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Cited by 353Nutritional Studies and DietAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

Fruit, Vegetable, and Antioxidant Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality in a Community-dwelling Population in Washington County, Maryland

Genkinger, J. M., Platz, E. A., Hoffman, S. C., Comstock, G. W., Helzlsouer, K. J.·2004·American Journal of Epidemiology
DOI 10.1093/aje/kwh339
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Abstract

Higher intake of fruits, vegetables, and antioxidants may help protect against oxidative damage, thus lowering cancer and cardiovascular disease risk. This Washington County, Maryland, prospective study examined the association of fruit, vegetable, and antioxidant intake with all-cause, cancer, and cardiovascular disease death. CLUE participants who donated a blood sample in 1974 and 1989 and completed a food frequency questionnaire in 1989 (N = 6,151) were included in the analysis. Participants were followed to date of death or January 1, 2002. Compared with those in the bottom fifth, participants in the highest fifth of fruit and vegetable intake had a lower risk of all-cause (cases = 910; hazard ratio (HR) = 0.63, 95% confidence interval (CI): 0.51, 0.78; p-trend = 0.0004), cancer (cases = 307; HR = 0.65, 95% CI: 0.45, 0.93; p-trend = 0.08), and cardiovascular disease (cases = 225; HR = 0.76, 95% CI: 0.54, 1.06; p-trend = 0.15) mortality. Higher intake of cruciferous vegetables was associated with lower risk of all-cause mortality (HR = 0.74, 95% CI: 0.60, 0.91; p-trend = 0.04). No statistically significant associations were observed between dietary vitamin C, vitamin E, and beta-carotene intake and mortality. Overall, greater intake of fruits and vegetables was associated with lower risk of all-cause, cancer, and cardiovascular disease death. These findings support the general health recommendation to consume multiple servings of fruits and vegetables (5-9/day).

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  • A diet enriched with fruits and vegetables or antioxidants in the form of supplements lowered the risk of incidence and mortality in patients suffering from cancer.

    “A diet enriched with fruits and vegetables or antioxidants in the form of supplements lowered the risk of incidence and mortality in patients suffering from cancer (Genkinger et al. 2004).”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Genkinger et al. 2004

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Authors
Genkinger, J. M., Platz, E. A., Hoffman, S. C., Comstock, G. W., & Helzlsouer, K. J.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2004-12-06
Volume
160
Issue
12
Pages
1223-1233
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/kwh339
OpenAlex
W2122872164
Cited by
351
References
48
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 22 · 2020: 10 · 2019: 18 · 2018: 12 · 2017: 20 · 2016: 22 · 2015: 21 · 2014: 23 · 2013: 27 · 2012: 20
FWCI
13.58
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense
  • New York City Department of Health and Mental Hygiene
  • National Institute on Aging (U01AG018033, 1U01AG18033)
  • National Heart, Lung, and Blood Institute (K06HL021670, HL 21670)
  • National Cancer Institute (1U01 CA 86308, U01CA086308)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
fruit and vegetable intake, antioxidant intake, dietary antioxidants, cancer mortality, cardiovascular mortality, all-cause mortality, cruciferous vegetables, vitamin C, vitamin E, beta-carotene, dietary recommendations, Washington County, Maryland
MeSH terms
Adult, Aged, Aged, 80 and over, Antioxidants, Ascorbic Acid, Cardiovascular Diseases, Cause of Death, Diet, Female, Fruit, Humans, Male, Maryland, Middle Aged, Neoplasms, Smoking, Vegetables, Cohort Studies, Body Mass Index, beta Carotene, alpha-Tocopherol

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