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The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes
Abstract
Uncoupling proteins (UCPs) belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. In mammals, more than five family members have been identified, including UCP1, UCP2, UCP3, UCP4 (or BMCP1/UCP5) and UCP5. The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.
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“Polymorphisms in UCP2 and UCP3 affect mitochondrial efficiency, influencing the degree of energy dissipated as heat, and thus, the overall rate of fat oxidation [72].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [72]
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Metadata
- Authors
- Jia, J. ‐., Zhang, X., Ge, C. ‐., & Jois, M.
- Affiliations
- Yunnan Agricultural University (CN)
- La Trobe University (AU)
- ORCID
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2009-08-26
- Volume
- 10
- Issue
- 5
- Pages
- 519-526
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W2159844679
- Cited by
- 137
- References
- 67
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 5 · 2016: 4 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 7
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- uncoupling proteins, UCP2, UCP3, genetic polymorphism, fat metabolism, obesity, diabetes mellitus, insulin resistance, energy homeostasis, thermogenesis, mitochondrial uncoupling, genetic association
- MeSH terms
- Uncoupling Protein 2, Uncoupling Protein 3, Diabetes Mellitus, Exons, Haplotypes, Humans, Ion Channels, Obesity, Promoter Regions, Genetic, 3' Untranslated Regions, Polymorphism, Single Nucleotide, Mitochondrial Proteins, Lipid Metabolism, INDEL Mutation
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