The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Glutamate‐mediated neuronal–glial transmission
Open accessAbstract
The brain is the most complex organ of the human body. It is composed of several highly specialized and heterogeneous populations of cells, represented by neurones (e.g. motoneurons, projection neurons or interneurons), and glia represented by astrocytes, oligodendrocytes and microglia. In recent years there have been numerous studies demonstrating close bidirectional communication of neurons and glia at structural and functional levels. In particular, the excitatory transmitter glutamate has been shown to evoke a variety of responses in astrocytes and oligodendrocytes in the healthy as well as the diseased brain. Here we overview the multitude of glutamate sensing molecules expressed in glia and describe some general experiments which have been performed to identify the glutamate‐responsive molecules, i.e. the ionotropic and metabotropic glutamate receptors as well as the glutamate transporters. We also discuss a transgenic mouse model that permits detailed and specific investigations of the role of glial glutamate receptors.
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“This process can be adjusted on demand either through modulation of neurovascular coupling15–17 or via neuronal signaling to astrocytes18.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [17]
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Cites
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Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 610
“…of neurotransmitters, astrocytes rapidly remove the K+ [1_TD$DIFF] accumulated as a result of neuronal activity, take up the glutamate released during neurotransmission, and convert the glutamate to glutamine and release it back into presynaptic terminals (Verkhratsky and Kirchhoff, 2007).”
BackgroundMorales, I., Guzmán-MartÃnez, L., Cerda-Troncoso, C., FarÃas, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490
“This process of eliminating extracellular glutamate by astrocytes, it is extremely critical to prevent excitotoxicity (Verkhratsky and Kirchhoff, 2007).”
BackgroundAstrocytes in Alzheimer's Disease
Verkhratsky, A., Olabarria, M., Noristani, H. N., Yeh, C., & Rodriguez, J. J. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.017 · Cited by 470
“They are particularly important for homeostasis and turnover of the main excitatory neurotransmitter glutamate being the main sink of glutamate in the brain; from the bulk of glutamate released during synaptic transmission, approximately 20% is accumulated into neurons, whereas the remaining 80% is taken up by perisyn…”
BackgroundSelf-citationNeurobiological after-effects of non-invasive brain stimulation
Cirillo, G., Di Pino, G., Capone, F., Ranieri, F., Florio, L., Todisco, V., Tedeschi, G., Funke, K., & Di Lazzaro, V. (2017) · Brain Stimulation · doi:10.1016/j.brs.2016.11.009 · Cited by 446
Astroglia in dementia and Alzheimer's disease
Rodriguez, J. J., Olabarria, M., Chvátal, A., & Verkhratsky, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.172 · Cited by 409
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Metadata
- Authors
- Verkhratsky, A., & Kirchhoff, F.
- Affiliations
- University of Manchester (GB)
- Max Planck Society (DE)
- Venue
- Journal of Anatomy
- Publisher
- Wiley
- Published
- 2007-05-15
- Volume
- 210
- Issue
- 6
- Pages
- 651-660
- ISSN
- 0021-8782 (ISSN-L)
- 1469-7580
- PMC
- PMC2375757
- OpenAlex
- W2050984501
- Semantic Scholar
- e1c37e40facf7bda28434bf975bf96308daffcdd
- Cited by
- 156
- References
- 103
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 12 · 2012: 11
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Anatomy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Wellcome Trust
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- glutamate, astrocytes, oligodendrocytes, microglia, ionotropic glutamate receptors, metabotropic glutamate receptors, glutamate transporters, transgenic mouse model
- MeSH terms
- Animals, Brain, Glutamates, Humans, Mice, Transgenic, Neuroglia, Neurons, Receptors, Glutamate, Models, Animal, Amino Acid Transport System X-AG, Mice
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