The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Review Article: A new wrinkle on old skin: the role of elastic fibres in skin ageing
Open accessAbstract
Synopsis: Cutaneous ageing is the result of two distinct, biological processes which may occur concurrently: (i) the passage of time, termed intrinsic ageing and (ii) environmental influences, termed extrinsic ageing. Intrinsic ageing of the skin is a slow process which causes changes in tissue structure and impairs function in the absence of additional biological, chemical and physical factors. The clinical features of intrinsically aged skin are not usually evident until old age when, although smooth and unblemished, the skin surface appears pale and is characterized by fine wrinkles with occasional exaggerated expression lines. Functionally, intrinsically aged skin is dry and less elastic than more youthful skin. In contrast, extrinsically aged skin is exemplified by deep, coarse wrinkles, mottled hyperpigmentation and a marked loss of elasticity and recoil. The two major environmental influences which induce extrinsic ageing are: (i) chronic exposure to solar ultraviolet (UV) irradiation (termed photoageing) and (ii) smoking. This review discusses the changes associated with the ageing process in the skin, with particular emphasis on the role played by the elastic fibre network in maintaining dermal function. The review concludes with a discussion of a short‐term assay for independent assessment of the efficacy of anti‐ageing cosmetic products using the elastic fibre component fibrillin‐1 as a biomarker of extracellular matrix repair.
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“According to Farage et al. [12], skin ageing occurs inevitably as a consequence of physiological changes over time due to genetic factors and changes in cell metabolism and the tissue structure [13 -16].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [14]
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In the citing paper
“Components such as fibrillins, fibulins, microfibril-associated glycoproteins (MAGPs) -mainly MAGP1 and MAGP2, and proteoglycans form a scaffold in which tropoelastin molecules are deposited on preformed bundles of fibrillin microfibrils in the pericellular space [14, 46, 48].”
From Elastin structure and its involvement in skin photoageing (2017) · cites this paper as [14]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Acute exposure of skin to UV radiation can cause sunburn, resulting in a large inflammatory response causing characteristic redness, swelling and heat. In addition, altered pigmentation, immune suppression and damage to the dermal extracellular matrix can occur [24,25,56,142,143].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
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“Delivery of nutrients is dependent on diffusion from the vascularized dermis [24]”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
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“The epidermis is a challenged environment for nutrient delivery, as it lacks the blood vessels that normally deliver nutrients to cells.”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
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“By comparison, chronic long-term exposure to UV radiation causes premature aging of the skin, with dramatic and significant disruption to skin structure, and leads to the development of skin cancer [6,24].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
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“Elastic fibres throughout the dermis are also susceptible to UV radiation, with accumulation of disorganised elastic fibre proteins evident in severely photoaged skin. Indeed, this accumulation, termed ‘solar elastosis’, is considered to be a defining characteristic of severely photoaged skin [6,22,24,126].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
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In the citing paper
“Both the epidermal and dermal layers of skin are susceptible to chronic UV exposure; however, the most profound changes occur in the extracellular matrix of the dermis [24].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
The cited source says what the claim attributes to it.
In the citing paper
“Acute exposure of skin to UV radiation can cause sunburn, resulting in a large inflammatory response causing characteristic redness, swelling and heat. In addition, altered pigmentation, immune suppression and damage to the dermal extracellular matrix can occur [24,25,56,142,143].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
The cited source says what the claim attributes to it.
In the citing paper
“Elastic fibres throughout the dermis are also susceptible to UV radiation, with accumulation of disorganised elastic fibre proteins evident in severely photoaged skin. Indeed, this accumulation, termed ‘solar elastosis’, is considered to be a defining characteristic of severely photoaged skin [6,22,24,126].”
From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [24]
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Citations
Cites
Matrix Metalloproteinases: A Review
Birkedal‐Hansen, H., Moore, W. G. I., Bodden, M., Windsor, L. J., BIRKEDAL‐HANSEN, B., DeCarlo, A. A., & Engler, J. A. (1993) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411930040020401 · Cited by 2,980
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501
Van Wart, H. E., & Birkedal-Hansen, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5578 · Cited by 1,475
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410
Kielty, C. M., Sherratt, M. J., & Shuttleworth, C. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.14.2817 · Cited by 870
Self-citationMatrix-Degrading Metalloproteinases in Photoaging
Quan, T., Qin, Z., Xia, W., Shao, Y., Voorhees, J. J., & Fisher, G. J. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.8 · Cited by 740
Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J., Wang, Z., Datta, S. C., Fisher, G. J., & Voorhees, J. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00902.x · Cited by 643
Topical tretinoin for photoaged skin
Kligman, A. M., Grove, G. L., Hirose, R., & Leyden, J. J. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70242-9 · Cited by 620
Vrhovski, B., & Weiss, A. S. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2580001.x · Cited by 544
Structural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535
Research works printed but not linked: 1
- 10.1001/archderm.1995.01690210067011 · DOI
Cited by
Sorted by citations
The Roles of Vitamin C in Skin Health.
Pullar, J., Carr, A., & Vissers, M. (2017) · Nutrients · doi:10.3390/nu9080866 · Cited by 756
“In addition, altered pigmentation, immune suppression and damage to the dermal extracellular matrix can occur [24,25,56,142,143].”
BackgroundInfluentialMolecular aspects of skin ageing
Naylor, E. C., Watson, R. E. B., & Sherratt, M. J. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.04.011 · Cited by 567
Self-citationThe dynamic anatomy and patterning of skin
Wong, R., Geyer, S. H., Weninger, W. J., Guimberteau, J.-C., & Wong, J. K. F. (2015) · Experimental Dermatology · doi:10.1111/exd.12832 · Cited by 546
The Facial Aging Process From the “Inside Out”
Swift, A., Liew, S., Weinkle, S. H., Garcia, J. K., & Silberberg, M. (2020) · Aesthetic Surgery Journal · doi:10.1093/asj/sjaa339 · Cited by 468
Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation
Amaro-Ortiz, A., Yan, B., & D'Orazio, J. (2014) · Molecules · doi:10.3390/molecules19056202 · Cited by 360
Metadata
- Authors
- Langton, A. K., Sherratt, M. J., Griffiths, C. E. M., & Watson, R. E. B.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Corresponding author
- Watson, R. E. B.
- Venue
- International Journal of Cosmetic Science
- Publisher
- Wiley
- Published
- 2010-06-21
- Volume
- 32
- Issue
- 5
- Pages
- 330-339
- ISSN
- 0142-5463 (ISSN-L)
- 1468-2494
- OpenAlex
- W2129424926
- Cited by
- 177
- References
- 84
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 9 · 2023: 9 · 2022: 13 · 2021: 22 · 2020: 19 · 2019: 14 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 9 · 2014: 5 · 2013: 10 · 2012: 5
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- International Journal of Cosmetic Science (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- National Institute for Health and Care Research
- Manchester Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- skin aging, elastic fibers, intrinsic aging, extrinsic aging, photoaging, UV irradiation, smoking, fibrillin-1, extracellular matrix, anti-aging cosmetics, biomarkers, wrinkles
- MeSH terms
- Aging, Elastin, Extracellular Matrix, Humans, Protein Conformation, Skin Aging
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