Cited by 74Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases: Brain-specific fatty acid-binding protein in dementia

Teunissen, C. E., Veerhuis, R., De Vente, J., Verhey, F. R. J., Vreeling, F., van Boxtel, M. P. J., Glatz, J. F. C., Pelsers, M. A. L.·2011·European Journal of Neurology

Abstract

BACKGROUND: There is a need for biomarkers in accessible matrices, such as blood, for the diagnosis of neurodegenerative diseases. The aim of this study was to measure the serum levels of brain-type fatty acid-binding protein (FABP) and heart-type FABP in patients with dementia-involving diseases. METHODS: Brain- and heart-type FABP were measured in serum samples from patients with either Alzheimer's disease (AD) (n = 31), Parkinson's disease (PD, n = 43), or other cognitive disorders (OCD, n = 42) and in 52 healthy controls. The localization of brain- and heart-type FABP was determined in brain sections by immunohistochemistry. RESULTS: Brain-type FABP levels were elevated in serum of 29%, 35%, and 24% of the patients with AD, PD, and OCD, respectively, and in 2% of the healthy donors. Heart-type FABP serum levels were not different amongst the patient groups. Brain-type and heart-type FABP expression was observed in reactive astrocytes in brain sections of patients with AD. CONCLUSIONS: In contrast to heart-type FABP, serum levels of brain-type FABP are elevated in a significant proportion of patients with various neurodegenerative diseases and can therefore have importance for defining subgroups of these patients.

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Crossref · 10.1111/j.1468-1331.2010.03273.x

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Authors
Teunissen, C. E., Veerhuis, R., De Vente, J., Verhey, F. R. J., Vreeling, F., van Boxtel, M. P. J., Glatz, J. F. C., & Pelsers, M. A. L.
Affiliations
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
  • Maastricht University Medical Centre (NL)
  • Maastricht University (NL)
Corresponding author
Teunissen, C. E.
Venue
European Journal of Neurology
Publisher
Wiley
Published
2010-12-08
Volume
18
Issue
6
Pages
865-871
ISSN
1351-5101 (ISSN-L)
OpenAlex
W2166665456
Cited by
74
References
35
Citations by year
2026: 1 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 3 · 2012: 1
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
heart-type fatty acid-binding protein, serum biomarkers, dementia, Alzheimer's disease, Parkinson's disease, cognitive disorders, neurodegenerative diseases, reactive astrocytes, blood-based diagnosis
MeSH terms
Fatty Acid-Binding Protein 7, Fatty Acid Binding Protein 3, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Carrier Proteins, Cognition Disorders, Dementia, Female, Humans, Male, Middle Aged, Parkinson Disease, Biomarkers, Up-Regulation, Tumor Suppressor Proteins, Fatty Acid-Binding Proteins

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