Siblings and parents of children with autism: a controlled population-based study
Abstract
SUMMARY: The siblings and parents of 35 children with infantile autism/autistic disorder were compared with those of children with deficits in attention, motor control and perception (DAMP) and of normal children for reported speech and language problems, reading and spelling problems, social deficits and psychiatric disorders. Children with autism tended more often to be the first and only child and there was some support for genetic stoppage in this group. Learning disorders were equally common among siblings and parents of the autism and normal groups, but less common compared with the DAMP group. Asperger syndrome was more common among first‐degree relatives of children with autism compared with normal children. There was a tendency for schizo‐affective disorder to be more common among mothers of children with autism. The findings are discussed in the context of a genetic model for the development of autism. RÉSUMÉ: Fratrie et parents d'enfants avec autisme: une étude de population contrôlée La fratrie et les parents de 35 enfants présentant des troubles de la série autisme infantile/autistique ont été comparés à ceux d'enfants présentant des défauts de l'attention, du contrôle moteur et de la perception (DAMP) et d'enfants normaux, pour les problèmes de parole et de langage, des difficultés de lecture et d'orthographe, des déficits sociaux et des troubles psychiatriques. Les enfants avec autisme étaient fréquemment le premier et seul enfant, et il y a donc une possibilité de contrôle de naissance dans ce groupe. Les troubles d'apprentissage étaient de même fréquence dans la fratrie et la parenté des enfants avec autisme et des contrôles normaux, mais moins fréquents dans le groupe DAMP. Le syndrome d'Asperger était plus fréquent chez les apparentés de premier degré pour les enfants avec autisme que pour les contrôles. II se dessinait une tendance de troubles schizoaffectifs plus fréquents parmi les mères d'enfants avec autisme. Ces données sont discutées dans le contexte d'une modèle génétique de l'apparition de l'autisme. ZUSAMMENFASSUNG: Geschwister und Eltern von Kindern mit Autismus: eine kontrollierte Populationsbezogene Studie Die Geschwister und Eltern von 35 Kindern mit infantilem Autismus/autistischen Störungen wurden mit denen von Kindern mit Dysfunktionen der Aufmerksamkeit, Motorkontrolle und Perzeption (DAMP) und mit denen von normalen Kindern verglichen im Hinblick auf Sprachprobleme, Leseund Rechtschreibschwäche, soziale Probleme und psychiatrische Erkrankungen. Kinder mit Autismus waren häufiger das erste und einzige Kind und es lag bei dieser Gruppe die Vermutung einer genetischen Begrenzung nahe. Lernprobleme waren bei den Geschwistern und Eltern der autischen und der gesunden Kinder gleich häufig, jedoch seltener als in der DAMP Gruppe. Das Asperger Syndrom trat bei Verwandten ersten Grades von Kindern mit Autismus häufiger auf als bei denen der gesunden Kinder. Mütter von Kinder mit Autismus neigten eher zu schizo‐affektiven Erkrankungen. Die Befunde werden im Zusammenhang mit einem genetischen Modell zur Entstehung des Autismus diskutiert. RESUMEN: Hermanos y parientes de niños con autismo: un estudio controlado basado en la población Los hermanos y parientes padres de 35 niños con autismo/alteración autistica se compararon con los de niños con déficits en la atención, control motor y percepción (DAMP) y de niños normales, por lo que refiere a problemas de habla y de lenguaje, problemas de lectura y deletreo, déficits sociales y alteraciones psiquiátricas. Los niños con autismo tienden a ser los primeros hijos o hijos únicos y habia cierto apoyo para una parada genética en el citado grupo. Las alteraciones del aprendizaje eran frecuentes por igual en los hermanos y padres del los niños con autismo y en los normales, peromenos corrientes en comparación con el grupo DAMP. El sindrome de Asperger era más corriente entre los parientes de primer grado en los niños con autismo que en los normales. Había una tendencia hacia la alteración esquizo‐efectiva más frecuente en las madres de los niños con autismo. Se discuten los hallazgos en el contexto de un modelo genético en el desarrollo del autismo.
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The overall prevalence of autism in parents between the Utah survey and the Gillberg et al. study is 2.3%.
“This gives an overall prevalence of autism in parents between the two studies of 2.3%.”
From Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms (2014) · cites this paper as [27]
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- Authors
- Gillberg, C., Gillberg, I. C., & Steffenburg, S.
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 1992-05
- Volume
- 34
- Issue
- 5
- Pages
- 389-398
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W2048781258
- Cited by
- 94
- References
- 29
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, siblings of autistic children, parents of autistic children, Asperger syndrome, learning disabilities, speech and language disorders, reading and spelling difficulties, social dysfunction, mental illness, schizoaffective disorder, first-degree relatives, birth order, maternal mental illness, population-based study
- MeSH terms
- Autistic Disorder, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Risk Factors, Social Environment, Sweden, Incidence, Child of Impaired Parents, Neurocognitive Disorders
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