The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Glutamate‐mediated neuronal–glial transmission
Open accessAbstract
The brain is the most complex organ of the human body. It is composed of several highly specialized and heterogeneous populations of cells, represented by neurones (e.g. motoneurons, projection neurons or interneurons), and glia represented by astrocytes, oligodendrocytes and microglia. In recent years there have been numerous studies demonstrating close bidirectional communication of neurons and glia at structural and functional levels. In particular, the excitatory transmitter glutamate has been shown to evoke a variety of responses in astrocytes and oligodendrocytes in the healthy as well as the diseased brain. Here we overview the multitude of glutamate sensing molecules expressed in glia and describe some general experiments which have been performed to identify the glutamate‐responsive molecules, i.e. the ionotropic and metabotropic glutamate receptors as well as the glutamate transporters. We also discuss a transgenic mouse model that permits detailed and specific investigations of the role of glial glutamate receptors.
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“This process can be adjusted on demand either through modulation of neurovascular coupling15–17 or via neuronal signaling to astrocytes18.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [17]
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Metadata
- Authors
- Verkhratsky, A., & Kirchhoff, F.
- Affiliations
- University of Manchester (GB)
- Max Planck Society (DE)
- Venue
- Journal of Anatomy
- Publisher
- Wiley
- Published
- 2007-05-15
- Volume
- 210
- Issue
- 6
- Pages
- 651-660
- ISSN
- 0021-8782 (ISSN-L)
- 1469-7580
- PMC
- PMC2375757
- OpenAlex
- W2050984501
- Semantic Scholar
- e1c37e40facf7bda28434bf975bf96308daffcdd
- Cited by
- 156
- References
- 103
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 12 · 2012: 11
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Anatomy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- glutamate, astrocytes, oligodendrocytes, microglia, ionotropic glutamate receptors, metabotropic glutamate receptors, glutamate transporters, transgenic mouse model
- MeSH terms
- Animals, Brain, Glutamates, Humans, Mice, Transgenic, Neuroglia, Neurons, Receptors, Glutamate, Models, Animal, Amino Acid Transport System X-AG, Mice
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