Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376 · see citing works

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092 · see citing works

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011 · see citing works

Determination and characterization of a cannabinoid receptor in rat brain

Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · see citing works

Chronic catheterization of the spinal subarachnoid space

Yaksh, T. L., & Rudy, T. A. (1976) · Physiology & Behavior · doi:10.1016/0031-9384(76)90029-9 · Cited by 2,242 · see citing works

Neuropathic pain: aetiology, symptoms, mechanisms, and management

Woolf, C. J., & Mannion, R. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01307-0 · Cited by 2,231 · see citing works

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

Herkenham, M., Lynn, A., Johnson, M., Melvin, L., de Costa, B., & Rice, K. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00563.1991 · Cited by 2,159 · see citing works

Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586 · see citing works

Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action

Sindrup, S. H., & Jensen, T. S. (1999) · Pain · doi:10.1016/s0304-3959(99)00154-2 · Cited by 1,142 · see citing works

Effects of Desipramine, Amitriptyline, and Fluoxetine on Pain in Diabetic Neuropathy

Max, M. B., Lynch, S. A., Muir, J., Shoaf, S. E., Smoller, B. M., & Dubner, R. A. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205073261904 · Cited by 1,113 · see citing works

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

Arnér, S., & Meyerson, B. A. (1988) · Pain · doi:10.1016/0304-3959(88)90198-4 · Cited by 992 · see citing works

Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions

Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00073-2 · Cited by 817 · see citing works

Cannabinoid receptors and pain

Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works

A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes

Kingery, W. S. (1997) · Pain · doi:10.1016/s0304-3959(97)00049-3 · Cited by 678 · see citing works

Opioids versus antidepressants in postherpetic neuralgia

Raja, S. N., Haythornthwaite, J. A., Pappagallo, M., Clark, M. R., Travison, T. G., Sabeen, S., Royall, R. M., & Max, M. B. (2002) · Neurology · doi:10.1212/wnl.59.7.1015 · Cited by 593 · see citing works

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

Portenoy, R. K., Foley, K. M., & Inturrisi, C. E. (1990) · Pain · doi:10.1016/0304-3959(90)90025-9 · Cited by 565 · see citing works

Amitriptyline versus placebo in postherpetic neuralgia

Watson, C. P. N., Evans, R. J., Reed, K. L., Merskey, H., Goldsmith, L. S., & Warsh, J. J. (1982) · Neurology · doi:10.1212/wnl.32.6.671 · Cited by 560 · see citing works

Oral Opioid Therapy for Chronic Peripheral and Central Neuropathic Pain

Rowbotham, M. C., Twilling, L., Davies, P. S., Reisner, L. A., Taylor, K., & Mohr, D. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021420 · Cited by 529 · see citing works

ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity

Ji, R., Befort, K., Brenner, G. J., & Woolf, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00478.2002 · Cited by 461 · see citing works

Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve

Tal, M., & Bennett, G. J. (1994) · Pain · doi:10.1016/0304-3959(94)90013-2 · Cited by 436 · see citing works

Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

Mannion, R., Costigan, M., Décosterd, I., Amaya, F., Ma, Q., Holstege, J. C., Ji, R., Acheson, A. L., Lindsay, R. M., Wilkinson, G. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9385 · Cited by 435 · see citing works

The endocannabinoid system as a target for therapeutic drugs

Piomelli, D., Giuffrida, A., Calignano, A., & Rodrı́guez de Fonseca, F. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01482-6 · Cited by 421 · see citing works

Chronic Morphine Induces Downregulation of Spinal Glutamate Transporters: Implications in Morphine Tolerance and Abnormal Pain Sensitivity

Mao, J., Sung, B., Ji, R., & Lim, G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08312.2002 · Cited by 409 · see citing works

CB2 cannabinoid receptor-mediated peripheral antinociception

Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391 · see citing works

The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain

Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works

Systemic lidocaine for neuropathic pain relief

Mao, J., & Chen, L. L. (2000) · Pain · doi:10.1016/s0304-3959(00)00229-3 · Cited by 378 · see citing works

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

Kruman, I. I., Guo, Q., & Mattson, M. P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980201)51:3 · Cited by 377 · see citing works

Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain

Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00022-k · Cited by 329 · see citing works

Desipramine relieves postherpetic neuralgia

Kishore-Kumar, R., Max, M. B., Schafer, S. C., Gaughan, A. M., Smoller, B. M., Gracely, R. H., & Dubner, R. A. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.33 · Cited by 325 · see citing works

The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain

Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13308-5 · Cited by 307 · see citing works

Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial

Max, M. B., Kishore-Kumar, R., Schafer, S. C., Meister, B., Gracely, R. H., Smoller, B. M., & Dubner, R. A. (1991) · Pain · doi:10.1016/0304-3959(91)90157-s · Cited by 301 · see citing works

The ups and downs of MEK kinase interactions

Hagemann, C., & Blank, J. L. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00220-0 · Cited by 278 · see citing works

Extracellular‐Regulated Kinases and Phosphatidylinositol 3‐Kinase Are Involved in Brain‐Derived Neurotrophic Factor‐Mediated Survival and neuritogenesis of the Neuroblastoma Cell Line SH‐SY5Y

Encinas, M., Iglesias, M., Llecha, N., & Comella, J. X. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731409.x · Cited by 278 · see citing works

Antihyperalgesic effects of spinal cannabinoids

Richardson, J. D., Aanonsen, L., & Hargreaves, K. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01621-x · Cited by 275 · see citing works

Desipramine relieves postherpetic neuralgia

Krol, L. V. (1990) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(05)82313-3 · Cited by 269 · see citing works

Cannabinoid CB1 Receptor Expression in Rat Spinal Cord

Farquhar-Smith, W. P., Egertová, M., Bradbury, E. J., McMahon, S. B., Rice, A. S. C., & Elphick, M. R. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0844 · Cited by 268 · see citing works

Marijuana and Medicine: Assessing the Science Base: A Summary of the 1999 Institute of Medicine Report

Watson, S. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.6.547 · Cited by 226 · see citing works

The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

Bridges, D., Ahmad, K., & Rice, A. S. C. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704110 · Cited by 221 · see citing works

Pharmacological actions and therapeutic uses of cannabis and cannabinoids

Kumar, R., Chambers, W. A., & Pertwee, R. G. (2001) · Anaesthesia · doi:10.1046/j.1365-2044.2001.02269.x · Cited by 218 · see citing works

Spinal and supraspinal components of cannabinoid-induced antinociception.

Lichtman, A. H., & Martin, B. R. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20242-7 · Cited by 218 · see citing works

Antinociceptive activity of intrathecally administered cannabinoids alone, and in combination with morphine, in mice.

Welch, S. P., & Stevens, D. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10720-9 · Cited by 208 · see citing works

Morphine differentially affects the sensory and affective pain ratings in neurogenic and idiopathic forms of pain

Kupers, R. C., Konings, H., Adriaensen, H. A., & Gybels, J. (1991) · Pain · doi:10.1016/0304-3959(91)90004-h · Cited by 206 · see citing works

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

Jadad, A. R., Carroll, D., Glynn, C. J., McQuay, H. J., & Moore, R. A. (1992) · The Lancet · doi:10.1016/0140-6736(92)91194-d · Cited by 200 · see citing works

Down-regulation of μ-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy

Zhang, X., Bao, L., Shi, T.-J., Ju, G., Elde, R., & Hökfelt, T. G. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00240-6 · Cited by 189 · see citing works

Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia

Richardson, J. D., Aanonsen, L., & Hargreaves, K. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00451.1998 · Cited by 182 · see citing works

Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3

Siuciak, J. A., Altar, A. C., Wiegand, S. J., & Lindsay, R. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91556-3 · Cited by 169 · see citing works

Gabapentin in Pain Management

Mao, J., & Chen, L. L. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200009000-00034 · Cited by 161 · see citing works

Cannabis and endogenous cannabinoid systems

Childers, S. R., & Breivogel, C. S. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00075-1 · Cited by 155 · see citing works

Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain

Oyesiku, N. M., Evans, C.-O., Houston, S., Darrell, R. S., Smith, J. S., Fulop, Z. L., Dixon, C. E., & Stein, D. G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01501-2 · Cited by 153 · see citing works

SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice

Richardson, J. D., Aanonsen, L., & Hargreaves, K. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00952-1 · Cited by 150 · see citing works

The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive

Ossipov, M. H., Lopez, Y., Nichols, M. L., Bian, D., & Porreca, F. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12022-v · Cited by 149 · see citing works

Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles

Jansen, E. M., Haycock, D. A., Ward, S. J., & Seybold, V. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)90428-c · Cited by 140 · see citing works

Gabapentin in Pain Management

Mao, J., & Chen, L. L. (2000) · Anesthesia & Analgesia · doi:10.1213/00000539-200009000-00034 · Cited by 137 · see citing works

The neurobiology of cannabinoid analgesia

Walker, J. M., Hohmann, A. G., Martin, W. J., Strangman, N. M., Huang, S. M., & Tsou, K. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00289-1 · Cited by 134 · see citing works

Expression of brain-derived neurotrophic factor in rat dorsal root ganglia, spinal cord and gracile nuclei in experimental models of neuropathic pain

Ha, S.-O., Kim, J. K., Hong, H.-S., Kim, D. S., & Cho, H. J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00353-0 · Cited by 132 · see citing works

A comparative trial of amitriptyline and zimelidine in post-herpetic neuralgia

Watson, C. B., & Evans, R. J. (1985) · Pain · doi:10.1016/0304-3959(85)90009-0 · Cited by 130 · see citing works

Hyperalgesia due to nerve damage: role of nerve growth factor

Theodosiou, M., Rush, A. R., Zhou, F. X., Hu, D., Walker, S. J., & Tracey, J. D. (1999) · Pain · doi:10.1016/s0304-3959(99)00018-4 · Cited by 130 · see citing works

Pain relief with oral cannabinoids in familial Mediterranean fever

Holdcroft, A., Smith, M., Jacklin, A., Hodgson, H. J. F., Smith, B., Newton, M., & Evans, F. J. (1997) · Anaesthesia · doi:10.1111/j.1365-2044.1997.139-az0132.x · Cited by 129 · see citing works

Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats

Wegert, S., Ossipov, M. H., Nichols, M. L., Bian, D., Vanderah, T. W., Malan, P. T., & Porreca, F. (1997) · Pain · doi:10.1016/s0304-3959(97)03337-x · Cited by 125 · see citing works

Pre- and postsynaptic localizations of the CB1 cannabinoid receptor in the dorsal horn of the rat spinal cord

Salio, C., Fischer, J., Franzoni, M. F., & Conrath, M. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00584-x · Cited by 120 · see citing works

Cannabinoid Transmission and Pain Perception

Martin, B. R., & Lichtman, A. H. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0218 · Cited by 117 · see citing works

Cannabis for migraine treatment: the once and future prescription? An historical and scientific review

Russo, E. B. (1998) · Pain · doi:10.1016/s0304-3959(98)00033-5 · Cited by 117 · see citing works

Treatment of post-herpetic neuralgia: Antidepressants

Max, M. B. (1994) · Annals of Neurology · doi:10.1002/ana.410350715 · Cited by 112 · see citing works

Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity

Strangman, N. M., Patrick, S. L., Hohmann, A. G., Tsou, K., & Walker, J. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01031-2 · Cited by 109 · see citing works

Cannabinoids and Pain

Lever, I. J., & Rice, A. S. C. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_10 · Cited by 108 · see citing works

Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain

Siegling, A., Hofmann, H. A., Denzer, D., Mauler, F., & De Vry, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00798-1 · Cited by 108 · see citing works

Two distinctive antinociceptive systems in rats with pathological pain

Mao, J., Price, D. D., Lü, J., Keniston, L., & Mayer, D. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00998-2 · Cited by 104 · see citing works

Spinal mechanisms ofΔ9-tetrahydrocannabinol-induced analgesia

Smith, P. B., & Martin, B. R. (1992) · Brain Research · doi:10.1016/0006-8993(92)90222-u · Cited by 91 · see citing works

Effects of Endogenous Neurotrophins on Sympathetic Sprouting in the Dorsal Root Ganglia and Allodynia Following Spinal Nerve Injury

Deng, Y.-S., Zhong, J.-H., & Zhou, X. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7432 · Cited by 89 · see citing works

The inhibition of nitric oxide-activated poly(ADP-ribose) synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat

Mao, J., Price, D. D., Zhu, J., Lü, J., & Mayer, D. J. (1997) · Pain · doi:10.1016/s0304-3959(97)00063-8 · Cited by 88 · see citing works

Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-d-aspartate receptors and protein kinase c and production of nitric oxide

Meller, S. T., Dykstra, C. L., & Gebhart, G. F. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00442-4 · Cited by 87 · see citing works

Cannabinoids as potential new analgesics

Fuentes, J., Ruiz‐Gayo, M., Manzanares, J., Vela, G., Reche, I., & Corchero, J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00290-8 · Cited by 72 · see citing works

Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (Dronabinol)

Gonzalez-Rosales, F., & Walsh, D. (1997) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(97)00229-7 · Cited by 62 · see citing works

Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats

Werner, N. A., & Koch, J. E. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04274-9 · Cited by 61 · see citing works

Upregulation of brain-derived neurotrophic factor and neuropeptide Y in the dorsal ascending sensory pathway following sciatic nerve injury in rat

Li, W., Xian, C. J., Rush, R. A., & Zhou, X. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00958-6 · Cited by 52 · see citing works

A call for more science, not more rhetoric, regarding opioids and neuropathic pain

Dubner, R. A. (1991) · Pain · doi:10.1016/0304-3959(91)90002-f · Cited by 48 · see citing works

Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells

Coffey, E. T., Åkerman, K. E. O., & Courtney, M. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00335-2 · Cited by 48 · see citing works

Changes in opioid and cannabinoid receptor protein following short-term combination treatment with delta(9)-tetrahydrocannabinol and morphine.

Cichewicz, D. L., Haller, V. L., & Welch, S. P. (2001) · PubMed · Cited by 47 · see citing works

The Effects of Lidocaine on the Activity of Glutamate Transporter EAAT3: The Role of Protein Kinase C and Phosphatidylinositol 3-Kinase

Do, S.-H., Fang, H., Ham, B.-M., & Zuo, Z. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200211000-00030 · Cited by 47 · see citing works

Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors

Hamann, W., & di Vadi, P. P. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05429-4 · Cited by 45 · see citing works

Suppression of neuropathic pain behavior in rats by a non-psychotropic synthetic cannabinoid with NMDA receptor-blocking properties

Zeltser, R., Seltzer, Z., Eisen, A., Feigenbaum, J. J., & Mechoulam, R. (1991) · Pain · doi:10.1016/0304-3959(91)90016-q · Cited by 43 · see citing works

The Neurobiology of Pain and Its Modulation

Dubner, R. A., & Hargreaves, K. (1989) · Clinical Journal of Pain · doi:10.1097/00002508-198906002-00002 · Cited by 43 · see citing works

Deafferentation Pain Syndromes

Davar, G., & Maciewicz, R. J. (1989) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30814-4 · Cited by 43 · see citing works

BDNF induces glutamate release in cerebrocortical nerve terminals and in cortical astrocytes

Pascual, M., Climent, E., & Guerri, C. (2001) · Neuroreport · doi:10.1097/00001756-200108280-00017 · Cited by 42 · see citing works

Release of immunoreactive brain-derived neurotrophic factor in the spinal cord of the rat following sciatic nerve transection.

Walker, S. M., Mitchell, V. A., White, D. M., Rush, R. A., & Duggan, A. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02259-4 · Cited by 34 · see citing works

Nerve Growth Factor Enhances Neurotransmitter Release from PC12 Cells by Increasing Ca2+-Responsible Secretory Vesicles through the Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase

Amino, S., Itakura, M., Ohnishi, H., Tsujimura, J., Koizumi, S., Takei, N., & Takahashi, M. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003179 · Cited by 34 · see citing works

HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test

Gühring, H., Schuster, J., Hamza, M., Ateş, M., Kotalla, C., & Brune, K. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01313-9 · Cited by 31 · see citing works

A PKCβ isoform mediates phorbol ester‐induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells

Trollér, U., Zeidman, R., Svensson, K., & Larsson, C. U. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03043-5 · Cited by 30 · see citing works

Analysis of the Medical Use of Marijuana and its Societal Implications

Taylor, H. G. (1998) · Journal of the American Pharmaceutical Association (1996) · doi:10.1016/s1086-5802(16)30318-7 · Cited by 24 · see citing works

Dynorphin-independent spinal cannabinoid antinociception

Gardell, L. R., Ossipov, M. H., Vanderah, T. W., Lai, J., & Porreca, F. (2002) · Pain · doi:10.1016/s0304-3959(02)00173-2 · Cited by 17 · see citing works

Untitled work

(2000) · doi:10.1002/1098-2396(20001215)38:4

The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707442 · Cited by 1,953 · see citing works

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

Zhuang, Z., Gerner, P., Woolf, C. J., & Ji, R. (2005) · Pain · doi:10.1016/j.pain.2004.12.022 · Cited by 774 · see citing works

The Endocannabinoid System and Pain

Guindon, J., & Hohmann, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789824660 · Cited by 476 · see citing works

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works

Cannabinoids and Pain: New Insights From Old Molecules

Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01259 · Cited by 417 · see citing works

Cell Signaling and the Genesis of Neuropathic Pain

Ji, R., & Strichartz, G. R. (2004) · Science s STKE · doi:10.1126/stke.2522004re14 · Cited by 371 · see citing works

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

Pertwee, R. G. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00108.x · Cited by 314 · see citing works

Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside

Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works

The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain

Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes

Manzanares, J., Julian, M., & Carrascosa, A. (2006) · Current Neuropharmacology · doi:10.2174/157015906778019527 · Cited by 287 · see citing works

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

Costa, B., Comelli, F., Bettoni, I., Colleoni, M., & Giagnoni, G. (2008) · Pain · doi:10.1016/j.pain.2008.06.003 · Cited by 286 · see citing works

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

Jayamanne, A., Greenwood, R., Mitchell, V. A., Aslan, S., Piomelli, D., & Vaughan, C. W. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706510 · Cited by 287 · see citing works

Cannabis and Pain: A Clinical Review

Hill, K. P., Palastro, M. D., Johnson, B., & Ditre, J. W. (2017) · Cannabis and Cannabinoid Research · doi:10.1089/can.2017.0017 · Cited by 282 · see citing works

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy

Wallace, M. S., Marcotte, T. D., Umlauf, A., Gouaux, B., & Atkinson, J. H. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2015.03.008 · Cited by 276 · see citing works

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats

Petrosino, S., Palazzo, E., de Novellis, V., Bisogno, T., Rossi, F., Maione, S., & Di Marzo, V. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.08.011 · Cited by 227 · see citing works

Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain

Mitrirattanakul, S., Ramakul, N., Guerrero, A. V., Matsuka, Y., Ono, T., Iwase, H., Mackie, K., Faull, K. F., & Spigelman, I. (2006) · Pain · doi:10.1016/j.pain.2006.06.016 · Cited by 207 · see citing works

The Role of the Endocannabinoid System in Pain

Woodhams, S. G., Sagar, D. R., Burston, J. J., & Chapman, V. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-46450-2_7 · Cited by 205 · see citing works

The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

Pertwee, R. G. (2005) · The AAPS Journal · doi:10.1208/aapsj070364 · Cited by 204 · see citing works

The endogenous cannabinoid system and its role in nociceptive behavior

Cravatt, B. F., & Lichtman, A. H. (2004) · Journal of Neurobiology · doi:10.1002/neu.20080 · Cited by 203 · see citing works

Modulation of pain transmission by G-protein-coupled receptors

Pan, H., Wu, Z.-Z., Zhou, H.-Y., Chen, S.-R., Zhang, H., & Li, D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.003 · Cited by 197 · see citing works

Cannabinoids and Pain: Sites and Mechanisms of Action

Starowicz, K., & Finn, D. P. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.05.003 · Cited by 192 · see citing works

The Highs and Lows of Cannabinoid Receptor Expression in Disease: Mechanisms and Their Therapeutic Implications

Miller, L. K., & Devi, L. A. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003491 · Cited by 179 · see citing works

Cannabinoid Mechanisms of Pain Suppression

Walker, J. M., & Hohmann, A. G. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_17 · Cited by 177 · see citing works

Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury

Romero-Sandoval, A., Nutile-McMenemy, N., & DeLeo, J. A. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318167af74 · Cited by 168 · see citing works

The ERK/MAPK pathway, as a target for the treatment of neuropathic pain

Ma, W., & Quirion, R. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.4.699 · Cited by 165 · see citing works

Cannabinoid–opioid interactions during neuropathic pain and analgesia

Bushlin, I., Rozenfeld, R., & Devi, L. A. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.09.009 · Cited by 163 · see citing works

Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain

Jhaveri, M. D., Richardson, D., Kendall, D. A., Barrett, D. A., & Chapman, V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-06.2006 · Cited by 159 · see citing works

The analgesic potential of cannabinoids.

Elikottil, M., Gupta, M., & Gupta, P. (2018) · Journal of Opioid Management · doi:10.5055/jom.2009.0034 · Cited by 141 · see citing works

Neuroimmune interactions and pain: focus on glial-modulating targets.

Romero-Sandoval, E. A., Horvath, R. J., & DeLeo, J. A. (2008) · PubMed · Cited by 140 · see citing works

Cannabinoid Receptors: An Update on Cell Signaling, Pathophysiological Roles and Therapeutic Opportunities in Neurological, Cardiovascular, and Inflammatory Diseases

Haspula, D., & Clark, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207693 · Cited by 137 · see citing works

Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain

Walczak, J.-S., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.010 · Cited by 133 · see citing works

Lack of Analgesia by Oral Standardized Cannabis Extract on Acute Inflammatory Pain and Hyperalgesia in Volunteers

Kraft, B., Frickey, N., Kaufmann, R. M., Reif, M., Frey, R., Gustorff, B., & Kress, H. G. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31817881e1 · Cited by 129 · see citing works

The endocannabinoid system is modulated in response to spinal cord injury in rats

García‐Ovejero, D., Arévalo‐Martín, Á., Petrosino, S., Docagne, F., Hagen, C., Bisogno, T., Watanabe, M., Guaza, C., Marzo, V. D., & Molina‐Holgado, E. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.015 · Cited by 125 · see citing works

Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist

Amaya, F., Shimosato, G., Kawasaki, Y., Hashimoto, S., Tanaka, Y., Ji, R., & Tanaka, M. (2006) · Pain · doi:10.1016/j.pain.2006.04.001 · Cited by 121 · see citing works

Expression of Central Glucocorticoid Receptors after Peripheral Nerve Injury Contributes to Neuropathic Pain Behaviors in Rats

Wang, S., Lim, G., Zeng, Q., Sung, B., Ai, Y., Guo, G., Yang, L., & Mao, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3058-04.2004 · Cited by 118 · see citing works

A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats

Pascual, D., Goicoechea, C., Suardíaz, M., & Martín, M. I. (2005) · Pain · doi:10.1016/j.pain.2005.07.008 · Cited by 117 · see citing works

Cannabinoids and Multiple Sclerosis

Pertwee, R. G. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0005-2 · Cited by 110 · see citing works

Cannabinoids and Pain

Lever, I. J., & Rice, A. S. C. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_10 · Cited by 108 · see citing works

Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve

Costa, B., Trovato, A. E., Colleoni, M., Giagnoni, G., Zarini, E., & Croci, T. (2005) · Pain · doi:10.1016/j.pain.2005.03.043 · Cited by 104 · see citing works

AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

Costa, B., Siniscalco, D., Trovato, A. E., Comelli, F., Sotgiu, M. L., Colleoni, M., Maione, S., Rossi, F., & Giagnoni, G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706798 · Cited by 99 · see citing works

Pathophysiology and treatment of pain in joint disease☆

Schaible, H., Schmelz, M., & Tegeder, I. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.01.011 · Cited by 98 · see citing works

Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury

Esposito, E., Paterniti, I., Mazzon, E., Genovese, T., Paola, R. D., Galuppo, M., & Cuzzocrea, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.006 · Cited by 97 · see citing works

Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55

Alba, R. G., Barragán‐Iglesias, P., González‐Hernández, A., Valdez-Moráles, E. E., Granados‐Soto, V., Condés‐Lara, M., Rodríguez, M. G., & Marichal‐Cancino, B. A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01496 · Cited by 94 · see citing works

Interaction of the cannabinoid and opioid systems in the modulation of nociception

Welch, S. P. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782794 · Cited by 92 · see citing works

Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain

Guindon, J., & Beaulieu, P. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.002 · Cited by 90 · see citing works

Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain

Bushlin, I., Gupta, A., Stockton, S. D., Miller, L. K., & Devi, L. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049789 · Cited by 90 · see citing works

Actions of N-arachidonyl-glycine in a rat neuropathic pain model

Vuong, L. A. Q., Mitchell, V. A., & Vaughan, C. W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.004 · Cited by 89 · see citing works

Incerta-thalamic Circuit Controls Nocifensive Behavior via Cannabinoid Type 1 Receptors

Wang, H., Dong, P., He, C., Feng, X.-Y., Huang, Y., Yang, W.-W., Gao, H.-J., Shen, X., Lin, S., Cao, S.-X., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.04.027 · Cited by 78 · see citing works

Dynamic changes to the endocannabinoid system in models of chronic pain

Sagar, D. R., Burston, J. J., Woodhams, S. G., & Chapman, V. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0390 · Cited by 76 · see citing works

Endocannabinoids: Effectors of glucocorticoid signaling

Balsevich, G., Petrie, G. N., & Hill, M. N. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.005 · Cited by 78 · see citing works

The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats

Ulugöl, A., Karadağ, Ç. H., İpçi, Y., Tamer, M., & Dökmeci, İ. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.08.061 · Cited by 73 · see citing works

Opioid and cannabinoid synergy in a mouse neuropathic pain model

Kazantzis, N. P., Casey, S. L., Seow, P. W., Mitchell, V. A., & Vaughan, C. W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13534 · Cited by 71 · see citing works

Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model

Barnes, N. S. A., Mitchell, V. A., Kazantzis, N. P., & Vaughan, C. W. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13337 · Cited by 70 · see citing works

Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats

Merriam, F. V., Wang, Z.-Y., GUÉRIOS, S. D., & Bjorling, D. E. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.076 · Cited by 70 · see citing works

Cannabis and pain: a scoping review

Pantoja‐Ruiz, C., Restrepo-Jiménez, P., Castañeda‐Cardona, C., Ferreirós, A., & Rosselli, D. (2021) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2021.06.018 · Cited by 76 · see citing works

The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain

Liang, Y.-C., Huang, C.-C., & Hsu, K.-S. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.04.019 · Cited by 68 · see citing works

Endocannabinoid system and pain: an introduction

Burston, J. J., & Woodhams, S. G. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003650 · Cited by 65 · see citing works

Alterations of the endocannabinoid system in an animal model of migraine: Evaluation in cerebral areas of rat

Greco, R., Gasperi, V, Sandrini, G., Bagetta, G., Nappi, G., Maccarrone, M., & Tassorelli, C. (2010) · Cephalalgia · doi:10.1111/j.1468-2982.2009.01924.x · Cited by 64 · see citing works

Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes

Walczak, J., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20821 · Cited by 62 · see citing works

CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain

Deng, L., Cornett, B., Mackie, K., & Hohmann, A. G. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.098483 · Cited by 60 · see citing works

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation

Mulpuri, Y., Marty, V. N., Munier, J. J., Mackie, K., Schmidt, B. L., Seltzman, H. H., & Spigelman, I. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.002 · Cited by 62 · see citing works

Involvement of the endocannabinoid system in osteoarthritis pain

Porta, C. L., Bura, S. A., Negrete, R., & Maldonado, R. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12468 · Cited by 61 · see citing works

Neuronal and glial localization of the cannabinoid‐1 receptor in the superficial spinal dorsal horn of the rodent spinal cord

Hegyi, Z., Kis, G. N., Holló, K., Ledent, C. A., & Antal, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06816.x · Cited by 61 · see citing works

Effect of the cannabinoid CB1receptor antagonist rimonabant on nociceptive responses and adjuvant‐induced arthritis in obese and lean rats

Croci, T., & Zarini, E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707138 · Cited by 61 · see citing works

Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis

Sainsbury, B., Bloxham, J., Pour, M. H., Padilla, M., & Enciso, R. (2021) · Journal of Dental Anesthesia and Pain Medicine · doi:10.17245/jdapm.2021.21.6.479 · Cited by 61 · see citing works

Therapeutic potential of cannabinoid receptor agonists as analgesic agents

Fox, A., & Bevan, S. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.6.695 · Cited by 60 · see citing works

Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury

Brownjohn, P. W., & Ashton, J. C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.028 · Cited by 57 · see citing works

Cannabinoid Agonists Inhibit Neuropathic Pain Induced by Brachial Plexus Avulsion in Mice by Affecting Glial Cells and MAP Kinases

Paszcuk, A. F., Dutra, R. C., Silva, K. A. B. S., Quintão, N. L. M., Campos, M. M., & Calixto, J. Β. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024034 · Cited by 58 · see citing works

High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity

Fitzgibbon, M., Finn, D. P., & Roche, M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv095 · Cited by 57 · see citing works

A rat model of unilateral hindpaw burn injury: Slowly developing rightwards shift of the morphine dose–response curve

Wang, S., Lim, G., Yang, L., Zeng, Q., Sung, B., Martyn, J. J. A., & Mao, J. (2005) · Pain · doi:10.1016/j.pain.2005.03.044 · Cited by 55 · see citing works

Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms

Spradley, J. M., Guindon, J., & Hohmann, A. G. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.03.007 · Cited by 54 · see citing works

Striatal CB 1 and D2 receptors regulate expression of each other, CRIP 1A and delta opioid systems

Blume, L. C., Bass, C. E., Childers, S. R., Dalton, G. D., Roberts, D. C. S., Richardson, J. M., Xiao, R., Selley, D. E., & Howlett, A. C. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12139 · Cited by 52 · see citing works

Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain

Hossain, M. Z., Ando, H., Unno, S., & Kitagawa, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041423 · Cited by 52 · see citing works

FAAH inhibition as a preventive treatment for migraine: A pre-clinical study

Greco, R., Demartini, C., Zanaboni, A. M., Tumelero, E., Reggiani, A. M., Misto, A., Piomelli, D., & Tassorelli, C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104624 · Cited by 49 · see citing works

Central glucocorticoid receptors regulate the upregulation of spinal cannabinoid-1 receptors after peripheral nerve injury in rats

Wang, S., Lim, G., Mao, J., Sung, B., Yang, L., & Mao, J. (2007) · Pain · doi:10.1016/j.pain.2006.12.019 · Cited by 46 · see citing works

Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics

Remesic, M., Hruby, V. J., Porreca, F., & Lee, Y. S. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00090 · Cited by 48 · see citing works

Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain

Pol, O., Murtra, P., Caracuel, L., Valverde, O., Puig, M. M., & Maldonado, R. J. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.002 · Cited by 47 · see citing works

Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus

Zhang, J., Wang, N., Chen, B., Wang, Y., He, J., Cai, X., Zhang, H., Wei, S., & Li, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.047 · Cited by 46 · see citing works

Modulation of opioids via protection of anandamide degradation by fatty acid amide hydrolase

Haller, V. L., Stevens, D. L., & Welch, S. P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.08.005 · Cited by 45 · see citing works

Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats

Kawasaki, Y., Kohno, T., & Ji, R.-R. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093583 · Cited by 44 · see citing works

Innovative and emerging applications of cannabis in food and beverage products: From an illicit drug to a potential ingredient for health promotion

Rasera, G. B., Ohara, A., & de Castro, R. J. S. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.06.035 · Cited by 44 · see citing works

Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice

Crowe, M. S., Leishman, E., Banks, M. L., Gujjar, R., Mahadevan, A., Bradshaw, H. B., & Kinsey, S. G. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13012 · Cited by 45 · see citing works

Is There Any Clinically Relevant Cannabinoid-Induced Analgesia?

Kraft, B. (2012) · Pharmacology · doi:10.1159/000337376 · Cited by 44 · see citing works

Actions of the endocannabinoid transport inhibitor AM404 in neuropathic and inflammatory pain models

Mitchell, V. A., Greenwood, R., Jayamanne, A., & Vaughan, C. W. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04692.x · Cited by 43 · see citing works

Descending Control Mechanisms

Ren, K., & Dubner, R. A. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00192-4 · Cited by 42 · see citing works

Development and expression of neuropathic pain in CB1 knockout mice

Castañé, A., Célèrier, E., Martín, M., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.07.022 · Cited by 42 · see citing works

Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development

Sharma, C., Sadek, B. S., Goyal, S. N., Sinha, S. K., Kamal, M. A., & Ojha, S. K. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/238482 · Cited by 40 · see citing works

Medical cannabis: A forward vision for the clinician

Fitzcharles, M., & Eisenberg, E. (2018) · European Journal of Pain · doi:10.1002/ejp.1185 · Cited by 39 · see citing works

The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury

Hestehave, S., Abelson, K., Pedersen, T. B., Finn, D. P., Andersson, D. R., & Munro, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-77640-8 · Cited by 39 · see citing works

Pain in neuropsychiatry: Insights from animal models

Bravo, L., Llorca-Torralba, M., Suárez‐Pereira, I., & Berrocoso, E. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.029 · Cited by 38 · see citing works

Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain

Liu, C., & Walker, J. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00498.2006 · Cited by 37 · see citing works

New targets for neuropathic pain therapeutics

Kinloch, R. A., & Cox, P. J. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.4.685 · Cited by 37 · see citing works

Reduction of Bone Cancer Pain by Activation of Spinal Cannabinoid Receptor 1 and Its Expression in the Superficial Dorsal Horn of the Spinal Cord in a Murine Model of Bone Cancer Pain

Furuse, S., Kawamata, T., Yamamoto, J., Niiyama, Y., Omote, K., Watanabe, M., & Namiki, A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181a51e0d · Cited by 37 · see citing works

Analysis of natural product regulation of opioid receptors in the treatment of human disease

Badal, S. A. M., Turfus, S. C., Rajnarayanan, R. V., Wilson-Clarke, C. F., & Sandiford, S. L. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.021 · Cited by 36 · see citing works

Cannabinoids in pain and inflammation

Mbvundula, E. C., Rainsford, K. D., & Bunning, R. A. D. (2004) · Inflammopharmacology · doi:10.1163/1568560041352275 · Cited by 36 · see citing works

Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis

Mlost, J., Kostrzewa, M., Małek, N., & Starowicz, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020342 · Cited by 36 · see citing works

SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain

Peng, G., Han, M., Du, Y., Lin, A., Yu, L., Zhang, Y., & Jing, N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.036756 · Cited by 35 · see citing works

IUPHAR review: Navigating the role of preclinical models in pain research

Karimi, S. A., Zahra, F. T., & Martin, L. J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107073 · Cited by 35 · see citing works

Contribution of Endocannabinoid Gene Expression and Genotype on Low Back Pain Susceptibility and Chronicity

Ramesh, D., D’Agata, A. L., Starkweather, A. R., & Young, E. E. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000508 · Cited by 34 · see citing works

Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon

da Silva, J. A., Biagioni, A. F., Almada, R. C., Crippa, J. A. S., Hallak, J. E. C., Zuardi, A. W., & Coimbra, N. C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.051 · Cited by 34 · see citing works

Central glucocorticoid receptors regulate the upregulation of spinal cannabinoid-1 receptors after peripheral nerve injury in rats

Wang, S., Lim, G., Mao, J., Sung, B., Yang, L., & Mao, J. (2007) · Pain · doi:10.1016/j.pain.2006.12.019 · Cited by 46 · see citing works

Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain

Liu, C., & Walker, J. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00498.2006 · Cited by 37 · see citing works

Cannabinoid Subtype-2 Receptors Modulate the Antihyperalgesic Effect of WIN 55,212–2 in Rats with Neuropathic SCI Pain

Resnick, D. K., Ahmed, M. M., Rajpal, S., Patel, A. U., Sweeney, C., Miranpuri, G. S., Tilghman, J. I., & Gerovac, T. A. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.07.096 · Cited by 1 · see citing works

Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain

Ahmed, M. M., Rajpal, S., Sweeney, C., Gerovac, T. A., Allcock, B., McChesney, S. L., Patel, A. U., Tilghman, J. I., Miranpuri, G. S., & Resnick, D. K. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.08.015 · Cited by 26 · see citing works

Activation of spinal and supraspinal cannabinoid-1 receptors leads to antinociception in a rat model of neuropathic spinal cord injury pain

Hama, A. T., & Sagen, J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.031 · Cited by 56 · see citing works