Amyloid‐β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila
Open accessAbstract
Disruption of sleep/wake activity in Alzheimer's disease (AD) patients significantly affects their quality of life and that of their caretakers and is a major contributing factor for institutionalization. Levels of amyloid-β (Aβ) have been shown to be regulated by neuronal activity and to correlate with the sleep/wake cycle. Whether consolidated sleep can be disrupted by Aβ alone is not well understood. We hypothesize that Aβ42 can increase wakefulness and disrupt consolidated sleep. Here we report that flies expressing the human Aβ42 transgene in neurons have significantly reduced consolidated sleep compared with control flies. Fatty acid binding proteins (Fabp) are small hydrophobic ligand carriers that have been clinically implicated in AD. Aβ42 flies that carry a transgene of either the Drosophila Fabp or the mammalian brain-type Fabp show a significant increase in nighttime sleep and long consolidated sleep bouts, rescuing the Aβ42-induced sleep disruption. These studies suggest that alterations in Fabp levels and/or activity may be associated with sleep disturbances in AD. Future work to determine the molecular mechanisms that contribute to Fabp-mediated rescue of Aβ42-induced sleep loss will be important for the development of therapeutics in the treatment of AD. © 2016 Wiley Periodicals, Inc.
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Sleep is an emergent set of many physiologic processes under primarily neurobiological regulation that impact many physiologic systems.
“Sleep represents an emergent set of many physiologic processes under primarily neurobiological regulation that impact many physiologic systems.”
From Sleep, Health, and Society (2017) · cites this paper as [7]
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RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · cited 1× · see citing works
“Ab accumulation is also believed to cause cognitive deficits across these species (Iijima et al., 2004; Lesne et al., 2006, 2013; Kittelberger et al., 2012).”
BackgroundRetractedAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works
Alzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works
Fagan, A. M., Mintun, M. A., Mach, R. H., Lee, S., Dence, C. S., Shah, A. R., LaRossa, G. N., Spinner, M. L., Klunk, W. E., Mathis, C. A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20730 · Cited by 1,246 · see citing works
Sperling, R. A., LaViolette, P. S., O'Keefe, K., O'Brien, J., Rentz, D. M., Pihlajamaki, M., Marshall, G., Hyman, B. T., Selkoe, D. J., Hedden, T., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.003 · Cited by 1,027 · see citing works
Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 999 · see citing works
Sleep and Alzheimer disease pathology--a bidirectional relationship
Ju, Y.-E. S., Lucey, B. P., & Holtzman, D. M. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.269 · Cited by 996 · see citing works
A conditional tissue-specific transgene expression system using inducible GAL4
Osterwalder, T., Yoon, K. S., White, B. H., & Keshishian, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221303298 · Cited by 770 · see citing works
Sleep Quality and Preclinical Alzheimer Disease
Ju, Y.-E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C., & Holtzman, D. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2334 · Cited by 744 · see citing works
PET imaging of amyloid deposition in patients with mild cognitive impairment
Forsberg, A., Engler, H., Almkvist, O., Blomquist, G., Hagman, G., Wall, A. E., Ringheim, A., Långström, B., & Nordberg, A. K. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.029 · Cited by 725 · see citing works
Sheline, Y. I., Raichle, M. E., Snyder, A. Z., Morris, J. C., Head, D., Wang, S., & Mintun, M. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.024 · Cited by 597 · see citing works
Self-reported sleep and β-amyloid deposition in community-dwelling older adults
Spira, A. P., Gamaldo, A. A., An, Y., Wu, M. N., Simonsick, E. M., Bilgel, M., Zhou, Y., Wong, D. F., Ferrucci, L., & Resnick, S. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4258 · Cited by 570 · see citing works
Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004291 · Cited by 563 · see citing works
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
Abel, T. G., Havekes, R., Saletin, J., & Walker, M. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.025 · Cited by 551 · see citing works
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
Mander, B. A., Marks, S. M., Vogel, J. W., Rao, V. R., Lu, B. S., Saletin, J., Ancoli‐Israel, S., Jagust, W. J., & Walker, M. P. (2015) · Nature Neuroscience · doi:10.1038/nn.4035 · Cited by 546 · see citing works
Iijima, K., Liu, H., Chiang, A., Hearn, S., Konsolaki, M., & Zhong, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400895101 · Cited by 477 · see citing works
Sleep-disordered breathing advances cognitive decline in the elderly
Osorio, R. S., Gumb, T., Pirraglia, E., Varga, A. W., Lu, S., Lim, J. W. J., Wohlleber, M. E., Ducca, E. L., Koushyk, V., Glodzik, L., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001566 · Cited by 428 · see citing works
Drosophila as a Model for Human Neurodegenerative Disease
Bilen, J., & Bonini, N. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095804 · Cited by 420 · see citing works
McDermott, C. M., LaHoste, G. J., Chen, C., Musto, A., Bazan, N. G., & Magee, J. C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09687.2003 · Cited by 407 · see citing works
Brain amyloid-β oligomers in ageing and Alzheimer’s disease
Lesné, S., Sherman, M. A., Grant, M. K. O., Kuskowski, M. A., Schneider, J. A., Bennett, D. A., & Ashe, K. H. (2013) · Brain · doi:10.1093/brain/awt062 · Cited by 407 · see citing works
P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster
Roman, G., Endo, K., Zong, L., & Davis, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221303998 · Cited by 406 · see citing works
Circadian rhythms, sleep deprivation, and human performance
Goel, N., Basner, M., Rao, H., & Dinges, D. F. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00007-5 · Cited by 400 · cited 1× · see citing works
“Disturbances in sleep across many species, including flies, mice, and humans, have been shown to cause cognitive impairment and memory deficits (Graves et al., 2001; McDermott et al., 2003; Ganguly-Fitzgerald et al., 2006; Abel et al., 2013; Goel et al., 2013).”
BackgroundSleep Problems and Institutionalization of the Elderly
Pollak, C. P., & PERLICK, D. A. (1991) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879100400405 · Cited by 396 · see citing works
Genome-Wide Expression Analysis inDrosophilaReveals Genes Controlling Circadian Behavior
Ceriani, M. F., Hogenesch, J. B., Yanovsky, M. J., Panda, S., Straume, M., & Kay, S. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09305.2002 · Cited by 358 · see citing works
Mandrekar-Colucci, S., Karlo, J. C., & Landreth, G. E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5268-11.2012 · Cited by 355 · cited 2× · see citing works
“PPAR activation has been shown to facilitate the clearance of Ab in AD animal models (Mandrekar-Colucci et al., 2012; Yamanaka et al., 2012), and, because DHA triggers nuclear localization of Fabp7 to regulate PPAR-mediate transcription (Mita et al., 2010), this pathway may represent one mechanism…”
BackgroundOrexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease
Liguori, C., Romigi, A., Nuccetelli, M., Zannino, S., Sancesario, G., Martorana, A., Albanese, M., Mercuri, N. B., Izzi, F., Bernardini, S., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2510 · Cited by 355 · see citing works
A Drosophila model for age-associated changes in sleep:wake cycles
Koh, K., Evans, J. M., Hendricks, J. C., & Sehgal, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605903103 · Cited by 341 · see citing works
A dynamic role for the mushroom bodies in promoting sleep in Drosophila
Pitman, J. L., McGill, J. J., Keegan, K. P., & Allada, R. (2006) · Nature · doi:10.1038/nature04739 · Cited by 330 · see citing works
Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & Heneka, M. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-12.2012 · Cited by 326 · cited 2× · see citing works
“PPAR activation has been shown to facilitate the clearance of Ab in AD animal models (Mandrekar-Colucci et al., 2012; Yamanaka et al., 2012), and, because DHA triggers nuclear localization of Fabp7 to regulate PPAR-mediate transcription (Mita et al., 2010), this pathway may represent one mechanism…”
BackgroundSleep, EEG and mental function changes in senile dementia of the Alzheimer's type
Prinz, P. N., VITALIANO, P. P., Vitiello, M. V., Bokan, J. A., Raskind, M. A., Peskind, E. R., & Gerber, C. J. (1982) · Neurobiology of Aging · doi:10.1016/0197-4580(82)90024-0 · Cited by 324 · see citing works
Waking Experience Affects Sleep Need in Drosophila
Ganguly-Fitzgerald, I., Donlea, J. M., & Shaw, P. J. (2006) · Science · doi:10.1126/science.1130408 · Cited by 310 · see citing works
Calon, F., & Cole, G. M. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.019 · Cited by 291 · see citing works
A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster
Finelli, A. L., Kelkar, A., Song, H., Yang, H., & Konsolaki, M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.03.001 · Cited by 286 · see citing works
Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System
Huang, Y. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.235 · Cited by 281 · see citing works
Wu, Y., & Swaab, D. F. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.010 · Cited by 280 · see citing works
Sleep Disturbances in Patients with Alzheimer??s Disease
Vitiello, M. V., & Soo Borson, B. (2001) · CNS Drugs · doi:10.2165/00023210-200115100-00004 · Cited by 278 · see citing works
Grimmer, T., Riemenschneider, M., Förstl, H., Henriksen, G., Klunk, W. E., Mathis, C. A., Shiga, T., Wester, H.-J., Kurz, A., & Drzezga, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.027 · Cited by 278 · see citing works
Fluctuations of CSF amyloid-β levels: Implications for a diagnostic and therapeutic biomarker
Bateman, R. J., Wen, G., Morris, J. C., & Holtzman, D. M. (2007) · Neurology · doi:10.1212/01.wnl.0000256043.50901.e3 · Cited by 260 · see citing works
Drosophila Models of Neurodegenerative Diseases
Lu, B., & Vogel, H. S. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.3.121806.151529 · Cited by 246 · see citing works
Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults
Sprecher, K. E., Bendlin, B. B., Racine, A. M., Okonkwo, O. C., Christian, B. T., Koscik, R. L., Sager, M. A., Asthana, S., Johnson, S. C., & Benca, R. M. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.004 · Cited by 243 · see citing works
Sleep and memory: a molecular perspective
Graves, L. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01744-6 · Cited by 216 · see citing works
Ligand Specificity of Brain Lipid-binding Protein
Xu, L. Z., Sánchez, R., Šali, A., & Heintz, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24711 · Cited by 206 · see citing works
Di Meco, A., Joshi, Y. B., & Praticò, D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.011 · Cited by 205 · see citing works
Novel CSF biomarkers for Alzheimer’s disease and mild cognitive impairment
Hu, W. T., Chen‐Plotkin, A. S., Arnold, S. E., Grossman, M., Clark, C. M., Shaw, L. M. J., Pickering, E. H., Kühn, M., Chen, Y., McCluskey, L. F., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0667-0 · Cited by 196 · see citing works
GREATER RISK OF ALZHEIMER'S DISEASE IN OLDER ADULTS WITH INSOMNIA
Osorio, R. S., Pirraglia, E., Agüera-Ortíz, L., During, E., Sacks, H., Ayappa, I. A., Walsleben, J. A., Mooney, A. M., Hussain, A., Glodzik, L., et al. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03288.x · Cited by 189 · see citing works
Pathological Tau Disrupts Ongoing Network Activity
Menkes-Caspi, N., Yamin, H. G., Kellner, V., Spires-Jones, T. L., Cohen, D., & Stern, E. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.025 · Cited by 184 · see citing works
Rothman, S. M., Herdener, N., Frankola, K. A., Mughal, M. R., & Mattson, M. P. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.010 · Cited by 172 · see citing works
Wisor, J. P., Edgar, D. M., Yesavage, J. A., Ryan, H. S., McCormick, C. M., Lapustea, N., & Murphy, G. M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.018 · Cited by 169 · see citing works
The sleep–wake Cycle and Alzheimer’s Disease: What do We know?
Lim, M. M., Gerstner, J. R., & Holtzman, D. M. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.33 · Cited by 168 · see citing works
Self-citationSleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability
Tabuchi, M., Lone, S. R., Liu, S., Liu, Q., Zhang, J., Spira, A. P., & Wu, M. N. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.016 · Cited by 165 · see citing works
Sleep Restores Behavioral Plasticity to Drosophila Mutants
Dissel, S., Angadi, V., Kirszenblat, L., Suzuki, Y., Donlea, J. M., Klose, M. K., Koch, Z., English, D., Winsky‐Sommerer, R., van Swinderen, B., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.027 · Cited by 150 · see citing works
Bennaars-Eiden, A., Higgins, L., Hertzel, A. V., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209493200 · Cited by 143 · see citing works
Nicholson, L. F. B., Singh, G. K., Osterwalder, T., Roman, G., Davis, R. L., & Keshishian, H. (2008) · Genetics · doi:10.1534/genetics.107.081968 · Cited by 138 · see citing works
Sleep and Wakefulness in Drosophila melanogaster
Cirelli, C., & Bushey, D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.017 · Cited by 124 · see citing works
Boudrault, C., Bazinet, R. P., & David, W. L. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.05.016 · Cited by 117 · see citing works
Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review
Weldemichael, D. A., & Grossberg, G. T. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/716453 · Cited by 114 · see citing works
Brain Fatty Acid-binding Protein and ω-3/ω-6 Fatty Acids
Mita, R., Beaulieu, M. J., Field, C. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.170076 · Cited by 113 · see citing works
Transgenic Drosophila models of Alzheimer’s disease and tauopathies
Iijima‐Ando, K., & Iijima, K. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0234-4 · Cited by 110 · see citing works
EEG, Activity, and Sleep Architecture in a Transgenic AβPPswe/PSEN1A246E Alzheimer's Disease Mouse
Jyoti, A., Plano, A., Riedel, G., & Platt, B. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100879 · Cited by 100 · see citing works
Sleep, aging, and lifespan in Drosophila
Bushey, D., Hughes, K. A., Tononi, G., & Cirelli, C. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-56 · Cited by 100 · see citing works
Zhang, B., Veasey, S. C., Wood, M. A., Leng, L. Z., Kaminski, C., Leight, S., Abel, T. G., Lee, V. M. ‐., & Trojanowski, J. Q. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61223-0 · Cited by 95 · see citing works
A Video Method to Study Drosophila Sleep
Zimmerman, J. E., Raizen, D. M., Maycock, M. H., Maislin, G., & Pack, A. I. (2008) · SLEEP · doi:10.1093/sleep/31.11.1587 · Cited by 94 · see citing works
Self-citationBiomarkers of Alzheimer's Disease Among Mexican Americans
O’Bryant, S. E., Xiao, G., Edwards, M., Devous, M. D., Gupta, V. B., Martins, R. N., Zhang, F., & Barber, R. C. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122074 · Cited by 80 · see citing works
Drosophila melanogaster: An Insect Model for Fundamental Studies of Sleep
Ho, K. S., & Sehgal, A. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93041-3 · Cited by 78 · see citing works
Mapping the Road Forward in Alzheimer’s Disease
Holtzman, D. M., Goate, A., Kelly, J. W., & Sperling, R. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3003529 · Cited by 77 · see citing works
Teunissen, C. E., Veerhuis, R., De Vente, J., Verhey, F. R. J., Vreeling, F., van Boxtel, M. P. J., Glatz, J. F. C., & Pelsers, M. A. L. (2011) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03273.x · Cited by 74 · see citing works
Fatty-Acid Binding Proteins Modulate Sleep and Enhance Long-Term Memory Consolidation in Drosophila
Gerstner, J. R., Vanderheyden, W. M., Shaw, P. J., Landry, C. F., & Yin, J. C. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015890 · Cited by 71 · see citing works
Self-citationChiasserini, D., Parnetti, L., Andréasson, U., Zetterberg, H., Giannandrea, D., Calabresi, P., & Blennow, K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101293 · Cited by 63 · see citing works
Guo, L., Alexopoulos, P., & Perneczky, R. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0405-4 · Cited by 62 · see citing works
Gerstner, J. R., Vanderheyden, W. M., LaVaute, T. M., Westmark, C. J., Rouhana, L., Pack, A. I., Wickens, M., & Landry, C. F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3228-11.2012 · Cited by 61 · see citing works
Self-citationHeart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration
Desikan, R. S., Thompson, W. K., Holland, D., Hess, C. P., Brewer, J. B., Zetterberg, H., Blennow, K., Andreassen, O. A., McEvoy, L. K., Hyman, B. T., et al. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-39 · Cited by 58 · see citing works
Cheon, M. S., Kim, S. H., Fountoulakis, M., & Lübec, G. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6721-2_20 · Cited by 53 · see citing works
Gerstner, J. R., Bremer, Q. Z., Heyden, W. M. V., LaVaute, T. M., Yin, J. C. P., & Landry, C. F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001631 · Cited by 52 · see citing works
Self-citationOlsson, B., Hertze, J., Ohlsson, M., Nägga, K., Höglund, K., Basun, H., Annas, P., Lannfelt, L., Andreasen, N., Minthon, L., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121384 · Cited by 46 · see citing works
ERK Phosphorylation Regulates Sleep and Plasticity in Drosophila
Vanderheyden, W. M., Gerstner, J. R., Tanenhaus, A. K., Yin, J. C. P., & Shaw, P. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081554 · Cited by 44 · see citing works
Self-citationChen, K., Possidente, B. P., Lomas, D. A., & Crowther, D. C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.014134 · Cited by 44 · see citing works
Lee, S., Lee, S. K., Paik, D., & Min, K. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/854502 · Cited by 39 · see citing works
Ageing Increases Vulnerability to Aβ42 Toxicity in Drosophila
Rogers, I., Kerr, F., Martinez, P., Hardy, J., Lovestone, S., & Partridge, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040569 · Cited by 38 · see citing works
Screening for New Biomarkers for Subcortical Vascular Dementia and Alzheimer’s Disease
Öhrfelt, A., Andréasson, U., Simon, A. J., Zetterberg, H., Edman, Å., Potter, W. Z., Holder, D., Devanarayan, V., Seeburger, J. L., Smith, A. D., et al. (2011) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000323417 · Cited by 37 · see citing works
Gerstner, J. R., Heyden, W. M. V., LaVaute, T. M., & Landry, C. F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.020 · Cited by 34 · see citing works
Self-citationHellberg, K., Grimsrud, P. A., Kruse, A. C., Banaszak, L. J., Ohlendorf, D. H., & Bernlohr, D. (2010) · Protein Science · doi:10.1002/pro.427 · Cited by 34 · see citing works
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Dyall, S. C. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/274128 · Cited by 26 · see citing works
Gerstner, J. R., Vanderheyden, W. M., Shaw, P. J., Landry, C. F., & Yin, J. C. P. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.16927 · Cited by 21 · see citing works
Self-citationThe Nexus of Aβ, Aging, and Sleep
Gerstner, J. R., Perron, I. J., & Pack, A. I. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004815 · Cited by 19 · see citing works
Self-citationReliability and variability of sleep and activity as biomarkers of ageing in Drosophila
Koudounas, S., Green, E. W., & Clancy, D. J. (2012) · Biogerontology · doi:10.1007/s10522-012-9393-4 · Cited by 13 · see citing works
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Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720 · see citing works
Circadian disruption and sleep disorders in neurodegeneration
Shen, Y., Lv, Q.-K., Xie, W.-Y., Gong, S.-Y., Zhuang, S., Liu, J.-Y., Mao, C.-J., & Liu, C.-F. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00340-6 · Cited by 171 · see citing works
Cleaning the sleeping brain – the potential restorative function of the glymphatic system
Hauglund, N. L., Pavan, C., & Nedergaard, M. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.10.020 · Cited by 129 · see citing works
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Yu, Y., Fedele, G., Celardo, I., Loh, S. H. Y., & Martins, L. M. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-03926-y · Cited by 46 · see citing works
- Authors
- Gerstner, J. R., Lenz, O., Vanderheyden, W. M., Chan, M. T., Pfeiffenberger, C., & Pack, A. I.
- Affiliations
- Washington State University Spokane (US)
- University of Pennsylvania (US)
- Corresponding author
- Gerstner, Jason R.
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2016-06-19
- Volume
- 95
- Issue
- 8
- Pages
- 1548-1564
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- PMC
- PMC5167666
- OpenAlex
- W2464960220
- Cited by
- 40
- References
- 91
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 2 · 2013: 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (T32 HL07713 (to J.R.G.), T32 HL110952 (to W.M.V.), P01AG017628 (to A.I.P.))
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- amyloid-beta, amyloid-beta 42, sleep fragmentation, fatty acid binding protein, Alzheimer's disease, sleep-wake cycle, Drosophila
- MeSH terms
- Animals, Disease Models, Animal, Drosophila, Gene Expression Regulation, Hormone Antagonists, Humans, Locomotion, RNA, Messenger, Sleep, Sleep Wake Disorders, Transcription Factors, Wakefulness, Mifepristone, Amyloid beta-Peptides, Drosophila Proteins, Animals, Genetically Modified, Fatty Acid-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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