The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Glutamate‐mediated neuronal–glial transmission
Open accessAbstract
The brain is the most complex organ of the human body. It is composed of several highly specialized and heterogeneous populations of cells, represented by neurones (e.g. motoneurons, projection neurons or interneurons), and glia represented by astrocytes, oligodendrocytes and microglia. In recent years there have been numerous studies demonstrating close bidirectional communication of neurons and glia at structural and functional levels. In particular, the excitatory transmitter glutamate has been shown to evoke a variety of responses in astrocytes and oligodendrocytes in the healthy as well as the diseased brain. Here we overview the multitude of glutamate sensing molecules expressed in glia and describe some general experiments which have been performed to identify the glutamate‐responsive molecules, i.e. the ionotropic and metabotropic glutamate receptors as well as the glutamate transporters. We also discuss a transgenic mouse model that permits detailed and specific investigations of the role of glial glutamate receptors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This process can be adjusted on demand either through modulation of neurovascular coupling15–17 or via neuronal signaling to astrocytes18.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [17]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,056
Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,655
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,837
Glia: listening and talking to the synapse
Haydon, P. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058528 · Cited by 1,454
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G. (2002) · Nature Neuroscience · doi:10.1038/nn980 · Cited by 1,446
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334 · cited 1×
“Glial cells perform a multitude of functions, which to a large extent control neuronal development, appearance, maintenance and plasticity of synaptic contacts, energy support, and integration into neuron– glia vascular units (Alvarez-Buylla et al. 2001; Malatesta et al. 2003; Nedergaard et al. 2003; Newman, 2003; Zon…”
BackgroundSubregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81826-7 · Cited by 1,280
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B. L., Pozzan, T., & Volterra, A. (1998) · Nature · doi:10.1038/34651 · Cited by 1,143
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062
A unified hypothesis on the lineage of neural stem cells
Álvarez-Buylla, A., García‐Verdugo, J. M., & Tramontin, A. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067582 · Cited by 1,018
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
Mulligan, S. J., & MacVicar, B. A. (2004) · Nature · doi:10.1038/nature02827 · Cited by 872
Neuronal activity triggers calcium waves in hippocampal astrocyte networks
Dani, J. W., Chernjavsky, A., & Smith, S. J. (1992) · Neuron · doi:10.1016/0896-6273(92)90271-e · Cited by 823
Ionotropic and metabotropic glutamate receptor structure and pharmacology
Kew, J. N. C., & Kemp, J. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2200-z · Cited by 792
Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning
Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K. M. M., Köster, H. J., Borchardt, T., Worley, P., et al. (1999) · Science · doi:10.1126/science.284.5421.1805 · Cited by 791
Neuron-glia metabolic coupling and plasticity
Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 781
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773
Malatesta, P., Hack, M. A., Hartfuss, E., Kettenmann, H., Klinkert, W. E. F., Kirchhoff, F., & Götz, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00116-8 · Cited by 771
Self-citationPhysiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2004) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 718
Self-citationMetabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity
Nakanishi, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90043-4 · Cited by 716
Glial Calcium: Homeostasis and Signaling Function
Verkhratsky, A., Orkand, R. K., & Kettenmann, H. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.99 · Cited by 702
Self-citationMetabotropic glutamate receptors
Ferraguti, F., & Shigemoto, R. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0266-5 · Cited by 682
Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate
Bezzi, P., Gundersen, V., Galbete, J. L., Seifert, G., Steinhäuser, C., Pilati, E., & Volterra, A. (2004) · Nature Neuroscience · doi:10.1038/nn1246 · Cited by 671
Structure and function of the NMDA receptor channel
Mori, H., & Mishina, M. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00109-j · Cited by 658
New roles for astrocytes: Regulation of synaptic transmission
Newman, E. A. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00237-6 · Cited by 619
Petralia, R. S., Wang, Y.-X., Niedzielski, A. S., & Wenthold, R. J. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00533-1 · Cited by 580
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
Salter, M. G., & Fern, R. F. (2005) · Nature · doi:10.1038/nature04301 · Cited by 556
Calcium signalling in glial cells
Verkhratsky, A., & Kettenmann, H. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10048-5 · Cited by 527
Self-citationVerkhratsky, A., & Steinhäuser, C. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00093-4 · Cited by 508
Self-citationNMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
Micu, I., Jiang, Q., Coderre, E., Ridsdale, A., Zhang, L., Woulfe, J., Yin, X., Trapp, B. D., McRory, J. E., Rehak, R., et al. (2005) · Nature · doi:10.1038/nature04474 · Cited by 504
Memories of NMDA receptors and LTP
Collingridge, G. L., & Bliss, T. V. P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80016-u · Cited by 498
Matthias, K., Kirchhoff, F., Seifert, G., Hüttmann, K., Matyash, M., Kettenmann, H., & Steinhäuser, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01750.2003 · Cited by 436
Self-citationCalcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells
Burnashev, N., Khodorova, A. B., Jónás, P., Helm, P. J., Wisden, W., Monyer, H., Seeburg, P. H., & Sakmann, B. J. (1992) · Science · doi:10.1126/science.1317970 · Cited by 430
Structure and Function of Glutamate Receptor Ion Channels
Mayer, M. L., & Armstrong, N. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.050802.084104 · Cited by 415
Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398
Roles and rules of kainate receptors in synaptic transmission
Lerma, J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1118 · Cited by 391
Mallon, B. S., Shick, H. E., Kidd, G. J., & Macklin, W. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00876.2002 · Cited by 382
Live Astrocytes Visualized by Green Fluorescent Protein in Transgenic Mice
Zhuo, L., Sun, B., Zhang, C.-L., Fine, A., Chiu, S. Y., & Messing, A. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8601 · Cited by 364
Excitatory amino acids directly depolarize rat brain astrocytes in primary culture
Bowman, C. L., & Kimelberg, H. K. (1984) · Nature · doi:10.1038/311656a0 · Cited by 357
NMDA Receptors Mediate Neuron-to-Glia Signaling in Mouse Cortical Astrocytes
Lalo, U., Pankratov, Y. V., Kirchhoff, F., North, R. A., & Verkhratsky, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4689-05.2006 · Cited by 355
Self-citationTamaru, Y., Nomura, S., Mizuno, N., & Shigemoto, R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00305-0 · Cited by 345
Müller, T. H., Möller, T., Berger, T., Schnitzer, J., & Kettenmann, H. (1992) · Science · doi:10.1126/science.1317969 · Cited by 340
Mammalian ionotropic glutamate receptors
Wisden, W., & Seeburg, P. H. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90120-n · Cited by 326
AMPA–Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia
Noda, M., Nakanishi, H., Nabekura, J., & Akaike, N. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00251.2000 · Cited by 324
Kainate receptors and synaptic transmission
Huettner, J. E. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00122-9 · Cited by 306
Astroglial processes show spontaneous motility at active synaptic terminals in situ
Hirrlinger, J., Hülsmann, S., & Kirchhoff, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03689.x · Cited by 301
Self-citationInducible site‐specific recombination in myelinating cells
Doerflinger, N., Macklin, W. B., & Popko, B. (2002) · genesis · doi:10.1002/gene.10154 · Cited by 300
Aronica, E., van Vliet, E. A., Mayboroda, O. A., Troost, D., Lopes, F. H. D. S., & Gorter, J. A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00131.x · Cited by 297
Leone, D. P., Genoud, S., Atanasoski, S., Grausenburger, R., Berger, P., METZGER, D., Macklin, W. B., Chambon, P., & Suter, U. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00029-0 · Cited by 275
Glial calcium signaling and neuron–glia communication
Perea, G., & Araque, A. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.015 · Cited by 272
Chemical Excitation of Spinal Neurones
Curtis, D. R., Phillis, J. W., & Watkins, J. C. (1959) · Nature · doi:10.1038/183611a0 · Cited by 272
Seeburg, P. H., Higuchi, M., & Sprengel, R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00062-3 · Cited by 270
Cornell-Bell, A. H., & Finkbeiner, S. M. (1991) · Cell Calcium · doi:10.1016/0143-4160(91)90020-f · Cited by 262
Aoki, C. J., Venkatesan, C., Go, C. G., Mong, J., & Dawson, T. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05202.1994 · Cited by 255
Fusion-related Release of Glutamate from Astrocytes
Zhang, Q., Pangršič, T., Kreft, M., Kržan, M., Li, N., Sul, J., Halassa, M. M., Bockstaele, E. V., Zorec, R., & Haydon, P. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312845200 · Cited by 246
Glutamate receptors in glia: new cells, new inputs and new functions
Gallo, V., & Ghiani, C. A. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01494-2 · Cited by 244
Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes.
Glaum, S. R., Holzwarth, J. A., & Miller, R. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3454 · Cited by 244
EFFECTS OF SODIUM GLUTAMATE ON THE NERVOUS SYSTEM
Hayashi, T. (1954) · The Keio Journal of Medicine · doi:10.2302/kjm.3.183 · Cited by 241
Astrocyte-mediated activation of neuronal kainate receptors
Liu, Q.-S., Xu, Q., Arcuino, G., Kang, J., & Nedergaard, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306731101 · Cited by 230
Ueber einige neuere Forschungen im Gebiete der Anatomie des Centralnervensystems1)
Waldeyer, W. (1891) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0029-1206824 · Cited by 210
Aspartate, glutamate and γ-aminobutyric acid depolarize cultured astrocytes
Kettenmann, H., Backus, K. H., & Schachner, M. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90345-8 · Cited by 210
Synaptotagmin IV regulates glial glutamate release
Zhang, Q., Fukuda, M., Bockstaele, E. V., Pascual, O., & Haydon, P. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401960101 · Cited by 209
Porter, J. T., & McCarthy, K. D. (1995) · Glia · doi:10.1002/glia.440130204 · Cited by 207
Astrocytes of the mouse neocortex express functional N‐methyl‐D‐aspartate receptors
Schipke, C. G., Ohlemeyer, C., Matyash, M., Nolte, C., Kettenmann, H., & Kirchhoff, F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0439fje · Cited by 202
Self-citationHirrlinger, P. G., Scheller, A., Braun, C., Hirrlinger, J., & Kirchhoff, F. (2006) · Glia · doi:10.1002/glia.20342 · Cited by 200
Self-citationRole of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress
Deng, W., Wang, H., Rosenberg, P. A., Volpe, J. J., & Jensen, F. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307850101 · Cited by 179
Yuan, X. Q., Chittajallu, R., Belachew, S. M., Anderson, S. M., McBain, C. J., & Gallo, V. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10368 · Cited by 174
Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice
Hirrlinger, P. G., Scheller, A., Braun, C., Quintela-Schneider, M., Fuss, B., Hirrlinger, J., & Kirchhoff, F. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.08.011 · Cited by 169
Self-citationEvans, R. H., Francis, A. A., Hunt, K., Oakes, D. J., & Watkins, J. C. (1979) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1979.tb08706.x · Cited by 153
Anesthetic actions within the spinal cord: contributions to the state of general anesthesia
Collins, J. G., Kendig, J. J., & Mason, P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)98377-b · Cited by 147
Gottlieb, M., & Matute, C. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199703000-00006 · Cited by 147
Expression of NR1 and NR2A/B subunits of the NMDA receptor in cortical astrocytes
Conti, F., Debiasi, S., Minelli, A., & Melone, M. (1996) · Glia · doi:10.1002/(sici)1098-1136(199607)17:3 · Cited by 143
Jabs, R., Kirchhoff, F., Kettenmann, H., & Steinh�user, C. (1994) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374787 · Cited by 132
Self-citationEntwurf zu einer physiologischen Erklärung der psychischen Erscheinungen
Exner, S. (1894) · Cited by 126
Dermietzel, R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00031-3 · Cited by 117
Krebs, C., Fernandes, H. B., Sheldon, C. A., Raymond, L. A., & Baimbridge, K. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03364.2003 · Cited by 112
Conti, F. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.2.110 · Cited by 111
Ionotropic glutamate receptors in astrocytes
Seifert, G., & Steinhäuser, C. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)32083-6 · Cited by 105
Physiological characteristics of NG2-expressing glial cells
Lin, S.-C., & Bergles, D. (2002) · Journal of Neurocytology · doi:10.1023/a:1025799816285 · Cited by 96
Žiak, D., Chvátal, A., & Syková, E. (1998) · PubMed · Cited by 94
NMDA-activated currents in Bergmann glial cells
Müller, T. H., Grosche, J., Ohlemeyer, C., & Kettenmann, H. (1993) · Neuroreport · doi:10.1097/00001756-199306000-00017 · Cited by 93
Activation of Kainate Receptors Sensitizes Oligodendrocytes to Complement Attack
Alberdi, E. M., Sánchez‐Gómez, M. V., Torre, I., Domercq, M., Pérez‐Samartín, A., Pérez‐Cerdá, F., & Matute, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3780-05.2006 · Cited by 93
NMDA Receptors, Glial Cells, and Clinical Medicine
Lipton, S. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.026 · Cited by 92
Enkvist, M. O. K., Holopainen, I. E., & Åkerman, K. E. O. (1989) · Glia · doi:10.1002/glia.440020602 · Cited by 92
Neuronal and glial localization of NMDA receptors in the cerebral cortex
Conti, F., Minelli, A., Debiasi, S., & Melone, M. (1997) · Molecular Neurobiology · doi:10.1007/bf02740618 · Cited by 90
García-Barcina, J. M., & Matute, C. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01201.x · Cited by 81
Alberdi, E. M., Sánchez‐Gómez, M. V., & Matute, C. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.020 · Cited by 77
Kirischuk, S., Kirchhoff, F., Matyash, V., Kettenmann, H., & Verkhratsky, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00067-6 · Cited by 71
Self-citationCalcium ions and integration in neural circuits
Verkhratsky, A. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01566.x · Cited by 57
Self-citationDepolarization of cultured oligodendrocytes by glutamate and GABA
Kettenmann, H., Gilbert, P., & Schachner, M. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90525-1 · Cited by 56
Select ionotropic glutamate AMPA/kainate receptors are expressed at the astrocyte–vessel interface
Brand‐Schieber, E., Lowery, S. L., & Werner, P. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.051 · Cited by 49
Structure and Function of the NMDA Receptor
Yuan, H., Geballe, M. T., Hansen, K. B., & Traynelis, S. F. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_11 · Cited by 47
Patching the glia reveals the functional organisation of the brain
Verkhratsky, A. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0099-9 · Cited by 45
Self-citationExpression and Functional Analysis of Glutamate Receptors in Glial Cells
Condorelli, D. F., Conti, F., Gallo, V., Kirchhoff, F., Seifert, G., Steinhäuser, C., Verkhratsky, A., & Yuan, X. Q. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4685-6_5 · Cited by 44
Self-citationWaldeyer, W. (1891) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0029-1206855 · Cited by 33
When astrocytes signal, kainate receptors respond
Frerking, M. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400474101 · Cited by 26
Astrocyte Neurotransmitter Uptake
Swanson, R. A. (2004) · Neuroglia · doi:10.1093/acprof:oso/9780195152227.003.0027 · Cited by 23
Nolte (2001) · doi:10.1002/1098-1136(20010101)33:1
Self-citation
Research works printed but not linked: 3
- Exner S, 1894, Entwurf zur physiologischen Erklärung der Psychischen Erscheinungen
- 10.1242/jeb.02208 · DOI
- Swanson RA, 2005, Neuroglia, 346
Cited by
Sorted by citations
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 610
“…of neurotransmitters, astrocytes rapidly remove the K+ [1_TD$DIFF] accumulated as a result of neuronal activity, take up the glutamate released during neurotransmission, and convert the glutamate to glutamine and release it back into presynaptic terminals (Verkhratsky and Kirchhoff, 2007).”
BackgroundMorales, I., Guzmán-MartÃnez, L., Cerda-Troncoso, C., FarÃas, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490
“This process of eliminating extracellular glutamate by astrocytes, it is extremely critical to prevent excitotoxicity (Verkhratsky and Kirchhoff, 2007).”
BackgroundAstrocytes in Alzheimer's Disease
Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 470
“They are particularly important for homeostasis and turnover of the main excitatory neurotransmitter glutamate being the main sink of glutamate in the brain; from the bulk of glutamate released during synaptic transmission, approximately 20% is accumulated into neurons, whereas the remaining 80% is taken up by perisyn…”
BackgroundSelf-citationNeurobiological after-effects of non-invasive brain stimulation
Cirillo, G., Di Pino, G., Capone, F., Ranieri, F., Florio, L., Todisco, V., Tedeschi, G., Funke, K., & Di Lazzaro, V. (2017) · Brain Stimulation · doi:10.1016/j.brs.2016.11.009 · Cited by 446
Astroglia in dementia and Alzheimer's disease
Rodriguez, J. J., Olabarria, M., Chvátal, A., & Verkhratsky, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.172 · Cited by 409
Self-citation
Metadata
- Authors
- Verkhratsky, A., & Kirchhoff, F.
- Affiliations
- University of Manchester (GB)
- Max Planck Society (DE)
- Venue
- Journal of Anatomy
- Publisher
- Wiley
- Published
- 2007-05-15
- Volume
- 210
- Issue
- 6
- Pages
- 651-660
- ISSN
- 0021-8782 (ISSN-L)
- 1469-7580
- PMC
- PMC2375757
- OpenAlex
- W2050984501
- Semantic Scholar
- e1c37e40facf7bda28434bf975bf96308daffcdd
- Cited by
- 156
- References
- 103
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 12 · 2012: 11
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Anatomy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- glutamate, astrocytes, oligodendrocytes, microglia, ionotropic glutamate receptors, metabotropic glutamate receptors, glutamate transporters, transgenic mouse model
- MeSH terms
- Animals, Brain, Glutamates, Humans, Mice, Transgenic, Neuroglia, Neurons, Receptors, Glutamate, Models, Animal, Amino Acid Transport System X-AG, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
