Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases: Brain-specific fatty acid-binding protein in dementia
Abstract
BACKGROUND: There is a need for biomarkers in accessible matrices, such as blood, for the diagnosis of neurodegenerative diseases. The aim of this study was to measure the serum levels of brain-type fatty acid-binding protein (FABP) and heart-type FABP in patients with dementia-involving diseases. METHODS: Brain- and heart-type FABP were measured in serum samples from patients with either Alzheimer's disease (AD) (n = 31), Parkinson's disease (PD, n = 43), or other cognitive disorders (OCD, n = 42) and in 52 healthy controls. The localization of brain- and heart-type FABP was determined in brain sections by immunohistochemistry. RESULTS: Brain-type FABP levels were elevated in serum of 29%, 35%, and 24% of the patients with AD, PD, and OCD, respectively, and in 2% of the healthy donors. Heart-type FABP serum levels were not different amongst the patient groups. Brain-type and heart-type FABP expression was observed in reactive astrocytes in brain sections of patients with AD. CONCLUSIONS: In contrast to heart-type FABP, serum levels of brain-type FABP are elevated in a significant proportion of patients with various neurodegenerative diseases and can therefore have importance for defining subgroups of these patients.
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Serum FABP3 level is increased in PD.
“Intriguingly, serum FABP3 level is increased in PD [152].”
From Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia (2020) · cites this paper as [152]
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- Authors
- Teunissen, C. E., Veerhuis, R., De Vente, J., Verhey, F. R. J., Vreeling, F., van Boxtel, M. P. J., Glatz, J. F. C., & Pelsers, M. A. L.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Corresponding author
- Teunissen, C. E.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2010-12-08
- Volume
- 18
- Issue
- 6
- Pages
- 865-871
- ISSN
- 1351-5101 (ISSN-L)
- OpenAlex
- W2166665456
- Cited by
- 74
- References
- 35
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 3 · 2012: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- heart-type fatty acid-binding protein, serum biomarkers, dementia, Alzheimer's disease, Parkinson's disease, cognitive disorders, neurodegenerative diseases, reactive astrocytes, blood-based diagnosis
- MeSH terms
- Fatty Acid-Binding Protein 7, Fatty Acid Binding Protein 3, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Carrier Proteins, Cognition Disorders, Dementia, Female, Humans, Male, Middle Aged, Parkinson Disease, Biomarkers, Up-Regulation, Tumor Suppressor Proteins, Fatty Acid-Binding Proteins
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