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Cited by 128Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersChild Nutrition and Feeding Issues

Neuropsychiatric Assessmenit of Children with Autism: A Population‐Based Study

Steffenburg, Suzanne·1991·Developmental Medicine & Child Neurology
DOI 10.1111/j.1469-8749.1991.tb14915.x
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Abstract

SUMMARY: Thirty‐five children with autistic disorder and 17 with autistic‐like conditions underwent an exhaustive neurobiological evaluation, and the findings were contrasted with those obtained from various comparison groups. Almost 90 per cent of the children with autistic disorder and autistic‐like conditions had major indications of brain damage or dysfunction. Some of those who did not show such abnormalities had a first‐degree relative with Asperger syndrome. The rate of abnormality was similar to that of severely mentally retarded children, but in excess of that of normal children. Within the autism group, abnormality rate did not correlate with degree of mental retardation. It is concluded that autism has multiple biological aetiologies and that autistic symptoms in a child should always prompt a thorough medical/neurobiological evaluation. RÉSUMÉ: Evaluation neuro‐psychiatrique systématique dans I'autisme: étude de populations Une évaluation neurobiologique exhaustive a été conduite chez 35 enfants atteints d'autisme et 17 avec un état comparable à I'autisme; les résultats furent confrontés à ceux obtenus dans des groupes de comparaison variés. Presque 90 pour cent des énfants avec troubles autistiques et des états comparables à I'autisme présentaient des signes de lésion ou de dysfonction cérébrale. Quelques‐uns des enfants qui ne présentaient pas de telles anomalies avaient un proche au premier degré présentant un syndrome d'Asperger. Le taux d'anomalies était comparable à celui d'enfants arriérés mentaux, et supérieur à celui d'enfants normaux. Dans le groupe d'autisme, le taux d'anomalies n'etait pas corrélé avec le degré de retard mental. Les auteurs concluent que I'autisme a de multiples étiologies biologiques et que I'exisence de symptǒmes autistiques chez un enfant doit toujours conduire rapidement à une évaluation médicale et neurobiologique étendue. ZUSAMMENFFASSUNG: Genaue neuropsychiatrische Untersuchung bei Autismus: Eine populationsbezogene Studie 35 Kinder mit einer autistischen Erkrankung und 17 mit autistischen Symptomen wurden einer eingehenden neurobiologischen Untersuchung unterzogen, und die Ergebnisse wurden denen verschiedener Vergliechsgruppen gegenübergestellt. Fast 90 Prozent der Kinder mit autistischen Erkrankungen und autistischen Symptomen hatten deutliche Hinweise für einen Hirnschaden oder eine Dysfunktion. Einige von denen, die solche Anomalien nicht hatten, hatten einen Verwandten ersten Grades mit Asperger Syndrom. Die Anomalierate entsprach der von geistig schwer behinderten Kindern und überstieg die von gesunden Kindern. Innerhalb der Autismus Gruppe korrelierte die Anomalierate nicht mit dem Grad der geistigen Behinderung. Man kommt zu der Schlußfolgerung, daB der Autismus vielschichtige biologische Atiologien hat, und daß autistische Symptome bei einem Kind sofort gewissenhafte medizinischheurobiologische Untersuchungun erfordern. RESUMEN: Evaluación neuropsiquiátrica amplia en el autismo. Estudio basado en la población Treinta y cinco niños con alteración autística y 17 con alteraciones de tipo autístico fueron objeto de una evaluación neurobiológica exaustiva y los hallazgos fueron contrastado con los obtenidos en diversos grupos comparativos. Casi el 90 por ciento de los niños con alteración autistica o de tipo autístico tenian indicíos de una lesión cerebral o una disfunción cerebral. Algunos de los que no presentaban estas anomalías tenian una semejanza de primer grado con el sindrome de Asperger. La frecuencia de anormalidad era similar a la de niños con un grave retraso mental pero excedia la de los niños normales. Dentro del grupo autista la frecuencia de anormalidad no se relacionaba con el grado de retraso mental. Se concluye que el autismo tiene múltiples etiologías biológicas y los síntomas autísticos en un niño deben obligar siempre a una inmediata evaluación médico‐neurobiologica.

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Authors
Steffenburg, S.
Affiliations
University of Gothenburg (SE)
Corresponding author
Steffenburg, Suzanne
Venue
Developmental Medicine & Child Neurology
Publisher
Wiley
Published
1991-06
Volume
33
Issue
6
Pages
495-511
ISSN
  • 0012-1622 (ISSN-L)
  • 1469-8749
DOI
10.1111/j.1469-8749.1991.tb14915.x
OpenAlex
W2038896774
Cited by
128
References
38
Citations by year
2024: 2 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
4.45
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6374 d)
Locations
  • Developmental Medicine & Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
autism spectrum disorder, neuropsychiatric assessment, brain damage, brain dysfunction, Asperger syndrome, first-degree relatives, intellectual disability, children, comparison groups, population-based study
MeSH terms
Adolescent, Autistic Disorder, Child, Child, Preschool, Chromosome Aberrations, Electroencephalography, Female, Humans, Infant, Intelligence Tests, Male, Mass Screening, Intellectual Disability, Population Surveillance, Social Class, Statistics as Topic, Sweden, Vision, Ocular, Evoked Potentials, Auditory, Brain Stem, Chromosome Disorders

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