Oral Bacterial and Fungal Microbiome Impacts Colorectal Carcinogenesis
Open accessAbstract
Host's physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels. A few obligate anaerobic strains inhabiting the oral cavity are involved in the pathogenesis of oral diseases. Interestingly, these microbiota components are also enriched in gut inflammatory and tumor tissue. An altered microbiota composition - dysbiosis - and formation of polymicrobial biofilms seem to play important roles in the development of oral diseases and colorectal cancer. In this review, we describe the differences in composition of commensal microbiota in the oral cavity and large intestine and the mechanisms by which microbiota affect the inflammatory and carcinogenic response of the host.
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Various disease states are associated with the oral microbiome, including caries, periodontal disease, oral, esophageal, pancreatic, and colorectal cancers, cardiovascular disease, and inflammatory bowel disease.
“This is demonstrated by the association of various disease states with the oral microbiome, including not only caries and periodontal disease but also oral, esophageal, pancreatic, and colorectal cancers, cardiovascular disease, and inflammatory bowel disease.147, 148, 149, 150, 151, 152, 153”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [150]
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- Authors
- Klimesova, K., Jiraskova Zakostelska, Z., & Tlaskalova-Hogenova, H.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2018-04-20
- Volume
- 9
- Pages
- 774-774
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC5920026
- OpenAlex
- W2801786263
- Cited by
- 67
- References
- 147
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 18 · 2019: 10 · 2018: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Grantová Agentura České Republiky (17-06632Y, 16-06326S)
- Ministerstvo Zdravotnictví Ceské Republiky (15-27580A, 15-29336A, 15-30782A)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- oral microbiota, gut microbiota, colorectal cancer, colorectal carcinogenesis, dysbiosis, polymicrobial biofilms, oral diseases, inflammation, commensal microbiota, anaerobic bacteria, fungi, mucosal barrier, host-microbe interactions
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