The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Low‐carbohydrate diets: nutritional and physiological aspects
Abstract
Summary: Recently, diets low in carbohydrate content have become a matter of international attention because of the WHO recommendations to reduce the overall consumption of sugars and rapidly digestible starches. One of the common metabolic changes assumed to take place when a person follows a low‐carbohydrate diet is ketosis. Low‐carbohydrate intakes result in a reduction of the circulating insulin level, which promotes high level of circulating fatty acids, used for oxidation and production of ketone bodies. It is assumed that when carbohydrate availability is reduced in short term to a significant amount, the body will be stimulated to maximize fat oxidation for energy needs. The currently available scientific literature shows that low‐carbohydrate diets acutely induce a number of favourable effects, such as a rapid weight loss, decrease of fasting glucose and insulin levels, reduction of circulating triglyceride levels and improvement of blood pressure. On the other hand some less desirable immediate effects such as enhanced lean body mass loss, increased urinary calcium loss, increased plasma homocysteine levels, increased low‐density lipoprotein‐cholesterol have been reported. The long‐term effect of the combination of these changes is at present not known. The role of prolonged elevated fat consumption along with low‐carbohydrate diets should be addressed. However, these undesirable effects may be counteracted with consumption of a low‐carbohydrate, high‐protein, low‐fat diet, because this type of diet has been shown to induce favourable effects on feelings of satiety and hunger, help preserve lean body mass, effectively reduce fat mass and beneficially impact on insulin sensitivity and on blood lipid status while supplying sufficient calcium for bone mass maintenance. The latter findings support the need to do more research on this type of hypocaloric low‐carbohydrate diet.
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Citations
Cites
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
A Randomized Trial of a Low-Carbohydrate Diet for Obesity
Foster, G. D., Wyatt, H. R., Hill, J. O., McGuckin, B. G., Brill, C., Mohammed, B. S., Szapary, P. O., Rader, D. J., Edman, J. S., & Klein, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022207 · Cited by 1,794
A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity
Samaha, F. F., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, T., Williams, M., Gracely, E. J., & Stern, L. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022637 · Cited by 1,267 · cited 2×
“obesity reviews 7 , 49–58 consumption of low-CHO, high-fat diets, especially in diabetic subjects (6,12).”
BackgroundStern, L., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, M., Gracely, E. J., & Samaha, F. F. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-10-200405180-00007 · Cited by 831 · cited 1×
“However, after 1 year of dieting, the level of weight loss in individuals who followed either a high-CHO or a lowCHO diet is similar (7,17).”
BackgroundBrehm, B. J., Seeley, R. J., Daniels, S. R., & D’Alessio, D. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021480 · Cited by 830
Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM
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“In this respect, it needs to be pointed out that low-CHO, high-protein diets do not seem to impact as severely circulating free fatty acids levels as low-CHO, high-fat diets (43,44).”
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Cited by
Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941
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Kirkpatrick, C. F., Bolick, J. P., Kris-Etherton, P. M., Sikand, G., Aspry, K. E., Soffer, D. E., Willard, K.-E., & Maki, K. C. (2019) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2019.08.003 · Cited by 390
Do ketogenic diets really suppress appetite? A systematic review and meta‐analysis
Gibson, A. A., Seimon, R. V., Lee, C. M. Y., Ayre, J., Franklin, J., Markovic, T. P., Caterson, I. D., & Sainsbury, A. (2015) · Obesity Reviews · doi:10.1111/obr.12230 · Cited by 366
Dietary interventions for obesity: clinical and mechanistic findings.
Chao, A. M., Quigley, K. M., & Wadden, T. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140065 · Cited by 257
Metadata
- Authors
- Adam‐Perrot, A., Clifton, P., & Brouns, F.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2006-01-24
- Volume
- 7
- Issue
- 1
- Pages
- 49-58
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W2105690412
- Cited by
- 248
- References
- 13
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
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