Comorbid migraine is associated with a negative impact on quality of life in patients with major depression
Open accessAbstract
This study investigated the impact of migraine on health-related quality of life (HRQoL) among patients with major depressive disorder (MDD). We prospectively enrolled 151 consecutive psychiatric out-patients meeting DSM-IV criteria for MDD. Migraine and other headache types were diagnosed based on the International Classification of Headache Disorders, 2nd edition (2004). The Short Form-36 (SF-36) was administered as a generic instrument of HRQoL. Among 151 patients with MDD, migraine (N = 73, 48.3%) was very common. Comorbidity of migraine predicted a significantly negative impact on all physical subscales and vitality but not on the other mental subscales of the SF-36 after controlling for depression, age and gender. The presence of migraine should be considered as an important physical symptom in clinic-based MDD samples. Simultaneous management of depression and severe headaches, especially migraine, might improve HRQoL in patients with MDD.
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In the general population, depression is associated with a wide range of health, mental health, and neurological conditions, such as chronic pain, headaches and migraines, diabetes, low testosterone, cardiovascular/cerebrovascular/small vessel ischemic disease, PD, MCI, and AD.
“In the general population, depression is associated with a wide range of health, mental health, and neurological conditions, such as 1) chronic pain [71–75]; 2) headaches and migraines [76–79]; 3) diabetes [80–82]; 4) low testosterone [83–85]; 5) cardiovascular, cerebrovascular, and small vessel ischemic disease [86–92]; 6) PD [93]; 7) MCI [94–96]; and 8) AD [97].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [76]
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- Authors
- Hung, C.-I., Liu, C.-Y., Fuh, J.-L., Juang, Y.-Y., & Wang, S.-J.
- Affiliations
- Chang Gung University (TW)
- Taipei Veterans General Hospital (TW)
- Corresponding author
- Wang, S-J
- ORCID
- Fuh, J-L
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2006-01
- Volume
- 26
- Issue
- 1
- Pages
- 26-32
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W1968965408
- Cited by
- 36
- References
- 34
- Citations by year
- 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 6
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cephalalgia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Chang Gung Medical Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Keywords
- migraine, major depressive disorder, comorbidities, health-related quality of life, headache, physical function, vitality, SF-36, psychiatric outpatients
- MeSH terms
- Adolescent, Adult, Aged, Chronic Disease, Major Depressive Disorder, Depressive Disorder, Major, Female, Health Status, Humans, Male, Middle Aged, Migraine Disorders, Outpatients, Prospective Studies, Quality of Life, Severity of Illness Index, Comorbidity
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