Alterations of the endocannabinoid system in an animal model of migraine: Evaluation in cerebral areas of rat
Abstract
Endocannabinoids are involved in the modulation of pain and hyperalgesia. In this study we investigated the role of the endocannabinoid system in the migraine model based on nitroglycerin-induced hyperalgesia in the rat. Male rats were injected with nitroglycerin (10 mg/kg, i.p.) or vehicle and sacrificed 4 h later. The medulla, the mesencephalon and the hypothalamus were dissected out and utilized for the evaluation of activity of fatty acid amide hydrolase (that degrades the endocannabinoid anandamide), monoacylglycerol lipase (that degrades the endocannabinoid 2-arachidonoylglycerol), and binding sites specific for cannabinoid (CB) receptors. The findings obtained show that nitroglycerin-induced hyperalgesia is associated with increased activity of both hydrolases and increased density of CB binding sites in the mesencephalon. In the hypothalamus we observed an increase in the activity of fatty acid amide hydrolase associated with an increase in density of CB binding sites, while in the medulla only the activity of fatty acid amide hydrolase was increased. Anandamide also proved effective in preventing nitroglycerin-induced activation (c-Fos) of neurons in the nucleus trigeminalis caudalis. These data strongly support the involvement of the endocannabinoid system in the modulation of nitroglycerin-induced hyperalgesia, and, possibly, in the pathophysiological mechanisms of migraine.
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Nitroglycerin-induced hyperalgesia in rats is associated with increased activity of both FAAH and MAGL, and increased density of cannabinoid receptors binding sites in the mesencephalon.
“Another study shows that nitroglycerin-induced hyperalgesia in rats is associated with increased activity of both FAAH and MAGL, and increased density of cannabinoid receptors binding sites in the mesencephalon.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Greco et al, 2010
A dysfunction of the endocannabinoid system may contribute to the development of migraine attacks, and modulation of this system can be useful for the treatment of pain associated with migraine.
“These studies suggest that a dysfunction of the endocannabinoid system may contribute to the development of migraine attacks and modulation of this system can be useful for the treatment of pain associated to migraine.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Greco et al, 2010
Cannabinoids act on brain reward pathways; CB1 receptors are co-localized with opioid receptors on dopaminergic cells of the nucleus accumbens.
“Cannabinoids, like many analgesics and recreational drugs, act on the brain’s reward pathways. Cannabinoid-1 receptors (CB1R) are co-localized with the opioid receptors on the dopaminergic cells of the nucleus accumbens, probably the most important structure in human reward pathways, which partly overlaps the antinociceptive pathways [30–32].”
From Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial (2012) · cites this paper as [32]
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- Authors
- Greco, R., Gasperi, V, Sandrini, G., Bagetta, G., Nappi, G., Maccarrone, M., & Tassorelli, C.
- Affiliations
- University of Pavia (IT)
- University of Rome Tor Vergata (IT)
- University of Calabria (IT)
- University of Teramo (IT)
- Corresponding author
- Tassorelli, C
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2009-07-01
- Volume
- 30
- Issue
- 3
- Pages
- 296-302
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W2084872420
- Cited by
- 64
- References
- 50
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 1 · 2017: 10 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cephalalgia (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- endocannabinoid system, migraine, fatty acid amide hydrolase, monoacylglycerol lipase, cannabinoid receptors, anandamide, 2-arachidonoylglycerol, medulla, midbrain, hypothalamus, c-fos, nucleus tractus solitarius, trigeminal neurons, pain modulation
- MeSH terms
- Fatty Acid Amide Hydrolases, Amidohydrolases, Animals, Brain, Disease Models, Animal, Nitroglycerin, Hyperalgesia, Hypothalamus, Male, Medulla Oblongata, Mesencephalon, Migraine Disorders, Monoacylglycerol Lipases, Trigeminal Caudal Nucleus, Vasodilator Agents, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Receptors, Cannabinoid, Rats, Cannabinoid Receptor Modulators, Endocannabinoids
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