stress Test: 10 participants in the fasting state and 20 participants 75 min after intake of a standard meal. Blood pressure, heart rate and salivary cortisol were monitored on the control day and the stress-test day. Glucose concentrations were assessed using a continuous glucose monitoring system. RESULTS: On the stress-test day, blood pressure rose from 117/73 ± 13/12 to 155/92 ± 22/14 mmHg, heart rate from 77 ± 11 to 91 ± 25 b min(-1) and salivary cortisol concentrations from 8.5 ± 3.7 to 26.4 ± 12.1 nmol/l (P < 0.001); these measurements remained unchanged on the control day. On the stress-test day, when the Trier Social Stress Test was applied 75 min after the intake of a standard meal, the glucose concentrations were significantly higher compared with the control day (mean difference 1.5 mmol/l, 95% CI 0.5-2.4, P = 0.003). In the fasting state, glucose concentrations slightly decreased during the control day but remained stable on the stress-test day (mean difference compared with the control day 0.7 mmol/l, 95% CI -0.7 to 2.0, P = 0.31). CONCLUSIONS: When stress is experienced in the postprandial period, acute psychological stress significantly increases glucose concentrations in patients with Type 2 diabetes.
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Stress affects glucose levels and increases glucose variability in patients with type 1 and type 2 diabetes.
“stress affects glucose levels and increased glucose variability in both patients with type 1 and 2 diabetes”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Faulenbach et al., 2012
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Picard, M., McManus, M. J., Gray, J. D., Nasca, C., Moffat, C., Kopinski, P. K., Seifert, E. L., McEwen, B. S., & Wallace, D. C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515733112 · Cited by 293 · see citing works
Role of addiction and stress neurobiology on food intake and obesity
Sinha, R. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2017.05.001 · Cited by 211 · see citing works
Khera, A., Baum, S. J., Gluckman, T. J., Gulati, M., Martin, S. S., Michos, E. D., Navar, A. M., Taub, P. R., Toth, P. P., Virani, S. S., et al. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100009 · Cited by 143 · see citing works
- Authors
- Faulenbach, M., Uthoff, H., Schwegler, K., Spinas, G. A., Schmid, C., & Wiesli, P.
- Affiliations
- University Hospital Zurich (CH)
- University Hospital of Basel (CH)
- Kantonsspital Frauenfeld (CH)
- Corresponding author
- Wiesli, P.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2011-12-07
- Volume
- 29
- Issue
- 1
- Pages
- 128-131
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2148056958
- Cited by
- 96
- References
- 6
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- type 2 diabetes, acute psychological stress, glycemic control, postprandial blood glucose, fasting blood glucose, Trier Social Stress Test, salivary cortisol, blood pressure, heart rate, continuous glucose monitoring
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Female, Humans, Hydrocortisone, Male, Middle Aged, Psychological Tests, Saliva, Stress, Psychological, Biomarkers, Body Mass Index, Blood Pressure Monitoring, Ambulatory, Postprandial Period
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